We are talking to Dr. Ulrich Baumann of Hannover, Germany, about Prof Baumann's experiences both as a junior researcher in Birmingham, UK, investigating the population of cells from which liver regeneration occurs and as a senior clinical caregiver in Hannover using a newly developed inhibitor of enteric bile-salt uptake to treat — with success — a number of the complications that follow liver transplantation in severe ATP8B1 disease (progressive familial intrahepatic cholestasis type 1).