In this episode, Dr. Adriana Garrison walks listeners through the complex world of thrombotic thrombocytopenic purpura (TTP), a life-threatening hematologic emergency. From the earliest laboratory clues to the urgency of clinical recognition, we explore how TTP presents, the key diagnostic tools including the PLASMIC score and ADAMTS13 testing, and the evidence-based treatment strategies that save lives. Dr. Garrison highlights the subtleties of diagnosis, practical tips for differentiating TTP from other thrombotic microangiopathies, and the critical timing of interventions such as plasma exchange and immunotherapy. This episode offers a concise, high-yield guide for clinicians, trainees, and anyone interested in understanding the pathophysiology, diagnosis, and management of TTP. Learn more at bbanys.org