GR Scott Budinger, MD, chief of the Division of Pulmonary and Critical Care Medicine, and Ankit Bharat, MD, chief of Thoracic Surgery, share how the Northwestern Medicine team is handling an influx of and caring for patients with severe COVID-19 illness in the ICU. They discuss when ventilators should be used and alternative approaches the Northwestern Medicine team is utilizing, including extracorporeal membrane oxygenation (ECMO), prone positioning and verticalization therapy, to provide the next level of care when a patient does not respond to ventilation.