In this episode of Beyond the Scale, Dr. Piper Gibson and I take the AIMPrint panel and point it straight at the question everybody actually wants answered: why does the diet that transformed your neighbor do absolutely nothing for you? This is part three of our AIMPrint series, and where part two went gene by gene, this one puts those genes to work.
We start with carb and fat tolerance, because that's where most people get burned. Certain FTO variants may point somebody toward fewer carbs, while a red ACSL5 can make it hard to metabolize fat for energy efficiently, which is how a person can go all in on keto and end up with fatigue, brain fog, and a plan they can't stick to. Then Dr. Gibson opens a real report where the high-carb response sits at 48 percent, the low-carb at 55 percent, and the fat response way down at 33 percent. The read isn't an extreme in either direction. It's moderate carbs around 40 percent, moderate fat around 30 percent, and protein higher. That person had been failing every popular diet because every popular diet pushed them to an extreme their genetics didn't support.
From there we get into fasting, which I've been arguing about with colleagues for years. PPARA in the green suggests a normal ability to shift over to fat for fuel while fasting, but a gene like ACSL5 creates friction in that same system, so the honest answer is that fasting may help and it may need to be built up gradually rather than jumping into a 15 hour window on day one. Age and sex factor in too. Then we hit appetite, where HTR2C, LEP, and LEPR can each dial down fullness independently, and cravings, and finally the exercise response genes, ADRB2 and ADRB3, which shape how fat cells answer the adrenaline signal you send them during a workout. That's part of why some women over 40 can run three miles a day for seven years and still watch the scale climb.
I also share two of my favorite cases: a 26 year old pro hockey player burning thousands of calories a game who could not gain a pound, and one of Dr. Gibson's teenage clients training for a Navy SEAL path whose mom went from overwhelmed to relieved the moment she saw the map instead of the guesswork. Same panel, opposite goals. As always, with faith, our fur babies, and functional health in the mix, this one is about handing you a roadmap so you can stop auditioning diets and start eating for the body you actually have.
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About the Guest:
Dr. Piper Gibson, PhD, is a functional-genetics practitioner whose day-to-day work is with children and the families around them, especially kids navigating tics, Tourette's, ADHD, anxiety, and OCD. She reads a very different set of genes than we do at Body by AIM 360, for very different reasons, which is exactly why these conversations get so good.
What makes her rare is that she can take a page of gene names that look like code words and turn them into something a parent, or a patient, can actually use on a Tuesday. She has been teaching this material for years, she helped shape the thinking behind our AIMPrint panel, and she never once makes your DNA sound like a life sentence.
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Social Handles:
Website: https://regenerating.health
Instagram: https://instagram.com/regeneratinghealth
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Connect with the show and Body by AIM360:
Website: https://bodybyaim360.com
Podcast: https://bodybyaim360.com/podcast
Instagram: https://www.instagram.com/bodybyaim360
Facebook: https://www.facebook.com/bodybyaim360
Book a call: https://calendly.com/bodybyaim360/drtalks
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