Big Biology

Do animals dance to the beat? When is birdsong music for a bird? Humans hear music in everything, but what about other species?

On this episode we talk with Henkjan Honing, professor of music cognition at the University of Amsterdam, about the biology of musicality. Among diverse species, he and his collaborators now study how and why some animals perceive elements of music but others do not.

We also discuss the earliest known examples of human musical instruments and the possible adaptive value of music. All of these topics and more are covered in his recent book, The Evolving Animal Orchestra: In Search of What Makes Us Musical.

Additional sound effects for this episode came from www.zapsplat.com

Cover art: Keating Shahmehri

What rules dictate trade in symbiosis? How did the complex relationship between plants and arbuscular mycorrhizal fungi evolve? What’s really going on in the world beneath our feet?

On this episode, we talk to Toby Kiers, an evolutionary biologist at VU University Amsterdam, about the massive networks of arbuscular mycorrhizal fungi (AMF) that inhabit the soil beneath our feet. Toby studies the symbiotic relationship between AMF and 80-90% of plant species, through which the tube-shaped fungi cells trade nutrients with plant roots in exchange for carbon. We draw connections between these networks and human networks, and discuss whether economists should be taking notes from these systems.

We also talk about SPUN, a non-profit initiative Toby’s group recently launched with the goal of mapping these fungal networks and advocating for their protection worldwide.

Cover art: Keating Shahmehri

Happy Holidays from Big Biology! In our year end wrap-up episode, meet the team behind the podcast and hear our picks for favorite episodes and moments from the last year of the show. We also look forward to what’s in store for 2022. Thanks for your support, and we will see you in the new year!

Music on the episode is from Podington Bear.

How and when did early humans domesticate the plants that we use today? Did these ancient farmers purposefully select traits, or did they domesticate unconsciously? In the future, can breeders and farmers grow more nutritious and robust food using genomics?

In this episode, we talk to Michael Purugganan, an evolutionary biologist at NYU, about some of our favorite foods, where they came from, and what to do to ensure we will still have them in the future.

We also talk about rice, an essential staple crop for the world. Michael describes his genomic work with rice to make it more robust and resilient, especially in the face of climate change and a growing human population. His research is part of a global effort to make a Green Super Rice, a rice variety suitable for the diverse challenges of the future.

Cover art: Keating Shahmehri

Are genes the primary units of selection and main drivers of adaptation? How does a gene’s-eye view of evolution fit into modern biology?

On this episode, we talk with Arvid Ågren, an evolutionary biologist and Wenner-Gren Fellow at Uppsala University, about his new book, “The Gene’s-Eye View of Evolution”. The book chronicles the history of gene-centric views of evolution, which burst onto the scene in 1976 with the publication of Richard Dawkins’s book, "The Selfish Gene". In the gene-centric worldview, genes and alleles take center stage as both key units of selection and drivers of the evolutionary process. Organisms and their phenotypes, by contrast, are viewed as transient vehicles – disposable somas constructed and controlled by genes whose purpose is simply to help those genes replicate.

Previous guests on Big Biology, including Denis Walsh, Denis Noble, Mike Levin and others, have argued strongly for an opposing point of view: that organisms, not genes, should be the focal level for understanding evolution. On this episode, we challenge Arvid to reconcile the gene’s-eye view with our more organism-centered views, and to account for important biological phenomena like the origin of life and adaptation. Our conflicting perspectives led to a stimulating conversation about the nature of evolution, whether the abstractions inherent to the gene’s-eye view are justifiable, and how alternative conceptions of adaptation might lead to unification in biology.

Cover art: Keating Shahmehri

Why is the Serengeti such a special ecosystem? Why does it support so many different species, and what ecological processes regulate the enormous population sizes of its dominant large-bodied herbivores?

On this episode, we talk with Tony Sinclair, professor emeritus of zoology at the University of British Columbia, about his new book “A Place Like No Other: Discovering the Secrets of Serengeti”. Since the 1960s, Tony has studied the bottom-up and top-down processes that regulate wildlife populations in the Serengeti. We talk about how he discovered the major rules of regulation, the unique geography and climate of the Serengeti, the major forces driving wildebeests on epic annual migrations, and the roles that elephants play in stabilizing ecosystems into alternative stable states. We also talk with Tony about the controversial topic of rewilding degraded ecosystems. Tony argues that effective strategies for rewilding emerge only from understanding the fundamental processes that shape ecosystems in the first place.

Cover art: Keating Shahmehri

How do diseases spread from animals to humans? Is it possible to forecast where disease outbreaks will occur and when they will blow up into major health crises? In one of the earliest episodes of Big Biology, Marty and Art talk to Barbara Han, a disease ecologist at the Cary Institute of Ecosystem Studies, about her research on zoonotic disease, how we track the spread of infectious diseases and whether we'll ever be able to predict outbreaks.

What causes Alzheimer’s disease? Why are some people more at risk than others? What are the prospects for a cure and the best options for slowing the onset of symptoms?

On this episode of Big Biology, we talk with Daniel Gibbs, a retired neurologist, about his new book: “A Tattoo on My Brain: A Neurologist’s Personal Battle Against Alzheimer’s Disease”. A few years back, Dan discovered his genetic predisposition to Alzheimer’s disease (AD), which motivated him to chronicle his journey from treating patients with dementia to his own experience with AD. Over 50 million people worldwide are diagnosed with AD, yet we still know surprisingly little about how this disease arises at the cellular and molecular levels, and much less about why such a devastating condition persists in spite of what should be strong natural selection against it.

In the episode, we discuss these enduring mysteries about Alzheimer’s, what it means to be an APOE4 homozygote, and what precautions individuals with AD can take to slow and best manage their symptoms.

Cover art: Keating Shahmehri

What is the free energy principle? How do our brains use active inference to manage uncertainty and stress?

On this episode, we talk with Karl Friston, world-renowned neuroscientist at University College London, about his free energy principle. In order for the human brain or any other self-evidencing system (be it Earthly or alien) to exist, they must be able to make inferences about their environments, and adjust their internal models of the world to resist entropy. In the show, we discuss how Karl’s previous work as a psychiatrist led him to this theory, then take a deep dive into the free energy principle, discussing how it can help us understand stress, agency, DNA, and the possibility of life elsewhere in the universe.

Cover art: Keating Shahmehri

What does the world look like through insect eyes? What biological mechanisms make their vision different from our own? And how might those differences influence their evolution?

On this episode, we talk with UC Irvine evolutionary biologist Adriana Briscoe (@AdrianaBriscoe) about color vision in insects, particularly Heliconius butterflies. We discuss how their perception of the world has led to such massive diversification and how variation in the structure of the light-sensitive opsin proteins that detect light enable species to perceive the world differently. We also discuss how visual perception differences within species might shape behaviors such as pollination, and what ecological factors could drive visual system evolution across the tree of life.

Cover art: Keating Shahmehri