The guys discuss Buffalo’s brutal loss to the Patriots, weighing in on roster construction, game planning and in-game coaching decisions. Also, a Bills-Bucs preview with picks against the spread. Hosted by Ryan O’Leary (@RyanO_Leary) with Bills Wire Managing Editor Nick Wojton (@Nick_Wojton)

The guys dive into this week’s Monday Night Football showdown between the Bills and the Patriots, and give their predictions against the spread and moneyline. Also, thoughts on the Bills’ Thanksgiving night rout of the Saints, Tre White's season-ending knee injury and how the secondary could look moving forward. Hosted by Ryan O’Leary (@RyanO_Leary) with Bills Wire Managing Editor Nick Wojton (@Nick_Wojton)

Host Ryan O’Leary is on his way to Buffalo to take in the Bills-Colts game as a fan, so Bills Wire Managing Editor Nick Wojton offers some advice on how visiting football fans can get the perfect Bills game weekend experience, from places to check out on Saturday night to the best tailgating areas on Sunday. The guys also react to the Bills’ blowout win over the Jets and offer up a Bills-Colts preview with picks against the spread and total.

The guys try to piece together how the Bills actually got beat by the Jaguars and reset their thoughts on the current AFC playoff picture. Could the Bills’ dud in Jacksonville actually cost them the AFC’s No. 1 seed? Also, a Bills-Jets preview with picks against the spread. Hosted by Ryan O’Leary (@RyanO_Leary) with Bills Wire Managing Editor Nick Wojton (@Nick_Wojton)

The guys discuss whether folks should be impressed with Sunday’s grind-it-out win over Miami and look ahead to another double-digit spread against the Jaguars. Also, did the Bills miss an opportunity to trade for Von Miller? Hosted by Ryan O’Leary (@RyanO_Leary) with Bills Wire Managing Editor Nick Wojton (@Nick_Wojton)

The guys discuss the Bills’ standing in what is now a wide-open AFC playoff race. Topics include the NFL trade deadline and a Bills-Dolphins preview with picks against the spread. Hosted by Ryan O’Leary (@RyanO_Leary) with Bills Wire Managing Editor Nick Wojton (@Nick_Wojton)

Steve Borstein fills in for Ryan O'Leary in this week's Bills Wire Podcast, discussing this week's Monday night performance.

The guys look ahead to one of the game’s of the young 2021 season: Bills vs. Chiefs in Kansas City. Are the Bills primed to beat the Chiefs and stake their claim as the best team in the conference? Also, how to approach Dawson Knox in fantasy football leagues and Bills-Chiefs sports betting angles and predictions. Hosted by Ryan O’Leary (@RyanO_Leary) with Bills Wire Managing Editor Nick Wojton (@Nick_Wojton).

The guys discuss Josh Allen’s massive bounce-back performance, Emmanuel Sanders’ instant impact and more on the team’s blowout win over Washington. Also, why the Bills’ defense is for real entering a huge Week 5 showdown in Kansas City. But first things first, the guys give their thoughts on the Bills-Texans matchup and whether they’re backing the Bills as a 16.5-point favorite. Hosted by Ryan O’Leary (@RyanO_Leary) with Bills Wire Managing Editor Nick Wojton (@Nick_Wojton)

The guys discuss the Bills’ Week 2 beatdown of the Dolphins and look ahead to their upcoming matchup with the Washington Football Team. Topics include the team’s hot start on defense and whether Josh Allen is the buy-low candidate of the year in fantasy football after his slow start statistically. The guys also take a look at the Bills-Washington betting lines and make their picks. Hosted by Ryan O’Leary (@RyanO_Leary) with Bills Wire Managing Editor Nick Wojton (@Nick_Wojton)