In which Josh explores the intersection of molecular biology, structural biology, and cardiology with Dr. Andrew Marks. Dr. Marks is the Chairman of the Department of Physiology at Columbia Medical School, the Founding Director of the Wu Center for Molecular Cardiology, and a professor of Physiology and Cellular Biophysics and Medicine. Among other things they discuss his critical development of the rapamycin coated drug eluting stent, his past and current work on Ryanodine receptors, and the multi-system impact of defective Ryanodine receptors.