In which Josh speaks with Stavros Thomopoulos, PhD about biomechanical engineering at the tendon-bone interface. Dr. Thomopoulos is the director of the Caroll Laboratories for Orthopedic Surgery and the Vice Chair for Basic Science Research in Orthopedic Surgery at the Columbia University Irving Medical Center. Among other things, they discuss the challenges of attaching a tendon to a bone and stem cell-based regenerative medicine to improve healing in orthopedic injuries, such as those to the rotator cuff.