This is an interview-style podcast discussing a recently published paper on the characterization of the MapADO enzyme. The conversation is between an interviewer and an expert, covering the enzyme's structure, function, and potential industrial applications in vanillin synthesis

Cultivated meat's future hinges on affordable, sustainable cell culture media. This review details serum-free strategies, including novel ingredients and circular systems, to overcome cost and regulatory challenges. We propose key performance indicators for industry progress.

New research from acib, Graz University of Technology, and myBIOS GmbH systematically compares ethanol- and methanol-inducible promoters in Komagataella phaffii, revealing insights into constitutive expression and identifying PADH2 as a strong candidate for methanol-free protein production.

This podcast explores the current challenges of AI in biomolecular structure prediction, specifically concerning stereochemistry and chiral molecules. We discuss the necessity of human oversight, collaborative strategies, and the significant impact of improved AI accuracy on industrial biotechnology. The episode is based on a publication and work by our spin-off Innophore GmbH.

Discover how a new stepwise gene activation strategy allows cell factories to adapt and achieve significantly higher therapeutic protein production compared to traditional methods. This innovation promises more efficient biomanufacturing and faster development of new medicines.

Researchers have found inexpensive, food-grade alternatives to expensive serum albumins in cell culture media, potentially cutting costs for cultivated meat production and biopharmaceuticals by up to 73%. This breakthrough addresses a major bottleneck, making sustainable protein and affordable medicines more accessible.

A meta-analysis reveals the core genetic blueprint and dynamic gene regulation of CHO cell factories.

This podcast details the engineering of transmembrane alkane monooxygenases (AlkB) to improve Tulipalin A synthesis. The research focuses on enhancing the hydroxylation of isoprenyl acetate, a crucial step for this polymer precursor. Through rational design and site-directed mutagenesis, AlkB variants with significantly improved activity were developed, while maintaining selectivity. The engineered enzyme is part of a novel biocatalytic cascade, representing a significant step towards sustainable production of Tulipalin A and expanding bio-based chemicals.

Dive deep into the complex world of Adeno-Associated Virus (AAV) purification for gene therapy. Our expert guest explains the challenges of separating perfect therapeutic AAVs from a myriad of impurities and discusses the cutting-edge downstream processing techniques—from ultracentrifugation to advanced chromatography—that are making these revolutionary treatments safer, more effective, and accessible.

 Discover how scientists harnessed a unique bacterial lipase, SpL, featuring a novel catalytic tetrad and dual access tunnels, to achieve highly efficient synthesis of pharmaceutical-relevant amides directly in water. This breakthrough bypasses traditional wasteful methods, offering a greener, faster route for chemical manufacturing.