BMJ talk medicine

This month we have an interlude in our rush to ask, acquire, appraise and apply the next quality evidence available to our clinically greedy hands, and spend five minutes going over the process of creating an Archimedes. Dr. Bob Philips, Social Media, and Archimedes Editor take you through what you might expect … what might be asked of you … and how to give the fruits of your intellectual inquiry stand the best chance of hitting print (and this podcast).

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“Do no harm” is a mantra that is drummed into medical students from day 1 of medical school. Most of us have gone into medicine as we believe medicine to be a force of good. However, too much medicine is capable of causing harm to patients and generating unnecessary waste.

In this episode, we spoke about overdiagnosis, communicating risks and benefits with patients, and why you shouldn't take that free lunch sponsored by drug companies.

Recommended reading:

•Preventing overdiagnosis: how to stop harming the healthy. Link: https://www.bmj.com/content/344/bmj.e3502

•Who pays for the pizza? Redefining the relationships between doctors and drug companies. 1: Entanglement. Link: https://www.bmj.com/content/326/7400/1189

Expert guest:

Dr Martin Brunet (@docmartin68 on Twitter) is a GP and a GP trainer at Guildford. He is also the author of The GP Consultation Reimagined: A Tale of Two Houses.

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This podcast is produced and edited by Dom Byrne and Duncan Jarvies.

In this BJSM Podcast Dr Amy Dennett is hosted by Dr Brooke Patterson. Historically people with cancer have been told to rest, and patients and practitioners are often hesitant to get started with physical activity. Amy provides some great practical tips and resources - to support people with cancer exercise safely, safety and precautions, and tips for healthcare services and providers who want to get started with cancer exercise groups. Amy provides a huge array of resources available for healthcare services and clinicians.

Cancer exercise toolkit: https://cancerexercisetoolkit.trekeducation.org/

Cancer exercise toolkit paper: https://cancer.jmir.org/2022/2/e34903/authors

Treatment protocols https://www.eviq.org.au/

International registry and handouts on exercise and cancer https://www.exerciseismedicine.org/eim-in-action/moving-through-cancer/

Patient and clinician resources https://www.petermac.org/cancersurvivorship

Ischaemic stroke is a leading cause of morbidity and mortality.

The World Health Organization defines stroke as “a clinical syndrome consisting of rapidly developing clinical signs of focal (or global) disturbance of cerebral function, lasting more than 24 hours or leading to death, with no apparent cause other than that of vascular origin”.

David Wang, Professor of Neurology, Barrow Neurological Institute, Phoenix, Arizona, gives us a clinical overview of the condition.

For more on ischaemic stroke, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/3000114

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The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

This month we have a feast of studies looking at cardiac arrest. Want to know if one-handed CPR is any good for multi-tasking pre-hospital responders? You'll find out if you listen. Want to know if pre-hospital ECMO should be a thing for elite athletes at major events? We cover that too. Want to know if machine learning is about to revolutionise our practice and solve all our crowding problems? It's all here. And more. Take a listen and keep yourself at the cutting edge!

Read the highlights: https://emj.bmj.com/content/39/5/343

If you enjoy our podcast, please consider leaving us a review or a comment on the EMJ Podcast iTunes page (https://podcasts.apple.com/us/podcast/emj-podcast/id445358244).

Helen Macdonald, The BMJ's research integrity editor is back with another episode, and this week is joined by Joe Ross, professor of medicine and public health at Yale, and US research editor for The BMJ, and Juan Franco, editor in chief of BMJ EBM, and Professor at the Instituto Universitario Hospital Italiano de Buenos Aires

In this episode they discuss;

The US supreme court looks set to overturn Roe v Wade, creating a patchwork of abortion provision across the U.S. We consider the role which evidence might play in documenting how health is affected by that decision, and whether medical evidence is being used at all in the debate.

We'll give you a quick update on treatment for Covid-19

We know that trials are needed for new treatments, but in the face of an exponentially growing amount of observational data, is it time for a shift in that certainty? Joe tells us about his research into whether trials and observational studies of three drugs in covid produce the same answer?

And finally, treatment variation - it's one of the things that helped kick-start the EBM revolution, but there's still much to learn. Juan describes some new research which examines how countries stack up when you compare their handling of and outcomes of a common condition such as a myocardial infarction.

Reading list;

Navigating Loss of Abortion Services — A Large Academic Medical Center Prepares for the Overturn of Roe v. Wade

https://www.nejm.org/doi/full/10.1056/NEJMp2206246.

A living WHO guideline on drugs for covid-19

https://www.bmj.com/content/370/bmj.m3379

Agreement of treatment effects from observational studies and randomized controlled trials evaluating hydroxychloroquine, lopinavir-ritonavir, or dexamethasone for covid-19

https://www.bmj.com/content/377/bmj-2021-069400

Variation in revascularisation use and outcomes of patients in hospital with acute myocardial infarction across six high income countries

https://www.bmj.com/content/377/bmj-2021-069164

In this episode of the IJGC podcast, Editor-in-Chief Dr. Pedro Ramirez is joined by Dr. Susana Banerjee to discuss SOLO1. Dr. Banerjee is a Consultant Medical Oncologist and Research Lead for the Gynaecology Unit. She is also Reader in Women’s Cancers at the Institute of Cancer Research. Dr Banerjee specialises in ovarian cancer and the systemic treatment of endometrial and cervical cancers.

Highlights:

- This report is the longest follow-up period for a PARP inhibitor in the newly diagnosed advanced ovarian cancer.

- The present analysis shows a PFS benefit that is sustained for several years following completion of 2 years of maintenance olaparib.

- PFS benefit was consistent irrespective of higher or lower clinical risk or BRCA1 or BRCA2 mutation.

- SOLO1 is the first to report longer-term follow-up for safety in patients with newly diagnosed ovarian cancer receiving a PARPi as maintenance treatment.

- The safety profile for patients in the maintenance olaparib remained consistent with that reported previously, with no new safety signals. Importantly, no additional cases of MDS or AML were reported.

Editor-in-Chief of the Archives of Disease in Childhood, Dr Nick Brown, and Senior Editor, Dr Rachel Agbeko, bring you the Atoms - the highlights of the June 2022 issue.

Read it on the Archives of Disease in Childhood website: https://adc.bmj.com/content/107/6/i

Please listen to our regular podcasts and subscribe in Apple Podcasts, Google Podcasts, Stitcher and Spotify to get episodes automatically downloaded to your phone and computer. And if you enjoy the podcast, please leave us a review at https://podcasts.apple.com/gb/podcast/adc-podcast/id333278832

The Woven EndoBridge (WEB) device has FDA approval for treatment of wide-necked intracranial bifurcation aneurysms. It has been shown to result in adequate occlusion in bifurcation aneurysms overall, but its usefulness in the individual bifurcation locations has been evaluated separately only in few case series, which were limited by small sample sizes.

In this podcast, JNIS Editor-in-Chief, Dr. Felipe C. Albuquerque, interviews Dr. Nimer Adeeb (1)and Dr. Adam Dmytriw (2) on their paper "Comparing treatment outcomes of various intracranial bifurcation aneurysms locations using the Woven EndoBridge (WEB) device".

Paper available online: https://jnis.bmj.com/content/early/2022/04/27/neurintsurg-2022-018694

Please subscribe to the JNIS Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest episodes. Also, please consider leaving us a review or a comment on the JNIS Podcast iTunes page: https://podcasts.apple.com/gb/podcast/jnis-podcast/id942473767

Thank you for listening!

This episode was edited by Brian O'Toole.

(1) Departments of Neurosurgery and Neurointerventional Surgery, Louisiana State University Health Sciences Center

(2)Neuroendovascular Program, Massachusetts General Hospital, Harvard University

Practical Neurology Editors Phil Smith and Geraint Fuller talk you through the highlights of the June 2022 issue of the journal.

Read more on the PN website: https://pn.bmj.com/content/22/3/175

The full issue here: https://pn.bmj.com/content/22/3

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Thank you for listening.