H. pylori from biology through eradication and salvage, driven by a handful of load-bearing mechanisms. Urease survival explains both diagnosis and why acid suppression causes false negatives, infection location decides gastric versus duodenal disease, and rising clarithromycin resistance has reshaped first-line therapy toward optimized bismuth quadruple and vonoprazan-based regimens.

Topics covered

Key decisions

This is an AI-generated podcast, and some pronunciations may be imperfect. Thank you for your understanding, and we hope you enjoyed this content.

Study the full chapter on Board Pearls, with practice questions, tables and primary-guideline references: Peptic Ulcer Disease and H. pylori

Read this episode: boardpearls.com/gi/episodes/pud-and-h-pylori-ep1

Questions or feedback: [email protected].

• (00:00) - Urease and how the organism survives

Episode two of two on eosinophilic and infectious esophagitis, covering the infections and direct chemical injuries of the esophagus. One principle links them all: the lining got hurt by something that touched it, and immune status, ulcer shape, and biopsy site tell you the agent. Candida, herpes, CMV, pill esophagitis, and caustic ingestion, each read from contact time, anatomy, and host defenses.

Topics covered

Key decisions

This is an AI-generated podcast, and some pronunciations may be imperfect. Thank you for your understanding, and we hope you enjoyed this content.

Study the full chapter on Board Pearls, with practice questions, tables and primary-guideline references: Eosinophilic and Infectious Esophagitis

Read this episode: boardpearls.com/gi/episodes/eosinophilic-and-infectious-esophagitis-ep2

Questions or feedback: [email protected].

• (00:00) - Introduction: the injured lining and its agent

Eosinophilic esophagitis explained from a single mechanism: IL-4 and IL-13 drive eotaxin, eosinophils flood the lining, and chronic inflammation lays down scar. This episode walks the diagnostic criteria, the inflammatory-versus-fibrotic endoscopy split, and the three drugs plus diet, then closes on refractory disease and the dupilumab-plus-dilation combined approach.

Topics covered

Key decisions

This is an AI-generated podcast, and some pronunciations may be imperfect. Thank you for your understanding, and we hope you enjoyed this content.

Study the full chapter on Board Pearls, with practice questions, tables and primary-guideline references: Eosinophilic and Infectious Esophagitis

Read this episode: boardpearls.com/gi/episodes/eosinophilic-and-infectious-esophagitis-ep1

Questions or feedback: [email protected].

• (00:00) - The cytokine engine

Esophageal cancer from histology through staging to treatment, built around the one depth boundary that decides endoscopic versus surgical care. Covers adenocarcinoma versus squamous cell, T-stage depth categories, the mucosa-to-submucosa node-risk jump, the fixed staging workup, and the regimens for locally advanced and metastatic disease.

Topics covered

Key decisions

This is an AI-generated podcast, and some pronunciations may be imperfect. Thank you for your understanding, and we hope you enjoyed this content.

Study the full chapter on Board Pearls, with practice questions, tables and primary-guideline references: Barrett Esophagus and Esophageal Cancer

Read this episode: boardpearls.com/gi/episodes/barrett-and-esophageal-cancer-ep3

Questions or feedback: [email protected].

• (00:00) - Introduction

Endoscopic eradication of Barrett esophagus rests on one principle: the segment holds two kinds of tissue that demand two treatments in a fixed order. Resect visible disease first for a staging specimen, then ablate the flat metaplastic field. This episode covers EMR versus ESD, radiofrequency ablation, cryotherapy salvage, and the intensive post-eradication surveillance that recurrence at the junction and buried glands demands.

Topics covered

Key decisions

This is an AI-generated podcast, and some pronunciations may be imperfect. Thank you for your understanding, and we hope you enjoyed this content.

Study the full chapter on Board Pearls, with practice questions, tables and primary-guideline references: Barrett Esophagus and Esophageal Cancer

Read this episode: boardpearls.com/gi/episodes/barrett-and-esophageal-cancer-ep2

Questions or feedback: [email protected].

• (00:00) - Episode overview: two tissues, two treatments

Episode one of the Barrett Esophagus and Esophageal Cancer chapter covers how to diagnose Barrett's, why the metaplasia climbs toward cancer, and how the dysplasia grade sets the surveillance interval. The organizing idea: the worse the cells look, the faster they progress, and that speed dictates how often you scope. American definition, sampling protocol, screening criteria, and grade-based intervals throughout.

Topics covered

Key decisions

This is an AI-generated podcast, and some pronunciations may be imperfect. Thank you for your understanding, and we hope you enjoyed this content.

Study the full chapter on Board Pearls, with practice questions, tables and primary-guideline references: Barrett Esophagus and Esophageal Cancer

Read this episode: boardpearls.com/gi/episodes/barrett-and-esophageal-cancer-ep1

Questions or feedback: [email protected].

• (00:00) - Introduction and the organizing idea

Drug failure on twice-daily acid suppression is not refractory reflux, it is a reason to work the patient up, and the workup usually turns up something other than reflux. The Lyon Consensus framework, with its acid-exposure cutoffs and symptom-association tests, sorts persistent symptoms into confirmed reflux, borderline, reflux hypersensitivity, and functional heartburn. Antireflux surgery is matched to proven reflux and to motility, and it is reserved for the small group left standing after the mimics are excluded.

Topics covered

Key decisions

This is an AI-generated podcast, and some pronunciations may be imperfect. Thank you for your understanding, and we hope you enjoyed this content.

Study the full chapter on Board Pearls, with practice questions, tables and primary-guideline references: GERD and Refractory Reflux

Read this episode: boardpearls.com/gi/episodes/gerd-and-refractory-reflux-ep3

Questions or feedback: [email protected].

• (00:00) - The patient whose reflux drug has failed

Acid-suppressing drugs work only when their mechanism and timing line up. This episode explains why proton pump inhibitors heal erosive disease when histamine blockers fade, why wrong meal timing is the top cause of apparent PPI failure, and where vonoprazan changes the game.

Topics covered

Key decisions

This is an AI-generated podcast, and some pronunciations may be imperfect. Thank you for your understanding, and we hope you enjoyed this content.

Study the full chapter on Board Pearls, with practice questions, tables and primary-guideline references: GERD and Refractory Reflux

Read this episode: boardpearls.com/gi/episodes/gerd-and-refractory-reflux-ep2

Questions or feedback: [email protected].

• (00:00) - Introduction

GERD is a failure of the antireflux barrier, not acid overproduction. Most patients have a normal resting sphincter, so transient lower esophageal sphincter relaxations are the dominant mechanism, and a sliding hiatal hernia amplifies every failure mode at once. Endoscopy grades the erosive damage, sizes the hernia, and decides treatment intensity, surveillance, and surgical candidacy from one look.

Topics covered

Key decisions

This is an AI-generated podcast, and some pronunciations may be imperfect. Thank you for your understanding, and we hope you enjoyed this content.

Study the full chapter on Board Pearls, with practice questions, tables and primary-guideline references: GERD and Refractory Reflux

Read this episode: boardpearls.com/gi/episodes/gerd-and-refractory-reflux-ep1

Questions or feedback: [email protected].

• (00:00) - Reflux as barrier failure

The fourth and final Esophageal Motility episode covers the weak-body disorders on a normal IRP: ineffective motility, absent contractility, and scleroderma, then the one diagnosis you are required to distrust, outflow obstruction with an elevated IRP but peristalsis still firing. The weak-body tracings resolve into three different diseases depending on two numbers: what the body is doing and what the LES is doing. Obstruction is never a manometry diagnosis alone; it needs pattern, symptoms, and a confirmatory test.

Topics covered

Key decisions

This is an AI-generated podcast, and some pronunciations may be imperfect. Thank you for your understanding, and we hope you enjoyed this content.

Study the full chapter on Board Pearls, with practice questions, tables and primary-guideline references: Esophageal Motility

Read this episode: boardpearls.com/gi/episodes/esophageal-motility-ep4

Questions or feedback: [email protected].

• (00:00) - The weak pump on a normal IRP