Matt has to stop a cold-blooded killer (Charles Bronson) who preys on over-matched opponents (including James Nusser in a role other than Louie Pheeters) (Dabbs Greer makes first credited appearance as 'Jonas').

A dishonest gambler (Vinton Hayworth) uses a mentally challenged man (Strother Martin) in a plot against Matt (Robert Vaughn appears).

An old friend (Leo Gordon) of Matt's is now a gun-for-hire, in town to kill him. This is the actual pilot episode of the television Gunsmoke.

Matt has to figure a way around a six-foot-tall, 200-pound woman with a six-gun.

Doc must find a way to thwart a typhoid epidemic in Dodge (Howard McNear appears).

When an old Indian scout (Eduard Franz) murders a man (DeForest Kelley), Matt pursues him into Comanche territory.

An old rancher (John Dehner) decides that he is going to marry Kitty.

Matt attempts to reform a young troublemaker (including James Nusser in a role other than Louie Pheeters).

A well-liked hardware drummer is actually a man wanted for multiple murders.

An ex-lawman and old friend of Matt's arrives in Dodge with failing eyesight, and a man who wants to kill him.