In this 151st episode, we unpack Brain-Derived Neurotrophic Factor (BDNF) — often called “fertilizer for the brain.” We explore what BDNF is, why it matters for learning, memory, and mood, and how low BDNF shows up in conditions like depression, cognitive decline, and neurodegenerative disease.

Then we dive into evidence-based strategies to naturally support BDNF through exercise, nutrition, sleep, stress management, and targeted supplements, plus emerging data on acupuncture.

Citations:

Electroacupuncture at the Baihui acupoint alleviates cognitive impairment and exerts neuroprotective effects by modulating the expression and processing of brain-derived neurotrophic factor in APP/PS1 transgenic mice

https://pubmed.ncbi.nlm.nih.gov/26739187/

The neuroprotective role of acupuncture and activation of the BDNF signaling pathway

https://pubmed.ncbi.nlm.nih.gov/24566146/

Potential Moderators of Physical Activity on Brain Health

https://pmc.ncbi.nlm.nih.gov/articles/PMC3523571/

Neuroplasticity - exercise-induced response of peripheral brain-derived neurotrophic factor: a systematic review of experimental studies in human subjects

https://pubmed.ncbi.nlm.nih.gov/20726622/

Brain foods: the effects of nutrients on brain function

https://pmc.ncbi.nlm.nih.gov/articles/PMC2805706/

License to run: exercise impacts functional plasticity in the intact and injured central nervous system by using neurotrophins

https://pubmed.ncbi.nlm.nih.gov/16263961/

Effects of curcumin on brain-derived neurotrophic factor levels and oxidative damage in obesity and diabetes

https://pubmed.ncbi.nlm.nih.gov/24476477/