In this high-yield episode, Chris and Mars break down BRCA1 and BRCA2 mutations—essential knowledge for your surgery shelf and Step 2 CK. Learn how these tumor suppressor genes work, the key red flags for suspecting BRCA mutations, and why prophylactic surgery is often the best strategy for ovarian cancer prevention. We’ll also cover high-risk screening protocols, chemoprevention options like Tamoxifen, and critical distinctions between BRCA1 and BRCA2 carriers (including male patients!). Perfect for medical students prepping for their surgery clerkship and exams. Give this a listen before your next clinic!