🔹 What is invasive fungal disease, and who is most at risk for developing invasive fungal disease? (~ 02:46)

🔹 What are the main classes of fungi? (~11:35)

🔹 What are the pros and cons of B-D Glucan and Galactomannan (~19:16)

🔹 How to increase the yield of blood cultures? How to interpret yeast growth in sputum/BAL and urine cultures? (~ 30:42)

🔹 How is invasive fungal disease treated? (~ 35:14)

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📌 Transcript & show notes

Tags: CoreIM, IMCore, Infectious Disease, Hospital Medicine, Hospitalist, ICU, Medical Education, Physician Assistant, Nurse Practitioner, Medical Student, mold

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🔹What are clinically relevant limitations of an A1c vs. a CGM (1:40)

🔹What do the different parts of the ambulatory glucose profile tell you? (09:59)

🔹What are common pitfalls, medications, lifestyle patterns that are important to ask your patient about when seeing them for a visit to manage blood sugar? (15:19)

🔹 How can you titrate insulin based on when you see the hypoglycemia on the ambulatory glucose profile (20:00)

🔹 When there is too much hyperglycemia, how do you titrate insulin when adding on GLP-1 agonists? (26:30)

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📌 Transcript & show notes

Tags: CoreIM, IMCore, Endocrinology, Primary Care, Medical Education, Physician Assistant, Nurse Practitioner, Medical Student, diabetes management, insulin titration

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🔹When is an U/S vs. CT vs. MRI helpful before consulting Interventional Radiology?

🔹What factors go into an IR pre-op evaluation?

🔹 When do drains go in, and when do they come out?

🔹 When a patient has trouble with a drain, what are things you can do before calling IR?

🔹 What does outpatient IR follow up entail, and what does a capping trial of PCN tubes entail?

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Transcript & show notes

Tags: CoreIM, IMCore, Gastroenterology, Primary Care, Medical Education, Physician Assistant, Nurse Practitioner, Medical Student, Medical Imaging, Bleeding Assessment, Drain Management, Procedural Sedation

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🔹 High-yield reversible causes of constipation? (02:26)

🔹 Which type of fiber is more helpful? And is more hydration really better? And bulk-forming laxatives (9:03)

🔹 Osmotic vs Stimulant Laxatives (15:06)

🔹 Suppositories and enemas? (25:39)

🔹Best practices with opioid induced constipation (34:05)

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📌 Transcript and Show Notes

Tags: CoreIM, IMCore, Gastroenterology, GI Pharmacology, Digestive Health, Primary Care, Medical Education, Physician Assistant, Nurse Practitioner, Medical Student, Laxatives, Stool Softeners, Senna, Bisacodyl, Polyethylene Glycol, Bowel Regimen, Magnesium Citrate, Lactulose

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How good are we at preventing HIV? How do efficacy and effectiveness differ? We journey from oral pre-exposure prophylaxis (PrEP) to long-acting injectables, and then to the PURPOSE trials, which look at the use of long-acting lenacapavir as PrEP — a potential game-changer in the field of HIV.

Listen to this latest episode of Beyond Journal Club, a collaboration between CoreIM and NEJM Group, where we put research into context, telling the story of how we arrived at the current standard of care, appreciating the clinical question of the trial at hand, and interpreting what the findings may mean for these patients.

🔹 Sponsor:  NEJM Fellowship Program, click here to learn more and/or apply!

🔹 Transcript and Show Notes

Timestamps:

(02:25) | HIV PrEP Daily Truvada and Descovy

(07:48) | On-Demand Prep

(13:25) | Purpose Trials

(20:56) | Discussion of Effectiveness to Efficacy

Tags:  CoreIM, Internal Medicine, Primary Care, Medical Education, IMCore, Physician Assistant, Nurse Practitioner, Medical Student, HIV Prevention, Infectious Disease

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Our Sponsors:
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What does Lipoprotein(a) tell us that a standard lipid panel doesn’t? Should we be testing everyone for it? Dive into the genetics, clinical implications, and evolving management strategies for Lp(a). Learn how to interpret results, counsel patients, and navigate topics with limited data like aspirin and PCSK9 inhibitors in treatment.

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🔹 Transcript and Show Notes

Timestamps:

(02:17) | Pearl 1: What makes Lp(a) unique? How does it raise ASCVD risk?

(10:32) | Pearl 2: Who should be tested for Lp(a)? When and why?

(16:54) | Pearl 3: Understanding and interpreting Lp(a) levels

(24:04) | Pearl 4: How does an elevated Lp(a) affect management?

(37:05)| Pearl 5: The role of aspirin and PCSK9 inhibitors in Lp(a)

Tags: CoreIM, Internal Medicine, Primary Care, Preventive Cardiology, Atherosclerosis, Lipid Management, Medical Education, IMCore, Physician Assistant, Nurse Practitioner, Medical Student

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A new way to think of clots beyond provoked vs. unprovoked: Learn all about how important it is to think about reversibility! What patient states affect the inherited thrombophilia testing? Learn the nuances and practical approaches!

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Transcript and Show Notes

Timestamps:

(02:07) | Pearl 1: Reframing Provoked vs. Unprovoked to Reversibility

(09:12) | Pearl 2: How can Virchow's Triad help us categorize the etiology of a clot?

(17:01) | Pearl 3: What factors affect anti-thrombin III, Protein C and Protein S deficiency

(28:50) | Pearl 4: Is the Factor V Leiden or Prothrombin Gene Mutation as important as the family history?

(38:41) | Pearl 5: Spaced Repetition of Learning Points

Tags: CoreIM, Internal Medicine, ClinicalPearls, Medical Education, IMCore, hospitalist, physician assistant, nurse practitioner, medical student, internal medicine, hematology

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What is the impact of microplastics on human health? How can we use observational data to support the argument that microplastics may lead to poor health outcomes?

Join us as we tackle these questions and discuss the APAChE study on microplastics and cardiovascular disease on this episode of Beyond Journal Club, a series brought to you by Core IM in collaboration with NEJM Group.

🔹 Transcript and Show Notes

🔹 Behind The Scenes YouTube Video

This episode is also sponsored by Factor! Get fresh, ready-made meals delivered to your door. Use the code factorpodcast for a special discount at factor75.com.

Timestamps:

(02:24) | Introduction to Plastic's Key Players

(07:59) | Bradhill/Observational Work

(10:33) | APAChE Study Deep Dive

(18:03) | Discussion

📢 Special Thanks:

🎙️ Audio Editing: Jerome Reyes

📊 Graphics: Dr. Jimin Hwang

Tags:

CoreIM, Environmental Health, Medical Education, IMCore, Public Health, Clinical Pearls, Physician, Medical Student, Nurse Practitioner, Epidemiology

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What is the last sense to go? How can music create connection, ease anxiety, and help process emotions at the end of life? Join Dr. Jafar Al-Mondhiry, Dr. Harry Han, and music therapist Bryanna Tobin as they explore the power of music therapy in hospice care, sharing moving stories and clinical insights.

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🔹 Transcript and Show Notes

Timestamps:

(00: 39) | 1st: What is Music Therapy in Hospice?

(07:59) | 2nd: A Powerful Story

(14:19) | 3rd: Challenges in the Field of Music Therapy

Tags:  IMCore, CoreIM, primary care, palliative care, end-of-life, oncology nurse practitioner, pharmacist, physician assistant

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Incidental fibrosis on CT —what now? What does prone imaging tell you? Is it fibrosis, aspiration, or atelectasis? And once you diagnose ILD, does the “alphabet soup” really matter for treatment? Antifibrotics vs. immunosuppression?

Plus, how do we bridge the gap when social barriers make care unsafe?

🔹 This episode is also sponsored by Factor! Get fresh, ready-made meals delivered to your door. Use the code factorpodcast for a special discount at factor75.com.

Transcript and Show Notes

Timestamps:

(01:26) | Deep Dive 1

(06:38) | Deep Dive 2

(12:37) | Deep Dive 3

(21:13) | Deep Dive 4

(28:06) | Deep Dive 5

Tags: CoreIM, Internal Medicine, Pulmonology, Clinical Pearls, Medical Education, IMCore, Radiology, Hospitalist, Physician Assistant, Nurse Practitioner, Medical Student, interstitial lung disease

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