Featuring articles on HIV prevention, left atrial appendage closure after ablation for atrial fibrillation, timing of thrombolysis for stroke, congenital diarrhea and enteropathy, and the association between wealth and mortality in the United States and Europe; a review article on malaria; a Clinical Problem-Solving describing a “hot” cardiomyopathy; and Perspectives on physician shadowing, application overload, medical school grading, and impersonal personal statements.

Featuring articles on intensive blood-pressure control in patients with diabetes, IgG4-related disease, severe chronic rhinosinusitis, advanced breast cancer, and vaccinating against C. difficile infection; a review article on chronic cough in adults; a case report of a man with hepatocellular carcinoma; an editorial on order out of chaos; and Perspectives on health care bridges, on partnerships between pharmaceutical and telehealth companies, and on the definition of failure.

Featuring articles on breast cancer, bloodstream infection, subarachnoid hemorrhage, scrub typhus, and birth-related mortality; a review article on the evaluation and treatment of infertility; a case report of a woman with altered mental status and acidemia; and Perspectives on advancing transgender health amid policy threats, on evidence-based work design, and on what an oncologist had wished she had done for a grieving father.

Featuring articles on bacterial vaginosis, diabetes prevention, Danon disease, chronic spontaneous urticaria, and VITT-like monoclonal gammopathy of thrombotic significance; a review article on micronutrients; a Clinical Problem-Solving on unveiling the unforeseen; and Perspectives on bankruptcy and genetic information, on drug development for rare diseases, on facing political attacks on medical education, and on sustaining equity efforts in the face of regression.

Featuring articles on H5N1 infection, chronic subdural hematoma, achondroplasia, and B-cell acute lymphoblastic leukemia; a review article on carceral health care; a case report of a woman with weakness, back pain, and pancytopenia; and Perspectives on the changing approach to addiction, on the moral injury of inhaler prescribing, and on how one size fits … some.

Featuring articles on ventricular tachycardia, chronic lymphocytic leukemia, chronic kidney disease, kidney allografts, and a low-dose yellow fever vaccine; a review article on tubal ectopic pregnancy; a case report of a man with abdominal pain; and Perspectives on reducing the financial toxicity of rapidly approved drugs, on resilience, and on the death of an unlikable man.

Featuring articles on therapies in acute myocardial infarction and in neuroendocrine tumors, mpox in Africa, and T-cell lymphoma after CAR T-cell therapy; a review article on food and nutrition insecurity; a case report of a woman with headache and dysesthesia; and Perspectives on Marburg virus disease in Rwanda, on the rise of private equity in health care, and on medical aid in dying.

Featuring articles on IgA nephropathy, a treatment in children with obesity, NRG1 fusion–positive cancer, a case of a T-cell lymphoma, and the discovery of GLP-1–based drugs; a review article on hemophagocytic lymphohistiocytosis, a Clinical Problem-Solving on traveling companions; and Perspectives on cell and gene therapies, on gender-affirming care, and on the man who lives in the cardboard box.

Featuring articles on heart failure and obesity, oral anticoagulation during TAVI, hemophilia A, hereditary angioedema, and tuberculosis; a review article on sport-related concussion; a case report of a man with syncope, ankle swelling, and abnormal chest imaging; and Perspectives on e-cigarettes at the Supreme Court, on providing interstate telehealth abortion services to patients in restrictive states, on listening to TikTok, and on what is the relative value of a baby.

Featuring articles on esophageal cancer, out-of-hospital cardiac arrest, and atrial fibrillation; a review article on the physiology of hunger; a case report of a man with exertional dyspnea and chest pain; a Medicine and Society on evaluating the inclusion of sex in clinical algorithms; and Perspectives on Ebola, on U.S. generic drug shortages, on gender-affirming surgical care in carceral settings, and on the pediatrician’s lament.