Featuring articles on lipoprotein(a), familial polycythemia, leukocyte adhesion deficiency, COPD, and on policies on reducing alcohol consumption; a review article on addressing alcohol use; a Clinical Problem-Solving on gazing into a crystal ball; and Perspectives on death and taxes, on cancer metastases, and on a good innings.

Featuring articles on bronchiectasis, influenza, clonal hematopoiesis of indeterminate potential, and metachromatic leukodystrophy; a review article on biology of the Fc neonatal receptor; a case report of a woman with sore throat and rash; and Perspectives on HIV preexposure prophylaxis, on fossil fuels, and on Medicaid’s mandate for children and adolescents.

Featuring articles on obinutuzumab in active lupus nephritis, tecovirimat for mpox, treatments for paroxysmal atrial fibrillation, and gene therapy for hemophilia B; a review article on enteral nutrition in hospitalized adults; a case report of a woman with cough and weight loss; and Perspectives on withdrawal of the United States from the WHO, on what’s next for nicotine, on the value zeitgeist, and on doctors in revolution and war.

Featuring articles on cancer-associated venous thromboembolism, endovascular treatment for stroke, dapagliflozin in patients undergoing TAVI, screening for prostate cancer, and extrachromosomal DNA; a review article on otitis media in young children; a case report of a woman with flank pain, fever, and hypoxemia; and Perspectives on some efforts toward equity and on breaking the sacred promise.

Featuring articles on HIV prevention, left atrial appendage closure after ablation for atrial fibrillation, timing of thrombolysis for stroke, congenital diarrhea and enteropathy, and the association between wealth and mortality in the United States and Europe; a review article on malaria; a Clinical Problem-Solving describing a “hot” cardiomyopathy; and Perspectives on physician shadowing, application overload, medical school grading, and impersonal personal statements.

Featuring articles on intensive blood-pressure control in patients with diabetes, IgG4-related disease, severe chronic rhinosinusitis, advanced breast cancer, and vaccinating against C. difficile infection; a review article on chronic cough in adults; a case report of a man with hepatocellular carcinoma; an editorial on order out of chaos; and Perspectives on health care bridges, on partnerships between pharmaceutical and telehealth companies, and on the definition of failure.

Featuring articles on breast cancer, bloodstream infection, subarachnoid hemorrhage, scrub typhus, and birth-related mortality; a review article on the evaluation and treatment of infertility; a case report of a woman with altered mental status and acidemia; and Perspectives on advancing transgender health amid policy threats, on evidence-based work design, and on what an oncologist had wished she had done for a grieving father.

Featuring articles on bacterial vaginosis, diabetes prevention, Danon disease, chronic spontaneous urticaria, and VITT-like monoclonal gammopathy of thrombotic significance; a review article on micronutrients; a Clinical Problem-Solving on unveiling the unforeseen; and Perspectives on bankruptcy and genetic information, on drug development for rare diseases, on facing political attacks on medical education, and on sustaining equity efforts in the face of regression.

Featuring articles on H5N1 infection, chronic subdural hematoma, achondroplasia, and B-cell acute lymphoblastic leukemia; a review article on carceral health care; a case report of a woman with weakness, back pain, and pancytopenia; and Perspectives on the changing approach to addiction, on the moral injury of inhaler prescribing, and on how one size fits … some.

Featuring articles on ventricular tachycardia, chronic lymphocytic leukemia, chronic kidney disease, kidney allografts, and a low-dose yellow fever vaccine; a review article on tubal ectopic pregnancy; a case report of a man with abdominal pain; and Perspectives on reducing the financial toxicity of rapidly approved drugs, on resilience, and on the death of an unlikable man.