NEJM This Week

This week, we feature new research on gene editing for hereditary angioedema, a chemotherapy-free approach to acute lymphoblastic leukemia, and treatments for ulcerative colitis and HIV. We review adult ADHD and follow a challenging case involving a spinal mass. We report on lung cancer screening, and Perspectives explore care interventions for older adults, access to fertility care, and the evolving role of AI in medicine.

This week, we feature new research on transcatheter treatment for tricuspid regurgitation, multicancer early-detection testing, resuscitation strategies for septic shock, and an experimental approach to restoring vision. We review advances in breast cancer treatment, follow a puzzling case of prolonged fever and lymphadenopathy, and report on scientific reproducibility. Perspectives discuss outbreak response, obesity trials, and the enduring value of the medical generalist.

This week, we feature new research on statin therapy in older adults, treatments for IgG4-related disease and advanced breast cancer, and a once-weekly oral regimen for HIV. We review Andes virus and follow a challenging case of a disseminated infection. Articles explore scientific independence, opioid-settlement funds, pharmaceutical policy, and the role of community in patient care.

This week, we feature new research on anticoagulation for atrial fibrillation, treatment for narcolepsy, and gene and cell therapies for multiple myeloma and Wiskott–Aldrich syndrome. We review the clinical use of common genetic variants and follow a case of a young child with fatigue and frequent falls. Perspectives explore access to sickle cell therapies, child health, and biomedical science.

This week, we feature new research on colorectal cancer surveillance, metabolic acidosis in critical illness, pediatric leukemia, and food-allergy prevention. We also review esophageal cancer and follow a case of severe nutritional deficiency and memory loss. Perspectives address AI and the clinical workforce, physician staffing in the Indian Health Service, human trafficking and child health, and the enduring legacy of the HIV epidemic.

This week, we feature new research on gene-edited therapies for children with β-thalassemia and sickle cell disease, treatment for membranous nephropathy, coronary revascularization after myocardial infarction, and an outbreak of severe methemoglobinemia. We review treatment decisions in multiple myeloma, follow a case of man with fever and rash, and report on psychedelic drug development. Perspectives address preventive care, AI-assisted translation, barriers to health care access, and the long shadow of Bedlam.

This week, we feature new research on acute myeloid leukemia, achondroplasia, pediatric septic shock, and RAS-mutant lung cancer. We also review the evaluation and management of pulmonary nodules and follow a diagnostic case of recurrent fractures. Perspectives explore reproductive health care, the human–animal bond in health care access, and on creating space for patients’ voices in clinical decision making.

This week, we feature new research on acute respiratory failure, wheezing in childhood, lung cancer, and obesity. We review myeloproliferative neoplasms and follow a diagnostic case of a patient with myasthenia gravis who developed dyspnea and weakness. Perspectives explore medical marijuana research, AI in clinical care, sexual and gender minority health research, and the Perspectives Editor saying goodbye.

This week, we feature new research on polymyalgia rheumatica, hypercholesterolemia, prostate cancer, and multiple myeloma. We review evidence-based strategies for tobacco cessation, and follow a case of a woman with nausea, dizziness, and metabolic acidosis. We discuss recent advances in gene editing for rare metabolic diseases. Perspectives address HIV care, health care quality, medical ethics, and finding resilience in the face of serious illness.

This week, we feature new research on chronic kidney disease, high-risk prostate cancer, peripheral artery disease, and oxygen therapy after cardiac arrest. We review the evaluation and management of syncope, follow a challenging case of immune-related inflammatory illness, and report on Perspectives exploring pandemic preparedness, the Bundibugyo Ebola outbreak, and physician mental health.