Featuring articles on cancer cachexia, MDR tuberculosis, Ebola virus disease, and severe asthma; a review article on the nonsurgical management of chronic venous insufficiency; a case report of a woman with end-stage liver disease and headache; and Perspectives on providing effective medical care to autistic people, on independent physician associations, on face-to-face learning, and on those who are well known to us.

Featuring articles on PCI before transcatheter aortic-valve implantation, treatments in patients with type 2 diabetes, in leprosy, in refractory adult ALL, and in ATTR cardiomyopathy; a review article on drug reaction with eosinophilia and systemic symptoms; a case report of a boy with recurrent fever; and Perspectives on an autopsy of a drug withdrawal, on clearing dense drug-patent thickets, on how a survey change sheds light on iatrogenic opioid use disorder and on being tethered.

Featuring articles on treatments for atrial fibrillation and stable coronary disease, for chronic hepatitis B, and for metastatic breast cancer; the 30-year cardiovascular disease risk in healthy women; and prenatal screening and detection of maternal cancer; a review article on sepsis and septic shock; a case report of a woman with headache, fever, and respiratory failure; and Perspectives on Medicare’s bundled-payment programs, on handcuffs and unexpected deaths, on the Marburg outbreak in Rwanda, and on the care that saved one parent.

Featuring articles on pembrolizumab perioperative therapy in breast cancer, reduced dose schedules or fractional doses of pneumococcal conjugate vaccine, and nivolumab plus ipilimumab in colorectal cancer; a review article on degenerative rotator-cuff disorders; a case report of a man with seizures and agitation; a Clinical Implications of Basic Research on boning up on boning up; and Perspectives on the Duffy null phenotype; on sickle cell trait, inequity, and the need for change, on “target trial emulation” for observational studies, and on a good day.

Featuring articles on a nationwide couple-based genetic screening; adjunctive embolization for subdural hematoma; a late-liver-stage attenuated malaria vaccine; and climate change, floods, and human health; a review article on Candida auris infections; a case report of a girl with abdominal pain; and Perspectives on Medicare’s first round of drug-price negotiation; on invisible deaths; on minding the sentinel; and on Saint Didacus, fetal death, and dual loyalty.

Featuring articles on perioperative durvalumab in bladder cancer, transcatheter valve repair for mitral regurgitation, chemoradiotherapy in gastric cancer, and lessons from England’s National Health Service; a review article on lung transplantation; a case report of a newborn with hypoxemia and a lung opacity; and Perspectives on our latest brief case studies on efforts toward equity and on forensic nurse examiners.

Featuring articles on an invasive treatment strategy in older patients with myocardial infarction, a randomized trial of very early medication abortion, therapies in stage III melanoma, and on long Covid defined; a review article on uterine fibroids; a Clinical Problem-Solving on two sides to the story; and Perspectives on the U.S. Latino HIV crisis, on reframing cerebral palsy as a lifelong disability, and on an older patient and his physician finding an immediate, resonant connection in a haunting song recalled from long ago and far away.

Featuring articles on semaglutide in persons with obesity and knee osteoarthritis, the addition of PI3K inhibition in breast cancer, treatments in older patients with myeloma, and total hip replacement for hip osteoarthritis; a review article on lead poisoning; a case report of a man with dyspnea after old myocardial infarction; and Perspectives on large language models and the medical record, on measuring AI against the health care we have, on the failing U.S. health system, and on the contemporary rise of pronatalism.

Featuring articles on treatments in heart failure, advanced non–small-cell lung cancer, and Dupuytren’s contracture; a neurodevelopmental disorder caused by deletion in a long noncoding RNA; a review article on burnout and depression among physicians; a case report of a woman with confusion, aphasia, and a brain mass; a Medicine and Society article on how the idea of social contagion shaped trans medicine; and Perspectives on navigating clinicians’ conscience-based refusals, on opportunity costs of Medicare Advantage rebates, on celebrating public health, and on taking our own medicine.

Featuring articles on nivolumab in advanced Hodgkin’s lymphoma, kidney transplantation from donors with HIV, a modular communicative leadless pacing–defibrillator system, stereotactic body radiotherapy in prostate cancer, and on how DNA sensing drives inflammation; a review article on cryoglobulinemia; a case report of a woman with dyspnea, dysphagia, and dysarthria; and a Special Report and Perspectives on the U.S. elections and health policy.