Dominate C. diff! Learn to distinguish colonization from infection, select first-line therapies, and counsel patients on recurrence prevention and microbiome recovery. We’re joined by IDSA past president and expert on foodborne and intestinal infections, Dr. Cindy Sears (Johns Hopkins University) for a comprehensive update on Clostridioides difficile (C. diff, Cdiff, CDAD, CDI).
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Show Segments
00:00 Intro03:00 Guest bio and hobby04:25 Case of Charles Fleur Fontaine06:00 Risk factors and epidemiology08:00 Antibiotic hierarchy of risk10:00 Diagnosis, testing strategies14:00 Defining severity17:30 Treatment options20:00 Microbiome recovery strategies24:00 Probiotics and postbiotics27:00 Infection control counseling30:00 C. diff and colon cancer32:00 Recurrent C. diff strategies35:00 Why some FMT and bezlotoxumab were discontinued38:00 Microbiota replacement therapies43:00 Prophylaxis strategies45:00 Future therapies and ongoing research47:00 Audience Q&A52:00 Outro
Credits
Written and Produced by: Matthew Watto, MD, FACP Cover Art and Infographic by:Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP Reviewer: Sai S Achi MD,MBA,FACPShowrunners: Matthew Watto MD, FACP; Paul Williams MD, FACPTechnical Production: PodPasteGuest: Cynthia Sears MD
Disclosures
Dr. Sears reports no relevant financial disclosures. Dr. Williams financial relationships disclosed include a Merck grant or research support. This relationship has not ended.
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