POTS is a chronic autonomic disorder characterized by excessive orthostatic tachycardia and multisystem symptoms that affects an estimated 0.1% to 1% of the US population. Author Satish Raj, MD, MSCI, of University of Calgary Cumming School of Medicine joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss current evidence about the pathophysiology, diagnosis, and management of POTS. Related Content:

• Postural Orthostatic Tachycardia Syndrome (POTS)

Naltrexone, acamprosate, disulfiram, and topiramate are effective but underused medications for treatment of alcohol use disorder. Author Stephen Holt, MD, MS, of Yale School of Medicine joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss first-line pharmacotherapy for alcohol use disorder and important safety, efficacy, and hospital initiation considerations. Related Content:

• Medications for Alcohol Use Disorder

Circulating tumor DNA (ctDNA)(liquid biopsies) can help monitor cancer progression, detect residual cancer after treatment, and identify genetic changes within cancer cells that could affect treatment response. Author Ben Ho Park, MD, PhD, of the Vanderbilt-Ingram Cancer Center discusses current evidence regarding use of liquid biopsies in management of cancer with JAMA Deputy Editor Mary McGrae McDermott, MD. Related Content:

• Liquid Biopsies for Cancer
• Applications of Liquid Biopsy for Surgical Patients With Cancer

Physical activity is an effective component of care for people with chronic medical conditions. In this podcast, JAMA Insights author Alessio Bricca, PhD, University of Southern Denmark, discusses adaptable methods to promote physical activity in patients with chronic medical conditions with host Anne Rentoumis Cappola, MD, ScM. Related Content:

• Communicating With Patients About Physical Activity

Hodgkin lymphoma is a relatively rare disease, with approximately 82 409 incident cases reported globally in 2022, and 8720 cases reported in the US in 2025. Author Alison Moskowitz, MD, of Memorial Sloan Kettering Cancer Center joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss current evidence about the diagnosis and management of Hodgkin lymphoma in adults. Related Content:

• Classic Hodgkin Lymphoma

Suboptimal sleep quality and quantity are associated with higher body mass index and more difficulty losing weight. In this podcast, JAMA Insights author Atul Malhotra, MD, from the University of California, San Diego, discusses evidence regarding sleep and obesity with JAMA Deputy Editor Mary McDermott, MD. Related Content:

• Sleep Health and Obesity

Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of global mortality and is strongly associated with cumulative exposure to atherogenic lipoproteins across the lifespan. Author Amber E. Johnson, MD, MS, MBA, of the University of Chicago joins JAMA Senior Editor Philip Greenland, MD, to discuss the ACC/AHA guideline on management of dyslipidemia. Related Content:

• Dyslipidemia Evaluation and Management
• Implications of the 2026 Dyslipidemia Guideline for Primary Prevention Statin Therapy

Hip fractures are a leading cause of disability and death in older adults. This episode summarizes risk factors, prevention, and medical and surgical management of hip fractures. JAMA Deputy Editor Mary M. McDermott, MD, interviews Douglas Kiel, MD, MPH, of Harvard Medical School and Marcus Institute for Aging Research. Related Content:

• Hip Fractures

Alcohol-related liver disease is the leading cause of liver-related morbidity and mortality and the most common indication for liver transplant in Europe and the US. Author Aleksander Krag, MD, PhD, of the University of Southern Denmark joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss a recent review on this topic published in JAMA. Related Content:

• Alcohol-Related Liver Disease

Worldwide, heterozygous familial hypercholesterolemia (FH) affects approximately 1 in 250 to 350 individuals. Author James Stein, MD, of the University of Wisconsin School of Medicine and Public Health joins JAMA Deputy Editor Karen Lasser, MD, MPH, to discuss the epidemiology, diagnosis, and treatment of both homozygous and heterozygous FH. Related Content:

• Familial Hypercholesterolemia