Featuring articles on lenacapavir for HIV prevention in cisgender women, tirzepatide for treatment of obstructive sleep apnea, lymphadenectomy for muscle-invasive bladder cancer, secondary T-cell lymphoma after CAR T-cell therapy, and immunity and early colorectal carcinogenesis; a review article on prolonged grief disorder; a Clinical Problem-Solving on avoiding rash decisions; and Perspectives on health care reform and the 2024 U.S. elections, on financial toxicity for patients from the use of AI, on the Supreme Court’s shadowy treatment of public health, and on caring for our communities.

Featuring articles on systematic vs. targeted biopsy for prostate cancer screening, ziresovir in hospitalized infants with RSV, gene therapy for factor IX deficiency, and a phase 2 trial of tulisokibart for ulcerative colitis; a review article on neuroleptic malignant syndrome; a case report of a woman with kidney lesions and lytic bone disease; and Perspectives on Dobbs revisited, on the role of physicians on ethics committees after Dobbs, on accessible weight scales and exam tables, and on ensuring a safe and sufficient global blood supply.

Featuring articles on long-term oxygen therapy in severe hypoxemia, reducing opioid overdose deaths, blocking CSF1R in chronic GVHD, and pomalidomide in hereditary hemorrhagic telangiectasia; a review article on central nervous system vasculitis; a case report of a man with confusion and kidney failure; a Medicine and Society on house staff unionization revisited; and Perspectives on ethical challenges in pragmatic and cluster RCTs, on the sense and sensibility of sensitivity analyses, and on there being no one in charge.

Featuring articles on treatments in newly diagnosed chronic myeloid leukemia and RNA therapeutics in mixed hyperlipidemia; a review article on clinical approaches to firearm injury prevention; a case report of a woman with edema, arthritis, and proteinuria; and Perspectives on keeping SNAP in line with global evidence, on ingesting risk, on centering the peripheral brain, and on how health care burdens patients.

Featuring articles on doxorubicin plus trabectedin in leiomyosarcoma, a monoclonal antibody for migraine prevention, adjunctive argatroban or eptifibatide for ischemic stroke, and a new orthonairovirus associated with febrile illness; a review article on pancreatic cysts; a case report of a man with pain and dyspnea; a Medicine and Society on building a community of medical learning; and Perspectives on supreme power, on shared savings for nursing homes, on moral injury and the global health workforce crisis, and on asking patients if they feel safe at home.

Featuring articles on amino acid infusion and kidney protection, azithromycin to reduce childhood mortality in Niger, belzutifan in renal-cell carcinoma, and a transfusion strategy in traumatic brain injury; a review article on sexual dysfunction in women; a case report of a woman with aphasia, anemia, and a breast mass; and Perspectives on a series of brief cases on efforts toward equity and on controlling global antimicrobial resistance.

Featuring articles on osimertinib in stage III EGFR-mutated lung cancer, cognitive motor dissociation in disorders of consciousness, rapid deployment of a brain–computer interface in ALS, and the longevity of a brain–computer interface for ALS; a review article on the genetics of chronic kidney disease; a case report of a boy with autism and decreased vision; and Perspectives on medical expertise, on collecting data on sexual orientation and gender identity, and on the pursuit of polka dots.

Featuring articles on crinecerfont in pediatric and adult congenital adrenal hyperplasia, the postacute sequelae of SARS-CoV-2 infection, and nipocalimab in early-onset severe hemolytic disease of the fetus and newborn; a review article on frailty in older adults; a case report of a woman with postpartum anxiety and intrusive thoughts; and Perspectives on refusing to learn the lessons of Covid-19; on preparing for the next pandemic; on collective trauma and commemoration; and on an unknown family history.

Featuring articles on belantamab mafodotin for multiple myeloma, autoantibodies targeting nephrin in podocytopathies, neutralizing anti–interleukin-10 autoantibodies in IBD; a review article on Parkinson’s disease; a Clinical Problem-Solving on going down the rabbit hole; a Medicine and Society article on race-based screening under the ethics microscope; and a Perspective on a legacy of cruelty to sexual and gender minority groups.

Featuring articles on treatments for metabolic dysfunction–associated steatohepatitis, blinatumomab in adults with ALL, and sotorasib for KRAS G12C–driven vascular malformations; a review article on HIV-associated tuberculosis; a case report of a woman with rapidly progressive dementia; and Perspectives on the abandonment of people subjected to sexual and intimate partner violence, on multicancer early detection tests, and on coping in the setting of serious illness.