Featuring articles on treatments for atrial fibrillation and stable coronary disease, for chronic hepatitis B, and for metastatic breast cancer; the 30-year cardiovascular disease risk in healthy women; and prenatal screening and detection of maternal cancer; a review article on sepsis and septic shock; a case report of a woman with headache, fever, and respiratory failure; and Perspectives on Medicare’s bundled-payment programs, on handcuffs and unexpected deaths, on the Marburg outbreak in Rwanda, and on the care that saved one parent.

Featuring articles on pembrolizumab perioperative therapy in breast cancer, reduced dose schedules or fractional doses of pneumococcal conjugate vaccine, and nivolumab plus ipilimumab in colorectal cancer; a review article on degenerative rotator-cuff disorders; a case report of a man with seizures and agitation; a Clinical Implications of Basic Research on boning up on boning up; and Perspectives on the Duffy null phenotype; on sickle cell trait, inequity, and the need for change, on “target trial emulation” for observational studies, and on a good day.

Featuring articles on perioperative durvalumab in bladder cancer, transcatheter valve repair for mitral regurgitation, chemoradiotherapy in gastric cancer, and lessons from England’s National Health Service; a review article on lung transplantation; a case report of a newborn with hypoxemia and a lung opacity; and Perspectives on our latest brief case studies on efforts toward equity and on forensic nurse examiners.

Featuring articles on an invasive treatment strategy in older patients with myocardial infarction, a randomized trial of very early medication abortion, therapies in stage III melanoma, and on long Covid defined; a review article on uterine fibroids; a Clinical Problem-Solving on two sides to the story; and Perspectives on the U.S. Latino HIV crisis, on reframing cerebral palsy as a lifelong disability, and on an older patient and his physician finding an immediate, resonant connection in a haunting song recalled from long ago and far away.

Featuring articles on semaglutide in persons with obesity and knee osteoarthritis, the addition of PI3K inhibition in breast cancer, treatments in older patients with myeloma, and total hip replacement for hip osteoarthritis; a review article on lead poisoning; a case report of a man with dyspnea after old myocardial infarction; and Perspectives on large language models and the medical record, on measuring AI against the health care we have, on the failing U.S. health system, and on the contemporary rise of pronatalism.

Featuring articles on treatments in heart failure, advanced non–small-cell lung cancer, and Dupuytren’s contracture; a neurodevelopmental disorder caused by deletion in a long noncoding RNA; a review article on burnout and depression among physicians; a case report of a woman with confusion, aphasia, and a brain mass; a Medicine and Society article on how the idea of social contagion shaped trans medicine; and Perspectives on navigating clinicians’ conscience-based refusals, on opportunity costs of Medicare Advantage rebates, on celebrating public health, and on taking our own medicine.

Featuring articles on nivolumab in advanced Hodgkin’s lymphoma, kidney transplantation from donors with HIV, a modular communicative leadless pacing–defibrillator system, stereotactic body radiotherapy in prostate cancer, and on how DNA sensing drives inflammation; a review article on cryoglobulinemia; a case report of a woman with dyspnea, dysphagia, and dysarthria; and a Special Report and Perspectives on the U.S. elections and health policy.

Featuring articles on beta-blocker use after myocardial infarction and treatments for cerebral adrenoleukodystrophy and for small-cell lung cancer; a review article on hairy-cell leukemia; a case report of a man with fever, myalgia, jaundice, and respiratory failure; and Perspectives on Mpox, on addressing health care cost growth, and on confirmatory trials of accelerated approval drugs.

Featuring articles on lenacapavir for HIV prevention in cisgender women, tirzepatide for treatment of obstructive sleep apnea, lymphadenectomy for muscle-invasive bladder cancer, secondary T-cell lymphoma after CAR T-cell therapy, and immunity and early colorectal carcinogenesis; a review article on prolonged grief disorder; a Clinical Problem-Solving on avoiding rash decisions; and Perspectives on health care reform and the 2024 U.S. elections, on financial toxicity for patients from the use of AI, on the Supreme Court’s shadowy treatment of public health, and on caring for our communities.

Featuring articles on systematic vs. targeted biopsy for prostate cancer screening, ziresovir in hospitalized infants with RSV, gene therapy for factor IX deficiency, and a phase 2 trial of tulisokibart for ulcerative colitis; a review article on neuroleptic malignant syndrome; a case report of a woman with kidney lesions and lytic bone disease; and Perspectives on Dobbs revisited, on the role of physicians on ethics committees after Dobbs, on accessible weight scales and exam tables, and on ensuring a safe and sufficient global blood supply.