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Building Solutions to Chronic Pain Through Clinical Research
In this week's episode, we explore how pain works, some of the causes of pain, and some of the possible solutions to chronic pain. We look at the who, what, and the how of pain in the body - and how its a brain process as much has in the body process.
References:
Kuner, R., & Flor, H. (2017). Structural plasticity and reorganisation in chronic pain. Nature Reviews Neuroscience, 18(1), 20-30. https://www.nature.com/articles/nrn.2016.162
Borges, J. P., Mekhail, K., Fairn, G. D., Antonescu, C. N., & Steinberg, B. E. (2021). Modulation of pathological pain by epidermal growth factor receptor. Frontiers in Pharmacology, 12, 642820. https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.642820/full
Kandel, E. R., Schwartz, J. H., Jessell, T. M., Siegelbaum, S., Hudspeth, A. J., & Mack, S. (Eds.). (2000). Principles of neural science (Vol. 4, pp. 1149-1159, 1227-1246). New York: McGraw-hill.
Johnson, M. I. (2019). The landscape of chronic pain: broader perspectives. Medicina, 55(5), 182. https://www.mdpi.com/1648-9144/55/5/182
Knopp, K. L., Downing, A. M., Anthony, L., Chaterjee, S., Price, K., & Sparks, J. (2024). An innovative phase 2 chronic pain master protocol design to assess novel mechanisms in multiple pain types. Pain Reports, 9(6), e1203.https://pmc.ncbi.nlm.nih.gov/articles/PMC11487222/
Rikard, S. M. (2023). Chronic pain among adults—United States, 2019–2021. MMWR. Morbidity and Mortality Weekly Report, 72. https://pmc.ncbi.nlm.nih.gov/articles/PMC10121254/
Apkarian, A. V., Baliki, M. N., & Geha, P. Y. (2009). Towards a theory of chronic pain. Progress in neurobiology, 87(2), 81-97. https://www.sciencedirect.com/science/article/abs/pii/S0301008208001135
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By MedEvidence ArticlesIn this week's episode, we explore how pain works, some of the causes of pain, and some of the possible solutions to chronic pain. We look at the who, what, and the how of pain in the body - and how its a brain process as much has in the body process.
References:
Kuner, R., & Flor, H. (2017). Structural plasticity and reorganisation in chronic pain. Nature Reviews Neuroscience, 18(1), 20-30. https://www.nature.com/articles/nrn.2016.162
Borges, J. P., Mekhail, K., Fairn, G. D., Antonescu, C. N., & Steinberg, B. E. (2021). Modulation of pathological pain by epidermal growth factor receptor. Frontiers in Pharmacology, 12, 642820. https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.642820/full
Kandel, E. R., Schwartz, J. H., Jessell, T. M., Siegelbaum, S., Hudspeth, A. J., & Mack, S. (Eds.). (2000). Principles of neural science (Vol. 4, pp. 1149-1159, 1227-1246). New York: McGraw-hill.
Johnson, M. I. (2019). The landscape of chronic pain: broader perspectives. Medicina, 55(5), 182. https://www.mdpi.com/1648-9144/55/5/182
Knopp, K. L., Downing, A. M., Anthony, L., Chaterjee, S., Price, K., & Sparks, J. (2024). An innovative phase 2 chronic pain master protocol design to assess novel mechanisms in multiple pain types. Pain Reports, 9(6), e1203.https://pmc.ncbi.nlm.nih.gov/articles/PMC11487222/
Rikard, S. M. (2023). Chronic pain among adults—United States, 2019–2021. MMWR. Morbidity and Mortality Weekly Report, 72. https://pmc.ncbi.nlm.nih.gov/articles/PMC10121254/
Apkarian, A. V., Baliki, M. N., & Geha, P. Y. (2009). Towards a theory of chronic pain. Progress in neurobiology, 87(2), 81-97. https://www.sciencedirect.com/science/article/abs/pii/S0301008208001135