In this chapter, we talk about "Tendon healing: Repair and Regeneration." This takes a chapter from a volume of "The Annual Review of Biomedical Engineering"
Injury and degeneration of tendon, the soft tissue that mechanically links
muscle and bone, can cause substantial pain and loss of function. This review
discusses the composition and function of healthy tendon and describes the
structural, biological, and mechanical changes initiated during the process of
tendon healing. Biochemical pathways activated during repair, experimental
injury models, and parallels between tendon healing and tendon develop-
ment are emphasized, and cutting-edge strategies for the enhancement of
tendon healing are discussed.