Hiss & Tell: Cat Behavior and Beyond

Cat Anxiety, Aggression & Medication with Dr. Sagi Denenberg


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Cat aggression, overgrooming, and litter box “problems” are easy to label and surprisingly hard to solve, especially when we treat the behavior as the diagnosis. We sit down with veterinary psychiatrist Dr. Sagi Dennenberg to get underneath the label and into what’s actually driving the cat’s behaviors: fear, anxiety, frustration, learned patterns, pain, and even underdiagnosed skin disease.

We talk about why behavior and physical health are inseparable in cats, including how stress can skew vital signs and lab results and why “my cat is not herself” can be an early warning sign before anything obvious shows up on an exam. Sagi explains what a true behavioral diagnosis looks like, why home observation and video can reveal subtle pain, and how clinicians can avoid the trap of calling something “psychogenic” too quickly.

Then we demystify psychoactive medications for cats. We cover what meds can realistically do (normalize biological behaviors and lower emotional intensity) and what they cannot do (teach skills or replace behavior modification). You’ll hear how diagnosis guides medication choice, what to expect from SSRIs like fluoxetine, how to think about timelines and tapering, and why many “side effects” are actually a return to normal sleep and eating patterns. We also get practical about dosing challenges, including when transdermal medications may help and when they can backfire, especially in multicat homes.

If you’ve felt unsure about cat behavior meds, worried about side effects, or stuck with an ongoing behavior issue, this conversation will give you a clearer framework and more confidence in your next steps. Subscribe for more, share this with a fellow cat person, and leave a rating or review so more listeners can find the show.

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Hiss & Tell: Cat Behavior and BeyondBy Kristiina Wilson

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