Science Friday

In 2022, the Nobel Prize in Chemistry went to Dr. Carolyn Bertozzi of Stanford University, Dr. Morten Meldal of the University of Copenhagen, and Dr. K. Barry Sharpless of the Scripps Research Institute “for the development of click chemistry and bioorthogonal chemistry.” In “click chemistry,” molecular building blocks snap together quickly and efficiently to let chemists build more complicated molecules. But bioorthogonal chemistry takes that work one step further, allowing the technique to be used within living organisms without damaging cells.

“When someone is thinking outside the box, or in a very different way, we like to think of that as orthogonal thinking,” Bertozzi explained. “So biorthogonal means not interacting with biology. Totally separate from biology.” Her research began with an interest in developing ways to see specific sugar molecules on the surface of cells. But it has developed into an approach that can be used for advanced drug delivery in fields such as chemotherapy.

As part of Science Friday’s 33rd anniversary show, we’re revisiting our listeners’ favorite stories, including this one. In 2022, Bertozzi joined Ira Flatow for a wide-ranging conversation about her research, chemistry education, her early music career, and the importance of diversity in the field of chemistry.

Transcripts for each segment will be available after the show airs on sciencefriday.com.

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In 2018, actor, author and science communicator Alan Alda spoke publicly about his diagnosis for Parkinson’s Disease. Alda, who is best known for his role in “M*A*S*H,” “The Aviator,” and “The West Wing,” shifted his interests to science communication in his later years. He’s written several books on the topic, and has an ongoing podcast, “Clear + Vivid.”

As part of Science Friday’s 33rd anniversary show, we’re revisiting our listeners’ favorite stories, including this one. Alda came on Science Friday in 2018 to talk about his life since his Parkinson’s diagnosis, and how being an advocate for science changes his perspective on his condition. 

Transcripts for each segment will be available after the show airs on sciencefriday.com.

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Just in time for Thanksgiving, a potato researcher explains potato varieties, potato nutrition, and some tubular tuber facts. And, irregular, fatty marbling gives meat a unique texture. Recreating that in plant-based products isn’t easy.

The potato is a versatile vegetable—baked, roasted, fried, mashed—it can bring something to just about any menu. But, how exactly do these tasty tubers end up on our tables? We’ll give you a crash course in potato science, including how potatoes are grown (hint: not from seeds!) and what scientists look for when they develop new potato varieties.

SciFri producer Kathleen Davis talks with Dr. Rhett Spear, assistant professor in the Plant Sciences Department at the University of Idaho. 

Plant-based meat products have evolved over the past few decades. You can find them in many forms, like sausages, deli meats, and faux chicken nuggets. During the holiday season, no plant-based meat is more famous than the Tofurky Roast, a round imitation turkey.

Despite improvements in flavor for plant-based meat products, there are still lots of challenges to getting fake meats to mimic their real counterparts. One tough one is textural: instilling a marbling effect. This is the effect of irregular fat deposits, which occur naturally in animal meat.

Plant-based meat has a uniform texture by design. Because each product is processed to be a certain way, the randomness and irregularity of fat pockets is taken out of the equation. But some food scientists are working on adding more of this meaty texture to plant-based meat.

Joining guest host Kathleen Davis to discuss the challenges and possibilities for the next stage of plant-based meat is Dr. David Julian McClements, distinguished professor in food science at the University of Massachusetts Amherst.

Transcripts for each segment will be available after the show airs on sciencefriday.com.

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We recently asked our listeners which dubious health claims they’ve been seeing in their social media feeds or being circulated by friends and family. Unsurprisingly, we received a ton of questions about nutrition, including: Is seed oil bad for you? Does apple cider vinegar really lower blood sugar? What is the difference between processed and ultraprocessed foods? 

To answer those questions and more, SciFri producer Kathleen Davis talks with RDN Jessica Clifford, a nutrition specialist at Department of Food Science and Human Nutrition at Colorado State University. 

Transcripts for each segment will be available after the show airs on sciencefriday.com.

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Fifty-three days after Hurricane Helene, residents of Asheville can safely drink their tap water without boiling it. Why did it take so long? And, tribes’ historic lands on the Gulf Coast are being lost to the sea. To slow it down, one tribe has turned to oyster shells.

When Hurricane Helene barrelled through the southeastern US in September, it dumped an estimated 40 trillion gallons of water on the region. That resulted in immense flooding that destroyed roads, buildings, power lines, and other infrastructure.

And it also impacted the region’s potable water supply. For weeks, residents in Asheville, North Carolina, didn’t have access to clean drinking water because the extensive flooding washed large amounts of sediment into the local reservoir. As of Monday, limited access to potable water was restored, marking the first time in 53 days that local residents didn’t have to boil tap water to drink it.

Before that access was restored, we heard from listeners Sarah and Alison in Asheville who had their own questions about the water quality in their city, and the science behind sediment issues in a local reservoir.

Guest host and SciFri producer Kathleen Davis is joined by Dr. Sarah Ledford, associate professor of geosciences at Georgia State University, to figure out why it can take so long for cities to clean their potable water after a storm like this and what other regions expect from the aftermath of future extreme weather.

On a hot Friday morning, the sun beat down on volunteers gathered at the edge of the water in southern Plaquemines Parish. They passed heavy sacks of oyster shells to each other down a line. The volunteers loaded the shells onto boats to use them for building an oyster reef to help slow land loss in Grand Bayou Indian Village.

“The oyster reef is a living thing. Baby oysters are going to attach to it. It’s going to grow. It’s going to become bigger,” said James Karst with the Coalition for Coastal Louisiana, the organization that built the reef. “But when the sea level rises, because oysters are growing on it, it will grow vertically as well, so it will continue to add protection.”

Louisiana’s land loss is an existential crisis for many of the tribes who live along the coast. Grand Bayou Indian Village, a small community, home to the Atakapa-Ishak/Chawasha tribe, is watching its lands wash away. Nearly 1,000 people lived in the village in the 1940s, but now there are only about a dozen homes raised on stilts right along the edge of the bayou. Boats are the only way to get around.

“You can look at the GPS and it will indicate a different color for where land is,” said Karst. “You’ll be looking at this on the screen, then you’ll look up and there is no land there. It’s just open water.”

Volunteers built the reef by stacking bags of recycled oyster shells in the water, up and down the shoreline. The shells came from restaurants in New Orleans. The coalition recently expanded its oyster recycling services to Baton Rouge.

Read the full story at sciencefriday.com.

Transcripts for each segment will be available after the show airs on sciencefriday.com.

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On November 24, 1974—50 years ago this November—a pair of paleoanthropologists made the discovery of a lifetime: a set of 47 bones, hidden in the dusty, rocky hills of a fossil site in Hadar, Ethiopia. The skeleton belonged to a 3.2 million year old hominin, which came to be nicknamed Lucy.

She marked the very first specimen of Australopithecus afarensis—a species of early hominins that were very likely our own ancestors. Lucy might be the most famous fossil in the world, and she’s transformed our understanding of human evolution.

SciFri’s Kathleen Davis looks back at 50 years of Lucy with the people who know her best: Dr. Donald Johanson, founding director of the Institute of Human Origins at Arizona State University and the paleo legend who discovered her, as well as Dr. Zeray Alemseged, paleoanthropologist at the University of Chicago who discovered “Lucy’s baby.” They discuss what Lucy has taught us in the last 50 years, why she remains a scientific icon, and how understanding our ancestral origins helps us understand humanity.

Transcripts for each segment will be available after the show airs on sciencefriday.com.

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This was the sixth test launch of the Starship vehicle, which could eventually carry humans and cargo to the moon. It was extremely loud. Also, divers have recovered seeds of a long-lost rye variety from a 146-year-old shipwreck in Lake Huron. Scientists hope to bring it back to life.

On Tuesday, the rocket company SpaceX conducted another test flight of its Starship spacecraft. In the uncrewed mission, the sixth test of the system, the company was seeking to test its ability to restart the Starship engines while in orbit, a function that’s necessary for in-space maneuvering. The rocket did launch successfully, and the engine test worked. However, at the last minute the company elected not to try to repeat an October maneuver in which it caught a returning SuperHeavy rocket booster at the launch tower, citing safety concerns.

SciFri’s Charles Bergquist joins guest host Kathleen Davis to talk about the launch, and related research into the tremendous sound created by the system’s launch and reentry. They also discuss other stories from the week in science, including the discovery of a saber-toothed kitten in Siberian permafrost, efforts to use light to help destroy PFAS chemicals, a company using Pokemon Go game data to train an AI, and more.

In 1878, a wooden schooner named the James R. Bentley set sail from Chicago to Buffalo, New York. But strong winds and rough waters damaged the ship, and it sank to the bottom of Lake Huron. The crew was saved, but the ship’s cargo—a large shipment of rye—sank with it. In the years since the shipwreck, that particular variety of rye has faded out of existence.

Now, almost 150 years later, a Michigan-based team is trying to bring the long-lost rye back to life. They dove to the shipwreck, retrieved a tube full of seeds, and are planning to use gene technology to recreate the rye variety. Their goal is to encourage farmers to grow it, so that distillers can use it to make whiskey.

SciFri producer Kathleen Davis talks with Dr. Eric Olson, professor of wheat breeding and genetics at Michigan State University, and Chad Munger, founder and CEO of Mammoth Distilling.

Transcripts for each segment will be available after the show airs on sciencefriday.com.

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What’s the secret to making a fluffy omelet or the perfect pie dough? In this interview from 2012, Jack Bishop, now senior content advisor at America’s Test Kitchen, debunks cooking myths and highlights some of the surprising finds from the show’s cookbook, The Science of Good Cooking.

Bishop tells us that water is one of the key parts of the perfect pie crust. You need it to roll out the dough, but it also forms gluten which makes the dough chewy. So, how can your pie dough be both soft and easy to handle? Use science—and a little bit of vodka.

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It sounds like something from an advertisement for bathroom cleaner: Researchers found over 600 different viruses, most of which are new to science, in samples taken from showerheads and toothbrushes. The viruses, however, are unlikely to affect humans. They are bacteriophages, a type of virus that preys on bacteria. The expedition into bathroom biodiversity was recently published in the journal Frontiers in Microbiomes.

Around a hundred years ago in the former Soviet Union, there were major efforts to develop bacteriophages for medical use. The approach really didn’t catch on in Western countries, overshadowed there by the rise of conventional antibiotics like penicillin. But with some diseases developing resistance to those conventional antibiotics, there’s been increased interest in phages as part of an antibacterial toolkit.

Dr. Erica Hartmann, an associate professor in the department of Civil & Environmental Engineering at Northwestern University, joins Ira to talk about what researchers found when they took a close look at a collection of bathroom samples, and how phage research has advanced in recent years.

Transcript for this segment will be available after the show airs on sciencefriday.com.

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Researchers are connecting two ecological problems in the Northeast in hopes of reducing the risk of tick-borne illnesses. Also, a “one-of-a-kind” fossil of Navaornis hestiae helps fill a giant gap in scientists’ understanding of how bird brains evolved.

In much of the eastern US, October and November usher in an autumn peak of the blacklegged tick season.

For years, researchers have noticed that these ticks, also called deer ticks, are more abundant on certain invasive plant species, like Japanese barberry, that create dense thickets in the forest understory. 

Now, a group of scientists in Vermont and Maine is investigating how managing these plants might decrease the number of blacklegged ticks—and the risk of people developing tick-borne illnesses, like Lyme disease and Babesiosis. After getting a $1.8 million grant from the National Science Foundation, they’re hoping to come up with guidance for landowners.

Read the rest at sciencefriday.com.

Archaeopteryx is the earliest bird-like dinosaur that we know of. It lived 150 million years ago, but researchers don’t know much about how the bird brain evolved from then to now.

An 80 million-year-old bird from the Mesozoic Era is now helping fill in the blanks. It’s called Navaornis hestiae. Researchers uncovered a fossil of this species, which was previously unknown to science, in Brazil in 2016. That specimen has a remarkably well-preserved skull, which a team of paleontologists used to digitally reconstruct the bird’s brain. The researchers recently reported their findings in the journal Nature.

Ira talks with a lead author of the study, Dr. Luis Chiappe, a paleontologist and curator at the Natural History Museum of Los Angeles County in California.

Transcripts for each segment will be available after the show airs on sciencefriday.com.

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