Astrophysicists may have spotted evidence for “dark stars,” an unusual type of star that could possibly have existed in the earliest days of the universe, in data from the James Webb Space Telescope. Instead of being powered by nuclear fusion as current stars are, the controversial theory says that these ancient dark stars would have formed by mixing a huge cloud of hydrogen and helium with a type of self-annihilating dark matter. Dark stars would not have been dark—researchers believe that if they existed, they would actually have been bigger and brighter than current stars.

Astrophysicists Katherine Freese, who first proposed the idea of dark stars in 2007, and Cosmin Ilie, who detected the possible signs of the dark stars, join Host Ira Flatow to discuss the theory.  

Guests:
Dr. Katherine Freese is a theoretical astrophysicist and a professor of physics at the University of Texas at Austin.
Dr. Cosmin Ilie is an assistant professor of physics and astronomy at Colgate University.

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AI is everywhere these days, and though there’s debate about how useful it is, one area where experts think it could be game-changing is scientific research. It promised to be particularly useful for speeding up drug discovery, an expensive and time-consuming process that can take decades. But so far, it hasn’t panned out.

The few AI-designed drugs that have made it to clinical trials haven’t been approved, venture capital investment in these efforts has cratered in the last few years, and many startups have shut their doors. So why has it been so hard to make AI-designed drugs? What are the fundamental issues, and what does the future of this research look like?

Joining Host Ira Flatow with some answers is Peter Coveney, who studies how chemistry discoveries can be sped up with algorithms and computers.

Guest: Dr. Peter Coveney is a professor and director of the Centre for Computational Science at University College London.

Transcripts for each episode are available within 1-3 days at sciencefriday.com.

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It’s easy to take maps for granted. After all, most of us have a pretty good map in our pockets at all times, ready to show us how to get anywhere on the globe. But to make a map useful, you have to decide what to keep in and what to leave out—and, most importantly, which mathematical equations to use. Beyond navigating from point A to point B, math and maps come together for a wide variety of things, like working out the most efficient route to deliver packages, calculating the depth of the ocean floor, and more. 

Host Ira Flatow is joined by Paulina Rowińska, mathematician and author of Mapmatics: A Mathematician's Guide to Navigating the World, to go on a journey through the math at the heart of all kinds of maps. 

Guest: Dr. Paulina Rowińska is a mathematician, writer, science journalist and author of Mapmatics: A Mathematician's Guide to Navigating the World.

Transcripts for each episode are available within 1-3 days at sciencefriday.com.

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It seems like every week, there’s a new headline about some kind of sci-fi-esque organ transplant. Think eyeballs, 3D-printed kidneys, pig hearts.

In her new book, Replaceable You: Adventures in Human Anatomy, science writer Mary Roach chronicles the effort to fabricate human body parts—and where that effort sometimes breaks down. Host Flora Lichtman speaks with Roach about everything from hair transplants to 3D-printed hearts, and why our anatomy is so hard to replicate in the first place.

Guest: Mary Roach is a science writer and the author of Replaceable You: Adventures in Human Anatomy.

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Remember “The Biggest Loser”—the show where people tried to lose as much weight as quickly as possible for a big cash prize? The premise of the show was that weight loss was about willpower: With enough discipline, anyone can have the body they want.

The show’s approach was problematic, but how does its attitude toward weight loss match our current understanding of health and metabolism? The authors of the book Food Intelligence, nutrition scientist Kevin Hall, who studied “Biggest Loser” contestants at the NIH; and science writer Julia Belluz, join Host Flora Lichtman and answer listener questions about nutrition, diet fads, and metabolism.

Read an excerpt of Food Intelligence: The Science of How Food Both Nourishes and Harms Us.

Guests:
Julia Belluz is a science journalist based in Paris.
Dr. Kevin Hall is a nutrition scientist and former NIH researcher based in Kensington, Maryland.

Transcripts for each episode are available within 1-3 days at sciencefriday.com.

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In July 1925, physicist Werner Heisenberg wrote a letter to Wolfgang Pauli sharing his new ideas about what would eventually become known as quantum theory. A hundred years later, that theory has been expanded into a field of science that explains aspects of chemical behavior, has become the basis of a new type of computing, and more. But it’s still really weird, and often counterintuitive. Physicist Chad Orzel joins Host Ira Flatow to celebrate 100 years of quantum science, and separate quantum fact from science fiction.

Guest: Dr. Chad Orzel is the R. Gordon Gould Associate Professor of Physics and Astronomy, and chair of the department, at Union College in Schenectady, New York.

Transcripts for each episode are available within 1-3 days at sciencefriday.com.

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This year’s Nobel Prize in Physiology or Medicine went to three people whose combined discoveries outlined the role of the peripheral immune system—how the immune system knows to attack just foreign invaders and not its own tissues and organs. But when the phone rang for Shimone Sakaguchi, Mary E. Brunkow, and Fred Ramsdell, only two of them picked up.

Host Ira Flatow talks with Nobel Prize winner Fred Ramsdell, co-founder and scientific advisor at Sonoma Biotherapeutics.

Plus, Ira talks with bioengineering professor César de la Fuente, who looks for solutions to the antibiotic resistance crisis in unexpected places. Now, he’s used AI to help identify promising antibiotic candidates lurking in ancient archaea, small organisms that can survive some of the most extreme conditions in the world.

Guests:
Dr. Fred Ramsdell is the co-founder and scientific advisor at Sonoma Biotherapeutics.
Dr. César de la Fuente is an associate professor of bioengineering at the University of Pennsylvania.

Transcripts for each episode are available within 1-3 days at sciencefriday.com.

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It’s World Space Week, and we’re fueling up the rocket for a tour of some missions and projects that could provide insights into major space mysteries. Astrophysicist Hakeem Oluseyi joins Host Flora Lichtman to celebrate the wonders of space science, from the recently launched IMAP, which will study the solar environment, to the new Vera Rubin Observatory, and big physics projects like LIGO. 

Plus, the latest in climate tech: MIT Technology Review has published its annual list of climate tech companies that show great promise in work ranging from producing sodium ion batteries to recycling rare earth magnets. Host Ira Flatow talks with climate reporter Casey Crownhart about trends in climate tech and what companies she’s excited about.

Guests: Dr. Hakeem Oluseyi is an astrophysicist and author of the upcoming book, Why Do We Exist? The Nine Realms of the Universe That Make You Possible, and host of the video podcast “Particles of Thought.”
Casey Crownhart is a senior climate reporter for MIT Technology Review based in New York City.

Transcripts for each episode are available within 1-3 days at sciencefriday.com.

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The Klamath River, which runs from southern Oregon to California, used to be a top salmon run. But after a series of hydroelectric dams was installed along the river around 100 years ago, salmon populations tanked.

This is the prologue to a remarkable story of a coalition that fought to restore the river. Led by members of the Yurok Nation, who’ve lived along the river for millennia, a group of lawyers, biologists, and activists successfully lobbied for the removal of the dams. The fourth and final dam was taken down last year.

Joining Host Flora Lichtman to go behind the scenes of the dam removal and what’s happened since are Amy Bowers Cordalis, former general counsel for the Yurok Nation and author of the forthcoming book The Water Remembers: My Indigenous Family’s Fight to Save a River and a Way of Life; and Barry McCovey Jr., director of the Yurok Tribes Fisheries Department.

Read an excerpt from The Water Remembers: My Indigenous Family’s Fight to Save a River and a Way of Life.

Guests:

Amy Bowers Cordalis is an attorney, member of the Yurok Nation, and author of The Water Remembers: My Indigenous Family’s Fight To Save A River And A Way Of Life. 
Barry McCovey Jr. is the director of the Yurok Tribes Fisheries Department, based in Klamath, California.

Transcripts for each episode are available within 1-3 days at sciencefriday.com.

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Archeologists in movies have a reputation for being hands-on, like Indiana Jones unearthing hidden treasure, or Lara Croft running through a temple. Archeology in real life tends to be a bit more sedentary. But some archeologists are committed to getting their hands dirty—even recreating the stinky, slimy, and sometimes tasty parts of ancient life.

Science writer Sam Kean enmeshed himself in the world of experimental archaeology for his new book Dinner with King Tut: How Rogue Archaeologists are Recreating the Sights, Sounds, Smells, and Tastes of Lost Civilizations. He joins Host Ira Flatow to discuss making stone tools, launching catapults, and DIY mummies.

Guest: Sam Kean is a science writer and author of Dinner with King Tut: How Rogue Archaeologists are Recreating the Sights, Sounds, Smells, and Tastes of Lost Civilizations. 

Transcripts for each episode are available within 1-3 days at sciencefriday.com.

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