Cell Podcast

In this month's Cell Podcast, we learn about how SUMOlyation wrestles hedgehog signaling into the right location during endocrine development, with Holly Ingraham (0:00), how neural stem cell progenitors are protected during starvation, from Alex Gould (12:01), and what's required in AML to make a cell susceptible to oncogenic transformation, explains Keith Humphries (17:48).

In this month's Cell Podcast, we learn about a lysosomal thread linking synucleinopathies, with Dimitri Krainc (0:00) (Mazzulli et al.), the genetics of human height, with Valerie Cormier-Daire (8:00), and polar bears: getting in touch with their surprising origins, with Beth Shapiro (14:31).

In this month's Cell Podcast, we learn about getting neural stem cells out of the lab and into the clinic, with Sally Temple (0:00), an important role for rare copy number variations in autism, with Matthew State and Michael Wigler (8:30), the dangers of midnight feasts for fruit fly fertility, with Amita Sehgal (18:04), and fitness costs and crosstalk in the evolution of host defense pathways, with Ruslan Medzhitov (24:32).

In this month's Cell Podcast, we learn about ape droppings and the origins of malaria, with Julian Rayner (0:00), A next-gen sequencing technique to study high-speed gene expression, with W. Lee Kraus (9:35), and Tracing the evolution of signaling pathways in plants, with Alistair Hetherington (15:56).

In this month's Cell Podcast, we learn about how HIV hides in hempatopoietic stem cells (0:00), combating tuberculosis drug resistance (7:25), and suppressing tumors with a protein isomerase (13:41).

Cellular "coin-flipping;" Jim Collins explains how cells make decisions (0:00), the vicious cycle of treating drug addiction as a criminal behavior, instead of a medical condition (8:23), and how small molecules can help uncover signaling crosstalk, when genetic strategies fail (16:56).

Engineering cyanobacteria to a make a profit—not just biofuels (0:00), why breast cancers often metastasize to the bone (11:03), and EPO's surprising anti-inflammatory properties (17:15).

Hunting down biomarkers for Alzheimer's diease (0:30), modeling Progeria with iPS cells (10:13), and how yeast spare their daughter cells from toxic aging factors (16:52).

Hear about filling in the gaps of the 1000 genomes project (0:50), learn about tracking down an elusive culprit of inherited diseases. (10:05), discover how chromatin-modifying enzymes orchestrate skin development (18:22).

Learn how skeletal stem cells are key to improving osteoporosis treatment regimes (1.00), discover what a new pain gene has in common with Hungarian composer Franz Liszt (10.33), and hear insights from new metabolomics analysis of the tuberculosis pathogen (17:51).