The sermon centers on the biblical command to 'despise not prophesying,' emphasizing that rejecting or dismissing the Word of God—whether through indifference, resistance, or selective acceptance—is a profound spiritual danger rooted in humanity's oldest sin. Drawing from 1 Thessalonians 5:20 and a wide range of Scripture, it argues that prophesying, as the inspired and authoritative revelation of God, is not merely human teaching but the very voice of divine wisdom, and to disdain it is to reject God's guidance, wisdom, and grace. The message traces this attitude from Adam and Eve's disobedience to the hardening of Pharaoh, the rejection of prophets by Israel, and the modern tendency to treat Scripture as outdated or irrelevant, all of which result in spiritual blindness, unrepentant living, and the ineffectualness of God's Word in one's life. Ultimately, the sermon calls believers to embrace the Word not as a mere text but as a living, transformative force, urging a posture of faith, obedience, and delight in Scripture, for only through such a heart can the blessings of salvation and sanctification be realized, while the consequences of rejection are inevitable.