Dr. Barbara Moscicki discusses the critical role of HPV in women's health, particularly its association with various cancers, including cervical cancer. She explains the dual nature of HPV as both a commensal organism and a pathogen, emphasizing the importance of understanding its oncogenic potential. The conversation also covers the significance of screening methods, such as Pap smears, in detecting precancerous changes and the complexities surrounding the treatment of different cervical intraepithelial neoplasia (CIN) stages. This conversation delves into the complexities of cancer screening methods, particularly focusing on cervical and anal cancer. Dr. Barbara Moscicki discusses the importance of understanding various screening guidelines, the role of HPV vaccination in preventing cancers, and the need for clear communication between clinicians and patients regarding these topics. The discussion highlights the evolving nature of cancer screening practices and the importance of patient education in navigating these changes.

About Our Guest:

Dr. Moscicki is a Pediatrician, Board Certified in Adolescent Medicine. She is the current Division Chief of Adolescent and Young Adult Medicine with clinical expertise in reproductive health care for menstrual irregularities, sexual health, and sexually transmitted diseases. Dr. Moscicki has expertise in HPV -related disease including diagnosis of cervical dysplasia and treatment. She also offers medical care for women with eating disorders.

Resources & Links:

This episode was supported by the Patient Centered Outcomes Research Institute (PCORI) and features the PCORI research study here: https://pubmed.ncbi.nlm.nih.gov/33632649/ ‘Effect of 2 Interventions on Cervical Cancer Screening Guideline Adherence’Chapter Codes

00:00 Introduction to HPV and Women's Health

03:00 Understanding HPV's Role in Cancer

06:01 The Dual Nature of HPV: Commensal vs Pathogenic

08:57 Oncogenes and Their Impact on Cellular Regulation

12:09 The Intersection of HPV and Screening Methods

14:58 Cervical Cancer Screening and Pap Smears

20:30 Understanding Cancer Screening Methods

23:17 Guidelines for Cervical and Anal Cancer Screening

31:02 The Importance of HPV Vaccination

39:35 Key Messages for Clinicians and Patients

Takeaways

- Dr. Moscicki specializes in adolescent and young adult medicine.

- HPV is linked to multiple cancers beyond cervical cancer.

- The understanding of HPV's role in cancer has evolved significantly.

- E6 and E7 proteins from HPV disrupt normal cell regulation.

- CIN3 is considered a true pre-cancer that requires treatment.

- Liquid cytology has improved the accuracy of Pap smears.

- CIN1 is often self-resolving and does not require treatment.

- CIN2 presents a diagnostic dilemma due to variability in interpretation.

- Women have options regarding the management of CIN2 lesions.

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Disclaimer:

All content and information provided in connection with Manta Cares is solely intended for informational and educational purposes only. This content and information is not intended to be a substitute for medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

This episode was supported by an award from the Patient-Centered Outcomes Research Institute.