What Messes With Autophagy: What the Research Says Welcome to CFP Weight Loss. I'm Russell Clark, Nurse Practitioner. Today, we're exploring What Messes With Autophagy: What the Research Says. ... Take a breath, settle in, and let's walk through this together — clearly, calmly, and based on what the evidence actually shows. ... We'll touch on Autophagy, Insulin Resistance, Intermittent Fasting — especially as they apply to real people over forty. ... Autophagy is your body’s sophisticated cellular housekeeping system. It identifies damaged proteins, dysfunctional mitochondria, and other cellular debris, then breaks them down for recycling or energy. For adults in their mid-40s to mid-50s navigating hormonal shifts, rising insulin resistance, chronic inflammation, joint discomfort, and stubborn weight, optimized autophagy can dramatically improve metabolic flexibility, insulin sensitivity, and sustainable fat loss. ... Research consistently shows that after age 45, declining growth hormone, elevated cortisol, and accumulated cellular damage blunt this process. When autophagy runs efficiently, the body clears inflammation-promoting waste and burns stored fat more readily between meals. Listen at CFP Weight Loss — clinical guide with Russell Clark, FNP-C. Read more: https://blog.cfpweightloss.com/what-messes-with-autophagy-what-the-research-says