Metabolic Reset with Dual GIP/GLP-1 Agonists: Practical Protocol for Midlife PCOS Patients Welcome to CFP Weight Loss. I'm Russell Clark, Nurse Practitioner. Today, we're exploring Metabolic Reset with Dual GIP/GLP-1 Agonists: Practical Protocol for Midlife PCOS Patients. ... Before we get into the details, let's set a steady pace — clear language, real physiology, and findings that hold up under scrutiny. ... We'll touch on Tirzepatide Cycling, PCOS Metabolic Reset, HOMA-IR Tracking — especially as they apply to real people over forty. ... Let's start with introduction. ... Midlife women with PCOS often battle stubborn insulin resistance, visceral fat accumulation, irregular cycles, and frustrating weight plateaus. Dual GIP/GLP-1 agonists like tirzepatide offer a powerful metabolic reset by mimicking natural gut hormones to improve insulin sensitivity, reduce appetite, and target visceral adiposity. When paired with The Clark Protocol’s structured 6-week-on, 4-week-off cycling, this approach creates sustainable change rather than lifelong medication dependence. This practical guide synthesizes Calories In Calories Out fundamentals, biomarker tracking, gut repair, and lifestyle integration into a 30-week framework tailored for midlife PCOS management. ... Listen at CFP Weight Loss — clinical guide with Russell Clark, FNP-C. Read more: https://blog.cfpweightloss.com/metabolic-reset-and-dual-gip-glp-1-agonists-class-practical-protocol-steps-for-m-usagcn