This podcast conversation discusses the FDA approval of a new drug called Cobenfi for the treatment of schizophrenia, inspired by the German blog post: A New Approach to Schizophrenia Treatment: Cobenfi and the Rediscovery of Xanomelin, Blog #124 from Klaus Rudolf’s blog. Cobenfi is a combination of two existing medications, Zenomalin and Trospium. Zenomalin, initially developed in the 1990s to treat Alzheimer’s disease, was later discontinued due to side effects. Trospium, a drug commonly used for overactive bladder, was added to Cobenfi to counteract these side effects. The podcast covers how the drug works and its potential impact on treating schizophrenia. It also addresses the drug’s cost and availability. Additionally, the participants underscore the ethical implications of Cobenfi and emphasize the importance of examining the effects of this medication on schizophrenia and other neurological disorders.