Currently, the conjugation strategies used to join payload and a guidance chimera are similar to those used in developing full-length Ab-based immuno-conjugates. To develop a ChimtoximAb, the designer often utilizes the exogenous effector moieties and antibody fragment molecules to create the conjugate. ChimtoximAb development is trending in terms of discovering the next-generation, functionally enhanced immuno-therapeutics with fragment antibodies as well as Fc-fusion proteins.