The sermon centers on establishing the resurrection of Christ as a cornerstone of faith, drawing heavily from Psalm 16 as interpreted by David and later affirmed by Peter. It emphasizes that the prophetic nature of David's words, particularly concerning a descendant who would not be abandoned in the grave nor experience corruption, serves as powerful evidence for Christ's resurrection. The message underscores the significance of prophecy, eyewitness testimony, and the sending of the Holy Spirit as irrefutable proof of Christ's victory over death, offering believers hope for eternal life and a future reign with Him.