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Clearing the Traffic for Treating Major Depression
On this week's episode, we show an increased drive into vagus nerve stimulation clinical research. This FDA-approved therapy for major depressive disorder (MDD) is undergoing further trials in an effort to get it approved by big insurance carriers like Medicaid.
- Hasin DS, Sarvet AL, Meyers JL, et al. Epidemiology of adult DSM-5 major depressive disorder and its specifiers in the United States. JAMA Psychiatry. 2018;75(4):336–346. doi:10.1001/jamapsychiatry.2017.4602
- Substance Abuse and Mental Health Services Administration. DSM-5 Changes: Implications for child serious emotional disturbance [Internet]. Substance Abuse and Mental Health Services Administration. 2016. Accessed December 22, 2025. https://www.ncbi.nlm.nih.gov/books/NBK519712/table/ch3.t5
- Luing H, Schramm E. Modern psychiatry offers new hope for depression. MedEvidence!. 2025. Accessed December 22, 2025.
https://medevidence.com/modern-psychiatry-offers-new-hope-for-depression - Noetel M, Sanders T, Gallardo-Gómez D, Taylor P, del Pozo Cruz B, Van Den Hoek D, Smith JJ, Mahoney J, Spathis J, Moresi M, Pagano R. Effect of exercise for depression: systematic review and network meta-analysis of randomised controlled trials. BMJ. 2024 Feb 14;384. https://pubmed.ncbi.nlm.nih.gov/38355154/
- US Food and Drug Administration. Premarket approval (PMA) for VNS Therapy system. US Department of Health & Human Services. Accessed December 22, 2025. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpma/pma.cfm?id=p970003s050
- LivaNova US. SYMMETRY for difficult to treat depression. Accessed December 22, 2025. https://www.livanova.com/depression/en-us/what-is-symmetry
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By MedEvidence ArticlesOn this week's episode, we show an increased drive into vagus nerve stimulation clinical research. This FDA-approved therapy for major depressive disorder (MDD) is undergoing further trials in an effort to get it approved by big insurance carriers like Medicaid.
- Hasin DS, Sarvet AL, Meyers JL, et al. Epidemiology of adult DSM-5 major depressive disorder and its specifiers in the United States. JAMA Psychiatry. 2018;75(4):336–346. doi:10.1001/jamapsychiatry.2017.4602
- Substance Abuse and Mental Health Services Administration. DSM-5 Changes: Implications for child serious emotional disturbance [Internet]. Substance Abuse and Mental Health Services Administration. 2016. Accessed December 22, 2025. https://www.ncbi.nlm.nih.gov/books/NBK519712/table/ch3.t5
- Luing H, Schramm E. Modern psychiatry offers new hope for depression. MedEvidence!. 2025. Accessed December 22, 2025.
https://medevidence.com/modern-psychiatry-offers-new-hope-for-depression - Noetel M, Sanders T, Gallardo-Gómez D, Taylor P, del Pozo Cruz B, Van Den Hoek D, Smith JJ, Mahoney J, Spathis J, Moresi M, Pagano R. Effect of exercise for depression: systematic review and network meta-analysis of randomised controlled trials. BMJ. 2024 Feb 14;384. https://pubmed.ncbi.nlm.nih.gov/38355154/
- US Food and Drug Administration. Premarket approval (PMA) for VNS Therapy system. US Department of Health & Human Services. Accessed December 22, 2025. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpma/pma.cfm?id=p970003s050
- LivaNova US. SYMMETRY for difficult to treat depression. Accessed December 22, 2025. https://www.livanova.com/depression/en-us/what-is-symmetry