In this episode, Ian details a nice paper by McLaughlin, Hartjes, and Freeman who tracked 20 of their own Neuro ICU patients who were receiving the standard hour-by-hour neurological examinations after admission to the Neuro ICU to find out whether sleep deprivation might be related to the potential for seeing increased neurological deterioration or ICU delirium during their tenure on the unit. The proposal is that this effect, if observed, might be mediated or moderated by sleep deprivation. This was a single-arm, prospective, natural history cohort design, designed to look at their pt population prevelance of neurological decline or delirium, and as such is purely descriptive in nature. But these authors did a commendable job in detailing the descriptives and frequencies of their sample, and raise fascinating and important questions which are sure to lay the groundwork for an important experimental literature to follow.