By Nathan Teuscher
5
1818 ratings
The podcast currently has 37 episodes available.
In this episode I talk about dose proportionality, which is a surrogate for determining if we have linear clearance across a range of dose levels. I discuss 3 different methods that people use to determine dose proportionality along with a recommendation to use the power model method.
Links discussed in the show:
This episode is a discussion of covariate search methods. I give definitions of covariates and predictors, and then I describe 3 different covariate search methods. For each method I describe the pros and cons associated with each one, including bias and time limitations.
Links discussed in the show:
Copyright Teuscher Solutions LLC
All Rights Reserved
In this episode I describe stimulatory indirect response PK-PD models. I describe how they work, how to set up the dataset for NONMEM, and how to code the model in NONMEM. This is the last of 4 episodes on different PK-PD models.
Links discussed in the show:
Copyright Teuscher Solutions LLC
All Rights Reserved
In this episode I describe inhibitory indirect response PK-PD models. I describe how they work, how to set up the dataset for NONMEM, and how to code the model in NONMEM. This is the third of 4 episodes on different PK-PD models.
Links discussed in the show:
Copyright Teuscher Solutions LLC
All Rights Reserved
In this episode I describe effect compartment PK-PD models. I describe how they work, a method of creating exploratory plots, how to set up the dataset for NONMEM, and how to code the model in NONMEM. This is the 2nd of 4 episodes on different PK-PD models.
Links discussed in the show:
Copyright Teuscher Solutions LLC
All Rights Reserved
In this episode I describe direct effect PK-PD models. I describe how they work, a method of creating exploratory plots to identify direct effect models, how to set up the dataset for NONMEM, and how to code the model in NONMEM. This is the first of 4 episodes on different PK-PD models.
Links discussed in the show:
Copyright Teuscher Solutions LLC
All Rights Reserved
In this episode I discuss different methods of presenting pharmacokinetic and pharmacometrics results. I spoke about using PowerPoint and R Markdown derived HTML files. While I prefer HTML files in nearly all cases, I appreciate that sometimes PowerPoint format is required by some companies. I included multiple suggestions for both PowerPoint and HTML files that can help make the information presentation more effective.
Links discussed in the show:
Copyright Teuscher Solutions LLC
All Rights Reserved
This episode covers the terminal elimination rate constant calculated using non-compartmental analysis techniques. I reviewed how the rate constant is used to estimate half-life and extrapolate AUC to infinity, reviewed the methods for calculating the terminal rate constant value, and some important points about sample selection. Finally, I gave my reasons that we should ultimately stop talking about this and fretting over the method of calculation. Instead, let’s design better PK experiments with more optimal sampling to capture decline of the drugs we are studying.
Links discussed in the show:
Copyright Teuscher Solutions LLC
All Rights Reserved
This episode covered parallelization in modeling analyses. I spoke about across model parallelization and within model parallelization. I recommended some approaches for choosing how many cores to use in parallelization and also discussed different modeling computer systems you can use.
Links discussed in the show:
Copyright Teuscher Solutions LLC
All Rights Reserved
Today I covered 2 different topics. First, I spoke about residual error models when modeling. I discussed additive, proportional, and power models. I also reviewed combined models and when they can be helpful. Then I spoke about modeling report submission packages. I explained what I put in those packages, how they are used, and some potential changes coming in the future.
Links discussed in the show:
Copyright Teuscher Solutions LLC
All Rights Reserved
The podcast currently has 37 episodes available.
1,721 Listeners
90,454 Listeners
37,886 Listeners
30,738 Listeners
298 Listeners
43,197 Listeners
1,590 Listeners
111,405 Listeners
85 Listeners
9,479 Listeners
305 Listeners
15,497 Listeners
24,049 Listeners
25 Listeners
320 Listeners