Dr. Dave L. Dixon discusses the benefits of clinical practice guidelines (CPGs), reviews the guideline development process, discusses limitations in this process and in applying CPGs to patient care, identifies opportunities for improvement, provides considerations for educating learners and other health care professionals about CPGs, and examines the role of pharmacists in CPG development, dissemination, and implementation. Access the full-text manuscript for free at: https://accpjournals.onlinelibrary.wiley.com/doi/10.1002/jac5.1743.