Dr. Jason Yerke summarizes current evidence from clinical trials and comparative studies evaluating terlipressin continuous infusion versus intermittent bolus dosing strategies, with a focus on efficacy, safety, and operational considerations. Read the full-text manuscript: https://accpjournals.onlinelibrary.wiley.com/doi/10.1002/phar.70084.

In this episode of the JACCP Podcast, Drs. Alex Kim, Michael Behal, and Heather Blue discuss with host Stuart T. Haines how pharmacists are portrayed, or often not portrayed, in mass media like TV and movies. A recent study documented that between 2013 and 2023, pharmacist characters (47%) were negatively portrayed, and the majority (59%) had no significant impact on the plot. Furthermore, medical dramas often omit pharmacists from their cast of characters, despite their critical role in real-world settings. The guests argue that increased advocacy is needed to better inform the public and media about the diverse clinical roles that pharmacists play and the valuable contributions they make to patient care.

The mortality and economic burden of drug induced acute kidney injury are substantial, emphasizing the need for prevention and optimal treatment. Dr. Sandra Kane-Gill provides perspective on novel kidney biomarkers and how they offer a missing piece of the assessment for early detection and management of DI-AKI. Read the full manuscript at: https://accpjournals.onlinelibrary.wiley.com/doi/full/10.1002/phar.70071

Despite evidence that adverse drug events manifest with greater severity in pediatric populations than in adults, fewer than 50% of drugs have been systematically studied for pediatric use. The lack of robust drug safety data may result in suboptimal or harmful treatment strategies. Saurabh Rahurkar and Pallavi Jonnalagadda share their team's efforts to address this issue. This podcast and article specifically address the use of benzonatate in pediatric patients. Read the full text open access manuscript at: https://accpjournals.onlinelibrary.wiley.com/doi/10.1002/phar.70061.

Turning Curiosity into Research Ideas, Questions, and Aims

This episode of the JACCP Podcast, featuring Drs. Michael Ernst and Gary Cochran, breaks down the often-intimidating process of generating and refining research ideas. The experts stress that good research stems from curiosity and deep background knowledge. They recommend using a structured format, like the PICOT framework, to translate broad concepts into precise, researchable questions and testable aims. The discussion concludes with essential career advice: seeking out mentors, leveraging collaborative networks, and being purposeful in professional development. Read the full manuscript.

Key Issues Discussed

• Sources of Research Inspiration: Drawing ideas from clinical practice, intellectual curiosity, lectures/grand rounds, journal clubs, and informal "coffee rounds."
• The Importance of Background Work: Developing a deep knowledge of the literature to ensure the research idea is novel and adds value.
• Structuring the Research Question: Using frameworks (e.g., PICOT) to clearly define the population, intervention, comparator, and outcome.
• Refining Aims and Hypothesis: Keeping the number of aims simple and limited and understanding that a research question goes through an iterative refinement process.
• Advice for Junior Investigators: Identifying successful mentors, utilizing developmental programs (like ACCP’s FIT and MERIT), and building collaborative networks.

Join Drs. William Petros and Bob Powell as they share advice on pursuing a sustainable career in the pharmaceutical industry. Hosted by Dr. Robbie Parker, they reflect on their professional journeys and the changes that have occurred, especially related to the depth of scientific and researchskill training. This podcast and article are a call to action to provide direction and support for pharmacists seeking successful careers in Pharma. Read the full text review at: https://accpjournals.onlinelibrary.wiley.com/doi/10.1002/jac5.70105.

Dr. Arden Barry shares his team's findings from their large population database when evaluating the effect of exposure to P2Y12 inhibitors, versus no exposure, on the occurrence of major adverse cardiovascular events. The results support the use of P2Y12 inhibitors (primarily clopidogrel), in addition to other standard cardiovascular preventive therapy, in patients who undergo CABG surgery, but take a listen for all the details. Access the OPEN ACCESS manuscript here: https://accpjournals.onlinelibrary.wiley.com/doi/10.1002/phar.70047

In this episode, Stuart Haines, JACCP Editor-in-Chief, interviews Dr. Andrea Sikora, Dr. Brian Murray, and Dr. Susan Smith about their recently published consensus recommendations for integrating critical care pharmacists into intensive care unit (ICU) teams which was endorsed by ACCP as well as the American Association of Critical-Care Nurses, American Society of Health-System Pharmacists, Institute of Safe Medication Practices, and the Society of Critical Care Medicine.  The paper was published in the September 2025 issue of JACCP and is available open access. The document addresses the "unmet need" of operationalizing the pharmacist's role, as evidence suggests that many ICUs still lack a critical care pharmacist. The recommendations go beyond simply advocating for pharmacists; they provide a blueprint for hospitals to optimize pharmacist services, including direct and indirect patient care activities. The paper and its supplementary materials, which include an institutional assessment checklist, can be used to improve the quality of patient care.

Dr. Nevena Radonjic, psychiatrist and scientist at SUNY Upstate Medical University, shares insight on optimizing the mental health of pregnant and breastfeeding women. She expands upon this case published in Pharmacotherapy of managing ADHD in a breastfeeding mother. Read the full case report at: https://accpjournals.onlinelibrary.wiley.com/doi/10.1002/phar.70035

Join Stuart T. Haines, editor-in-chief of JACCP, as he, along with Drs. Joseph DiPiro, Leigh Ann Ross, and George McKinnon, unpack the National Academy of Medicine (NAM) workshop entitled Innovations in Pharmacy Training and Practice to Advance Patient Care. The episode explores the critical issuescurrently weighing on the pharmacy profession. Yet, it also celebrates the remarkable progress made in pharmacy, particularly its evolution towards patient-centered care over the past 30 years. The guests discuss forward-thinking programs and ideas that resonated at the conference,identifying areas for future investment and collective action.