In this episode of the Pharmacotherapy Podcast, host Dr. Lindsay DeVane speaks with Dr. William Baker and Dr. Alexandre Chan, guest editors of a themed issue on artificial intelligence (AI) in pharmacotherapy. The discussion explores how AI—particularly machine learning and large language models—isbeing used to predict drug response, improve safety, and streamline research and clinical workflows across diverse therapeutic areas. The guests address common concerns about trust, transparency, and clinician autonomy, emphasizingAI’s role as a supportive “copilot” rather than a replacement for clinical judgment. They also highlight current gaps and future opportunities, including pharmacogenomics, imaging data, and patient-reported outcomes, and offer practical advice for trainees and researchers seeking to build AI literacy through a combination of conceptual understanding, short courses, andcollaborative learning. Read the themed issue at: https://accpjournals.onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)1875-9114.Enhancing-Pharmacotherapy-Through-AI