JACCP associate editor and host, Erica Ernst, interviews Drs. Wendy St. Peter and Barbara Zarowitz discuss adopting race-free estimated GFR (CKD-EPI) for medication-related kidney function assessment in older adults and other patient populations, as well as moving away from the Cockcroft–Gault equation. The discussion highlights deficiencies and variabilityin Cockcroft–Gault use, emerging studies where BSA-adjusted eGFR better predicts drug clearance, barriers to cystatin C access and Medicare coverage, and the need for further research, electronic health record integration, and advocacy across organizations. Read the original article and series of letters published in JACCP.