CME

A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR.

Tosco A, De Gregorio F, Esposito S, De Stefano D, Sana I, Ferrari E, Sepe A, Salvadori L, Buonpensiero P, Di Pasqua A, Grassia R, Leone CA,Guido S, De Rosa G, Lusa S, Bona G, Stoll G, Maiuri MC, Mehta A, Kroemer G, Maiuri L, Raia V.

Cell Death Differ. 2016 Aug;23(8):1380-93. doi: 10.1038/cdd.2016.22. Epub 2016 Apr 1.

Abstract
We previously reported that the combination of two safe proteostasis regulators, cysteamine andepigallocatechin gallate (EGCG), can be used to improve deficient expression of the cystic fibrosistransmembrane conductance regulator (CFTR) in patients homozygous for the CFTR Phe508del mutation. Here we provide the proof-of-concept that this combination treatment restored CFTR function and reduced lung inflammation (P<0.001) in Phe508del/Phe508del or Phe508del/null-Cftr (but not in Cftr-null mice), provided that such mice were autophagy-competent. Primary nasal cells from patients bearing different class II CFTR mutations, either in homozygous or compound heterozygous form, responded to the treatment in vitro. We assessed individual responses to cysteamine plus EGCG in a single-centre, open-label phase-2 trial. The combination treatment decreased sweat chloride from baseline, increased both CFTR …

Host: Patrice L Basanta-Henry, MD, MHSc, FACOG

Egg freezing, or oocyte cryopreservation, can be a major relief for women who wish to preserve their fertility, allowing patients to wait for the “right time.” What are the latest advances in technology and protocol for this procedure, and who are the right patients? Host Dr. Patrice Basanta Henry welcomes guest expert Dr Kenan Omurtag to address these and other questions. Dr. Omurtag is Assistant Professor of the Division of Reproductive Endocrinology and Infertility at Washington University School of Medicine in St Louis, Missouri.

Host: Renée Simone Yolanda Allen, MD, MHSc., FACOG

Host Dr. Renee Allen welcomes Dr. Victoria Green, renowned breast cancer researcher and OB/GYN clinician. Dr. Green is an Associate Professor in the Department of Gynecology & Obstetrics at Emory University School of Medicine. She will review USPSTF recommendations of biennial mammograms compared to ACOG's recommendations, as well as differences in how we define 'breast awareness' versus breast self-examination. Join the discussion!

Host: Jennifer Caudle, DO

Guest: Renée Simone Yolanda Allen, MD, MHSc., FACOG

Host Dr. Jennifer Caudle welcomes Dr. Renee S. Allen, Board certified OB/GYN and hospitalist, Fellow of ACOG, and Masters of Health Sciences from Atlanta, Georgia. Dr. Allen shares her expertise as an OB/GYN hospitalist, the growing support from ACOG in this new arena, and the goals of an emerging subspecialty.

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Studies in the field of anthropology have shown that having a healthy grandmother plays a critically positive role in family cohesion. But the wholistic, personalized health needs of women in their elder years are not always recognized. This care disparity is all the more prominent in general OB/GYN practice, but thanks to the work of a select few, the trends may be about to change.

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Host: Michael Krychman, MD

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Host: Michael Krychman, MD

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Host: Michael Krychman, MD

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Host: Michael Krychman, MD

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Host: Michael Krychman, MD

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