CME/CE

This online educational activity reviews the scientific rationale for B7-H3 as a therapeutic target in extensive-stage small cell lung cancer (ES-SCLC). Tune in for recent clinical trial data on B7-H3–directed antibody-drug conjugates in ES-SCLC, including key efficacy and safety outcomes in pretreated populations. Learners will gain practical guidance on identifying appropriate candidates for these therapies based on trial eligibility and real-world considerations. Emphasis is placed on interprofessional management of treatment-related adverse events to elevate patient safety and continuity of care.

Contemporary trial data and global registries consistently show that ambulatory patients with heart failure with reduced ejection fraction (HFrEF) who have not experienced a recent worsening event still carry residual risk of cardiovascular death and heart failure hospitalizations. These annual rates have been estimated to exceed 10%–20%, despite adherence to quadruple guideline-directed medical therapy (GDMT) and device support. This paradox of clinical stability on the surface, yet significant residual risk underneath, creates a critical blind spot in the management of chronic HFrEF. Recent data show that the addition of soluble guanylate cyclase (sGC) stimulators provides significant reductions in CV death and all-cause mortality, particularly in individuals with moderately elevated NT-proBNP (≤6,000 pg/mL). These findings are especially important because this population is far more common in routine cardiology practice and has historically been overlooked in discussions of additional therapy. Tune in to explore a case to better understand which patients can derive the most benefit from added therapy.

On-demand webcast featuring expert-informed best practices for diagnosing and managing patients with systemic mastocytosis (SM) as well as the latest data on new and emerging SM therapies.

Watch this webcast exploring the evolving landscape of early Alzheimer’s disease (AD) detection and treatment and highlighting the role of cognitive screening, fluid biomarkers, and emerging therapies. Gain expert insights on recent data from CTAD 2025, including blood-based diagnostics, lifestyle intervention trials, antiamyloid antibody strategies, and the disappointing results from semaglutide’s phase III trials.

In this case-based discussion, Dr. David Chin Yee presents his challenges and outcomes when managing a patient with diabetic macular edema who initially declined treatment due to language limitations, cultural beliefs, and mistrust of medical interventions. The case highlights the implementation of culturally sensitive strategies and underscores the value of cultural competence and patient-centered communication in overcoming barriers to care.

In this clinical discussion, Dr. Deepak Sambhara presents a case of a working-age man with severe non-proliferative diabetic retinopathy and diabetic macular edema. He details the diagnostic process using OCT and NIR imaging and explains how he engaged the patient in his treatment journey. Patient communication strategies are emphasized, as is a collaborative approach to address mistrust and enhance adherence. The case underscores the importance of individualized care and communication in retinal disease outcomes.

In this case-based presentation, Dr. Esther Lee Kim reviews a young patient with long-standing type 2 diabetes who presented with bilateral vision loss and was initially referred for possible retinal vein occlusion. The case underscores how demographic factors can inform the risk of rapid disease progression, even in the setting of a relatively controlled HbA1c. Dr. Kim reviews longitudinal outcomes and offers clinical pearls emphasizing the importance of timely referral, frequent monitoring, and use of ancillary imaging to guide risk stratification and management in high-risk patients.

In this didactic case presentation, Dr. David Eichenbaum discusses an 88-year-old patient with non-central geographic atrophy who received inappropriate bevacizumab treatment due to uncoordinated care after relocating seasonally. The case illustrates challenges that can arise in managing retinal disease across geographically distant sites. Dr. Eichenbaum emphasizes opportunities for improved referral handoffs, patient education, and system-based solutions to ensure continuity of evidence-based treatment.

This activity explores treatment sequencing strategies for chronic lymphocytic leukemia (CLL) following frontline therapy failure based on prior therapies, mechanisms of resistance, and minimal residual disease status. Dr. Jennifer Brown discusses how distinguishing between resistance and intolerance to BTK and BCL2 inhibitors informs second-line treatment decisions. The conversation highlights the role of measurable residual disease (MRD) in guiding therapy duration, biomarker reassessment, and shared decision-making based on patient preferences and clinical risk factors.

Dr. John Byrd discusses current and emerging strategies for managing double-class-refractory chronic lymphocytic leukemia (CLL) in community settings. He emphasizes the importance of distinguishing resistance from intolerance to BTK inhibitors through clinical history and molecular testing. Data from the BRUIN trial support the use of pirtobrutinib in select patients, while newer agents, including BTK degraders and bispecific antibodies, offer promising potential. Collaboration with CLL specialists is encouraged to guide therapy sequencing and access advanced treatments such as CAR T-cell therapy.