Despite major advances in prophylaxis and supportive care, hemophilia continues to disrupt daily life, limit function, and compromise long-term well-being for many patients. Joint bleeding, subclinical bleeding, and progressive arthropathy remain important concerns, even in the modern treatment era, with ongoing impacts on pain, mobility, and health-related quality of life. Clinicians must keep pace with shifting treatment strategies, including updated factor VIII (FVIII) target levels from recent guidelines to mediate bleeding protection and the growing role of rebalancing agents. To deliver optimal care, healthcare professionals need a clearer understanding of how to preserve joint health across the lifespan, apply evolving treatment targets judiciously, and select and integrate therapies in ways that reflect the latest clinical evidence, patient priorities, and treatment burden. This activity addresses these needs through expert-led discussions focused on long-term joint outcomes, FVIII-targeted treatment strategies, and the practical clinical integration of rebalancing agents.