The sermon expounds on Colossians 3:1-17 to define true holiness as flowing exclusively from union with Christ rather than human effort or legalistic rules. It emphasizes that believers must fix their minds on the things above, recognizing their death and resurrection with Jesus as the foundation for spiritual life. The preacher outlines a process of mortification, urging Christians to identify sin at its root and bring it to the cross for forgiveness and power. Simultaneously, the message calls for vivification, where believers put on the character of Christ through virtues like compassion, humility, and love. Ultimately, every action is to be done in the name of the Lord Jesus, relying entirely on His strength and grace for daily obedience.