Join Dr. Guy Caldwell, Distinguished Research Professor at the University of Alabama, for a riveting and urgent conversation that goes beyond the lab bench to the heart of America’s biomedical research crisis. In this episode, Dr. Caldwell—an internationally recognized leader in neurodegenerative disease research—shares the real-world impact of NIH funding freezes, budget cuts, and policy gridlock on labs, promising young scientists, and the future of life-changing discoveries

Hear compelling stories from both the "Worm Shack" lab and classrooms filled with top science students: top-ranked research grants on Alzheimer’s and Parkinson’s now going unfunded, student opportunities being rescinded, and lab work grinding to a halt due to uncertainty and inconsistent support. Dr. Caldwell discusses the personal sacrifices needed to keep research and student training alive, the hidden infrastructure supporting breakthroughs, and the transformative power of investing in the next generation. Discover why basic and translational research are in jeopardy, how rare disease investigations can yield major insights, and what must change for the U.S. to remain a global science leader.

This in-depth discussion is essential for anyone concerned about public health, America’s future competitiveness, and the invaluable role of federal science funding. Explore what’s truly at stake—from lab experiments to lawmakers’ decisions—and learn how viewers can add their voices to support urgent, sustained investment in research that touches every family.

Join us for a fascinating conversation with Dr. Chad Pozarycki, PhD in analytical chemistry and astrobiology, as we dive into the cutting-edge science behind searching for life beyond Earth. In this episode, we explore groundbreaking research on how biosignature molecules—such as amino acids and ATP—can accumulate and persist in extreme, hypersaline brine environments analogous to those found on Mars, Europa, and other planets.Dr. Pozarycki explains the unique analytical challenges of working with highly salty samples, discusses innovative techniques like capillary electrophoresis and high-resolution mass spectrometry, and offers key advice for scientists developing the next generation of space-ready instruments. If you’re curious about how planetary scientists actually analyze samples from Mars or icy moons, or are interested in the intersection of analytical chemistry, planetary exploration, and astrobiology, this episode is for you!🔬 Topics covered:- Analytical methods for detecting biomolecules in salt-rich planetary environments- Overcoming salt-interference in chromatography and mass spectrometry- Method validation in extreme conditions- Adapting scientific instruments for use on Mars rovers and Europa landers- Career and practical advice for aspiring analytical chemists and astrobiologistsDon’t miss Dr. Pozarycki’s insights on the next frontiers for miniaturized analytical instruments and what it takes to prepare for future space missions.Listen now to discover how planetary analog research on Earth paves the way for discovering life elsewhere in our solar system!#Astrobiology #AnalyticalChemistry #SpaceExploration #PlanetaryScience #Chromatography #MassSpectrometry #Biosignatures

🧪 Transform Your Understanding of Modern Chromatography & AI!

Join us for an eye-opening conversation with Professor Dwight Stoll from Gustavus Adolphus College as he reveals how his team is revolutionizing liquid chromatography through high-throughput data collection and machine learning. With over 43,000 retention measurements and groundbreaking research spanning three major publications, Prof. Stoll is pioneering the future of analytical chemistry.🔬 What You'll Learn:- How short columns (5mm vs 100mm) dramatically increase measurement throughput while maintaining accuracy- The evolution from HSM1 to HSM3 models and their predictive capabilities - Why selectivity ratios are more stable than absolute retention factors- The "Manhattan Project of Chromatography" - building massive retention databases- Key challenges: column drift, mobile phase standardization, and precision trade-offs- Career advice for researchers at the intersection of chromatography and data science📊 Key Highlights:- 43,329 total retention measurements across 13 stationary phases- Revolutionary "feed injection" method for high-throughput analysis- Improved isomer selectivity predictions - crucial for pharmaceutical analysis- The holy grail: predicting retention from molecular structures🎯 Perfect For:- Analytical chemists and chromatographers- Data scientists interested in chemistry applications- Graduate students and researchers- Pharmaceutical industry professionals- Anyone curious about AI applications in science🔗 Connect with Prof. Stoll:- Gustavus Adolphus College Chemistry Department- Research focused on liquid chromatography and 2D-LC#Chromatography #MachineLearning #AnalyticalChemistry #AI #DataScience #Research #HPLC #Pharmaceutical #Chemistry #ScienceThis interview showcases cutting-edge research that's transforming how we approach method development in liquid chromatography. Don't miss this glimpse into the future of analytical chemistry!

Join David Oliva on the Concentrating on Chromatography podcast as he interviews Edward Faden, Vice President and co-owner of MAC-MOD Analytical, a leading provider of chromatography solutions since 1986. In this insightful discussion, Edward shares the history and expertise of MAC-MOD, based in Chadds Ford, Pennsylvania, and dives deep into the critical challenges of analyzing PFAS (per- and polyfluoroalkyl substances), often called "forever chemicals."Key topics include:- The pervasive nature of PFAS contamination in both environmental and laboratory settings.- Surprising sources of PFAS contamination identified in standard lab setups, from gas line tubing to everyday consumables.- The essential role of the PFAS Delay Column in ensuring accurate analysis by minimizing background interference.- Best practices for labs starting PFAS analysis to reduce contamination risks from day one.- Exciting developments in rapid sample pre-screening methods to prevent cross-contamination.Edward also discusses why PFAS are so widespread—used in products like non-stick cookware and waterproof clothing since the 1940s—and the ongoing struggle to manage their environmental persistence. Whether you're a chemist, environmental scientist, or simply curious about the impact of forever chemicals, this conversation offers valuable insights into cutting-edge analytical solutions.Don't miss out on learning about MAC-MOD's innovative approaches and future plans for PFAS analysis. Subscribe for more expert interviews and chromatography content!#Chromatography #PFAS #ForeverChemicals #EnvironmentalScience #LabAnalysis

Join us for an in-depth conversation with Dr. Eamonn Clark, postdoctoral researcher at the University of Hawaii,  Mānoa and the Water Resources Research Center, as he shares his journey in water research and laboratory innovation.In this episode:- Dr. Clark introduces his work on water treatment and disinfection byproducts, including research following the Red Hill fuel spill in Oahu.- A behind-the-scenes look at the development of a home-built nitrogen blowdown evaporator—why it was needed, how it was designed, and who can benefit from building their own lab equipment.- Discussion of workflows for PFAS analysis, the importance of accessible analytical tools, and the impact of DIY solutions in low-resource settings.- Insights into other homemade lab instruments, the role of 3D printing and PCB design, and the value of community science in water quality monitoring.- Reflections on the broader impact of water research, community engagement, and the importance of making science accessible to all.Key topics covered:- Water Resources Research Center and its mission- Analytical methods for PFAS and disinfection byproducts- Step-by-step overview of building a nitrogen evaporator- Who should consider DIY lab equipment- The future of homemade scientific tools and citizen science- Community outreach and the real-world impact of water researchWhether you’re a scientist, student, or simply curious about how research labs innovate on a budget, this episode offers practical advice and inspiration for building your own scientific equipment and making a difference in your community.Check out for links to Dr. Clark’s technical note and additional resources on DIY lab equipment and water research:- https://pubs.rsc.org/en/content/articlelanding/2025/ay/d4ay02118e/unauth- https://pubs.rsc.org/en/journals/articlecollectionlanding?sercode=ay&themeid=9bc2db53-354c-4a55-84eb-93fcae875044- https://blog.organomation.com/blog/inaugural-homemade-evaporator-contest-results-the-peak-of-ingenuity

Dr. Haleigh Boswell, Research Chemist at Chevron, joins the Concentrating on Chromatography podcast to discuss her fascinating career journey and cutting-edge analytical work in the energy industry. In this in-depth interview, Dr. Boswell shares:🔬 Technical Insights:- How two-dimensional gas chromatography (GCxGC) differs from traditional GC and why it's revolutionary for complex sample analysis- Applications of GCxGC in analyzing hydrocarbon and renewable matrices- Detector selection strategies (FID, SCD, NCD, TOF-MS) for different analytical challenges- Sample preparation considerations for complex energy industry matrices🎯 Industry Applications:- Real-world problem-solving in refinery operations and catalyst development- Non-targeted analysis for trace contaminants in renewable feedstocks- Process optimization and quality control in energy production- Safety considerations and instrument maintenance in industrial settings📈 Career Journey:- Transition from forensic science undergraduate studies to analytical chemistry- Moving from academia to industry: challenges and adaptations- The importance of networking in scientific careers- Advice for graduate students considering industry positions🏢 Behind the Scenes at Chevron:- Day-to-day responsibilities as a subject matter expert (SME)- Collaborative work across multiple R&D teams- Modernizing analytical instrumentation in a legacy company- Balancing innovation with business needs and safety requirementsThis episode provides valuable insights for analytical chemists, graduate students, and anyone interested in the practical applications of advanced chromatography techniques in industrial settings[#Chromatography #AnalyticalChemistry #EnergyIndustry #GCxGC #CareerAdvice #ChemistryPodcast

In this episode of Concentrating on Chromatography, host David Oliva interviews Dr. Petr Vozka, Assistant Professor at California State University, Los Angeles, about his journey establishing the Complex Chemical Composition Analysis Lab (C³AL).Dr. Vozka shares how he built his research facility during the pandemic, focusing on creating opportunities for first-generation and underrepresented undergraduate students. Learn about the groundbreaking LECO-C³AL partnership that provides students with hands-on experience using advanced comprehensive two-dimensional gas chromatography (GC×GC) instrumentation.The conversation explores:- Building a cutting-edge analytical chemistry lab during challenging circumstances- Creating research opportunities for underrepresented undergraduate students- The innovative fingerprint aging research in collaboration with the Hertzberg-Davis Forensic Science Center- How multidimensional chromatography enables detection of thousands of compounds in complex mixtures- The workflow for analyzing fingerprint samples using GC×GC-TOFMS- The advantages of nitrogen generators in laboratory settingsDr. Vozka also discusses the upcoming 17th Multidimensional Chromatography Workshop (MDCW), a FREE conference taking place January 13-15, 2026, in Williamsburg, VA, bringing together experts in multidimensional separation techniques.Visit Dr. Vozka's lab website: https://www.calstatela.edu/research/c3alLearn more about MDCW: https://www.multidimensionalchromatography.com/#Chromatography #GCGC #ForensicScience #AnalyticalChemistry #Fingerprints #MDCW #CalStateLA

Eugene Oga, a PhD student in Analytical Chemistry at the University of North Dakota, joins David Oliva to discuss his innovative research on silicone sealant degradation using evolved gas analysis and thermal desorption-pyrolysis gas chromatography. With his background in materials chemistry and current focus on analytical techniques, Eugene shares insights into how these advanced methods can characterize material breakdown over time, with significant implications for the construction industry and beyond.Eugene's Background and Research FocusEugene Oga is pursuing his PhD in Analytical Chemistry at the University of North Dakota, following his Bachelor's and Master's degrees from the University of Buea in Cameroon. His academic journey began with a focus on materials chemistry before transitioning to analytical chemistry, recognizing that material properties and performance depend heavily on proper characterization.His current research employs advanced analytical techniques like evolved gas analysis and pyrolysis gas chromatography to understand how materials break down over time and identify the specific fragments produced during degradation. This work aims to provide recommendations to manufacturers about potential improvements to their processes.Understanding Structural Sealant Glazing and Its ImportanceStructural Sealant Glazing (SSG) plays a critical role in modern construction, particularly in buildings that extensively use glass and metal. Eugene explains that sealants are thick liquids used to bind different construction materials together.These sealants serve multiple important functions, including preventing air infiltration, moisture penetration, and enhancing building stability. While studies have estimated how long sealants and buildings should last, they often don't explain the actual breakdown mechanisms. Eugene's research aims to fill this gap by identifying which components are lost over time and how this degradation occurs, ultimately enabling better prediction of failure and development of solutions.Different Failure Modes and Analytical ApproachesEugene identifies several categories of sealant failure that require different analytical approaches:1. Adhesive/cohesive failures: These occur when materials don't properly bind together, often due to surface preparation issues that can be addressed through proper cleaning.2. Chemical degradation: This includes processes like UV exposure, hydrolysis, and oxidation.3. Environmental factors: Temperature fluctuations, moisture, and pollutants can contribute to degradation.4. Physical degradation: Manifesting as cracking, fatigue, and creep.While mechanical analysis can identify physical changes like cracking and strength loss, it doesn't reveal which chemical components are being lost. For all these failure modes, gas chromatography and mass spectrometry prove essential.In all of these different failure modes and causes, gas chromatography and mass spectrometry would be very important to identify the volatile degradation products and the changes that are accompanying the backbone.Innovative Methodological ApproachEugene's research employs a two-step analytical approach that modifies standard GC-MS protocols to accommodate siloxane chemistry:1. Evolved Gas Analysis (EGA-MS): This serves as a rapid screening technique to identify temperature ranges where components evolve.2. Thermal Desorption-Pyrolysis GC-MS: This follows as a verification tool, focusing on the specific temperature zones identified by EGA to perform detailed analysis of components evolving at different temperatures.This sequential approach allows for more targeted analysis and better characterization of degradation products. The method is particularly valuable because it eliminates extensive sample preparation—samples can be analyzed as received, saving significant time and reducing potential preparation errors.

In this enlightening episode of Concentrating on Chromatography, host David Oliva engages in a comprehensive discussion with Lisa Jones, Director of Higher Education Relations at I.W. Tremont Co. and active NAOSMM volunteer, alongside Jim Averso, Co-President at I.W. Tremont and producer of the LabExact brand of laboratory consumables.

The conversation explores critical aspects of laboratory supply management, including best practices for procurement in academic settings, inventory challenges, and the advantages of American-made products. Lisa shares valuable insights from her 27 years of experience at the University of Alabama, highlighting how institutional policies affect purchasing decisions and the complexities of managing laboratory stockrooms. Jim discusses how I.W. Tremont develops products based on real laboratory workflows and responds to researcher feedback.

Key topics include:

• The role of NAOSMM (National Association of Scientific Materials Managers) in connecting laboratory managers with quality suppliers

• Challenges of cylinder-based nitrogen supply versus on-demand nitrogen generation

• The importance of vendor selection criteria including quality certification, inventory availability, and customization capabilities

• How academic procurement processes vary between institutions and departments

• The value of American manufacturing and family-owned businesses in the scientific supply chain

Whether you're managing university laboratory resources, working in a research facility, or supplying the scientific community, this episode offers practical perspectives on streamlining your supply chain while maintaining research quality and addressing the unique challenges of laboratory operations.

#LabSupplies #AcademicResearch #LabManagement #NAOSMM #ScientificProcurement #ChemistryLab #LabExact

In this episode of Concentrating on Chromatography, host David Oliva interviews Jim Averso, Co-President of I.W. Tremont and manufacturer of the LabExact brand, celebrating their 45th year in business. Jim shares expert insights on the critical role of filtration in chromatography sample preparation.Discover:- Why proper filtration is essential for protecting your expensive HPLC columns- How to select the right membrane type (Nylon, PTFE, PVDF, or PES) based on your sample- Common mistakes researchers make with syringe filters and how to avoid them- The innovative TruPor membrane technology that increases loading capacity while improving flow rates- Tips for preventing membrane intrusion and back pressure issues- The new HandyPrep device that simplifies pre-filtration steps- Advanced techniques like filter stacking for improved sample preparationWhether you're working with HPLC, UHPLC, GC, or other chromatography methods, this conversation provides valuable insights to optimize your workflow and improve analytical results.Jim also discusses the Laboratory Products Association's student engagement committee, which is building bridges between academia and commercial science careers.#Chromatography #LabTechniques #SamplePreparation #HPLC #Filtration #LabExact #ScienceEducation