This episode reviews cases of steroid-induced laminitis and examines recent research and owner-reported experiences using SGLT2 inhibitors (most commonly ertugliflozin) as an off-label treatment for equine metabolic syndrome and hyperinsulinemia-associated laminitis.

An online survey of 342 owners found most horses treated with SGLT2Is showed improved quality of life and reduced pain, with many horses spared from euthanasia; common initial side effects included increased drinking and urination, weight loss, and dullness, which were often dose-dependent or resolved over time.

Key takeaways: SGLT2Is show promise as a rescue option for laminitis when combined with strict dietary management and good hoof care, but long-term safety, availability, cost, and further research remain important considerations.

Research 

https://beva.onlinelibrary.wiley.com/doi/abs/10.1111/eve.14071

https://scholar.google.com/scholar?hl=en&as_sdt=0%2C14&as_vis=1&q=sundra+et+al+2025+Horseowner&btnG=#d=gs_qabs&t=1787417730062&u=%23p%3DSFYkeG9TZt4J

Humble Hoof Podcast Episode

https://open.spotify.com/episode/4CvEegebGNduL7hNJDAlFc?si=UWRrM3TuRJuXyg0Rxx_vSA&utm_source=copy-link

This episode explores whether horses can experience headaches by examining cervical spine pain, common signs like head rubbing or altered carriage, and how musculoskeletal and nervous system issues contribute to discomfort.

Nancy reviews diagnostic options, treatment and rehabilitation strategies, and the need for improved imaging and physiotherapy to restore performance and well-being.

Research Link: https://www.mdpi.com/2076-2615/11/2/422

In this episode Nancy McLean explores a listener question about whether to remount after a fall, using Dr. Stephen Peters’ research and a review by McBride et al. to explain how equine learning, myelination, and long-term potentiation shape behavior.

Nancy explains how automaticity, basal ganglia consolidation, and dopamine-driven rewards can help overwrite fearful responses, and she shares a real-life example of calmly remounting to reinforce positive patterns.

Key takeaway: when horse and rider are uninjured, a calm remount and rewarded repetition can help redirect the horse’s neural pathways and prevent lasting fear responses.

In this episode Nancy McLean explores Dr. Stephen Peters' book Horse Brain Science, comparing human and equine brain anatomy and function. She explains brain size and cortical folding, then walks through the four main lobes (frontal, parietal, temporal, occipital), the amygdala and hippocampus, and the brainstem.

The episode connects these brain differences to horse behavior and training—why punishment fails, how pressure and removal or positive rewards work, and how understanding sensory processing, memory, and fear responses can improve ethical horsemanship.

This episode introduces equine neurobiology through the work of Dr. Stephen Peters, explaining core concepts like neurons, neurotransmitters, neuroplasticity, and how sensory processing affects learning and behavior.

It shows how applying neuroscience can reduce stress, build trust, and improve training and welfare, and previews a follow-up episode on brain anatomy.