CorConsult Rx: Evidence-Based Medicine and Pharmacy

CorConsult Rx: Evidence-Based Medicine and Pharmacy episodes:

• 04.25.2024

  Hormonal Contraception Pharmacotherapy *ACPE-Accredited*

  On this episode, we review various hormonal contraception options. We disucss the benefits and risks associated with different forms of estrogen and progestins as well as considerations when choosing a contraceptive option based on patient-specific factors. Cole and I are...

  
• 04.10.2024

  2024 AAD Acne Treatment Guidelines *ACPE-Accredited*

  On this episode, we discuss the 2024 acne treatment guidelines that was published by the American Academy of Dermatology. This new set of guidelines was intended as an update to the AAD's 2016 acne guidelines. We review the use of...

  
• 03.26.2024

  Managing Dry Eye Disease and Allergic Conjunctivitis *ACPE-Accredited*

  On this episode, we examine the management of dry eye disease and allergic conjunctivitis. It is important that pharmacists and nurses understand the appropriate use of the medications and when to seek a more thorough work-up. This session seeks to...

  
• 03.05.2024

  Healing Heartburn: An Approach to GERD Management *ACPE-Accredited*

  On this episode, we discuss the treatment options used for the managment of gastroesophageal reflux disease. We review various types of antacids, H2 blockers, and proton pump inhibitors. We also go over the long term risks associated with these meds. ...

  
• 01.25.2024

  Treatment and Prevention of Hepatitis A and B Infections *ACPE-Accredited

  On this podcast we discuss the management of both hepatitis A and B. We review some background information as well as the criteria for a diagnosis of either. We also go over vaccinations for both viruses and some of the...

  
• 01.20.2024

  High Science: The Medical Potential of THC, CBD, and Synthetics

  On this episode, we are joined by returning guest Dr. Kaleigh Steeleman. Kaleigh is currently a PGY-1 resident at Chaple Hill. She has spent some of her residency time working with functional medicine professionals. She has been particularly interested with...

  
• 01.11.2024

  Diagnosis and Management of Lupus and Related Complications *ACPE-Accredited*

  On this episode we examine systemic lupus erythematosus (SLE). Lupus is a relatively uncommon condition, but is debilitating for those who suffer from it. There are newer medications with unique mechanisms used for this disease. It is important that pharmacists...

  
• 01.02.2024

  Beyond the Beat: Exploring the 2023 A Fib Guidelines *ACPE-Accredited*

  On this episode, Cole and I review the 2023 updated atrial fibrillation guidelines. We discuss various rate-control and rythmn-control pharmacotherapy options. We also summarized the acute management vs maintenance therarpy.  Cole and I are happy to share that our listeners...

  
• 12.12.2023

  Curing Hep C: A Dive into Treatment Options *ACPE-Accredited*

  On this episode, we review the 2023 Hepatitis C Guidance that was recently published by the Infectious Diseases Society of America (IDSA) and the American Association for the Study of Liver Diseases (AASLD). We discuss the pre-treatment work-up, various treatment...

  
• 11.28.2023

  2023 New Drug Approvals *ACPE-Accredited*

  On this episode, Cole and I review some of the medications that gained U.S. FDA approval in 2023. We cover a variety of medications that treat various disease states. We focused more on outpatient medications and did not cover new...

  
• 11.14.2023

  Treatment of Acute Rhinosinusitis and Pharyngitis *ACPE-Accredited*

  On this episode, my good friend and colleague Alex Hovey, PA-C is sitting in for Cole this episode. We review the treatment of acute rhinosinusitis and pharyngitis. We mention some treatment options for symptom relief in patients with viral sinusitis...

  
• 11.02.2023

  Healing Hidden Wounds: Exploring PTSD Treatment *ACPE-Accredited*

  On this episode we review post-traumatic stress disorder (PTSD). We discuss some background information on the disease. Then, we review the various treatment options used to manage PTSD symptoms. To finish the episode, we go through Dr. David N. Osser,...

  
• 10.25.2023

  Exxua (gepirone): the newly approved antidepressant

  On this episode, we discuss the 5-HT1A receptor agonist, Exxua (gepirone). Exxua was recently FDA approved for the treatment of general depression. We review the long road this medication took to get approved. We also summarize the dosing, adverse effects,...

  
• 10.17.2023

  Classification and Management of Chronic Kidney Disease *ACPE-Accredited*

  On this episode, we review the management of chronic kidney disease. We discuss when to use iron vs erythropoietin-stimulating agents (ESAs) for a patient with anemia due to their CKD.  We also go over the management of metabolic acidosis, hyperphosphatemia,...

  
• 10.04.2023

  Navigating the Urinary Maze: BPH, OAB, and the complexities of treatment when they coexist *ACPE-Accredited*

  On this episode we discuss the management of benign prostatic hyperplasia (BPH) as well as overactive bladder (OAB). We review alpha blockers, 5-alpha-reductase inhihibitors, PDE5-inhibitors, anticholinergics, and beta 3 agonists. We close by discussing the best treatment options for patients...

  
• 09.20.2023

  Treating UTIs *ACPE-Accredited*

  On this episode, we review the treatment of both uncomplicated and complicated urinary tract infections (UTIs). We also use this episode to refresh some clinical pearls for the various antibiotics that are used when treating a UTI.  Cole and I...

  
• 09.18.2023

  High Powered Medicine Book Review

  On this episdoe, we are joined by Dr. Alex Poppen, PharmD, the author of High Powered Medicine. HPM is a book that summarizes over 150 landmark clinical trials. We discuss how Alex came up with the idea for the book...

  
• 09.11.2023

  Managing Gout *ACPE-Accredited*

  On this episode, we discuss both treating an acute gout flare and chronic management of gout. We discuss colchicine, NSAIDS, corticosteroids, canakinumab, xanthine oxidase inhibitors, uricosurics, URAT-1 inhibitor, and more.  Cole and I are happy to share that our listeners...

  
• 08.21.2023

  Managing Osteoarthritis Pain *ACPE-Accredited*

  On this episode, we review pharmacotherapy options for managing osteoarthritis pain. We focus primarily on on hand, knee, and hip OA. We cover NSAIDS, COX2 inhibitors, topical capsaicin, intra-articular corticosteroids, intra-articular hyaluronic acid, duloxetine, and more.  Cole and I are...

  
• 08.09.2023

  A Review of Weight Loss Medications *ACPE-Accredited*

  On this episode, we review the medications that are FDA approved for weight loss. We also review recent data on high dose oral semaglutide and injectable tirzepatide. We end by looking at drugs that are currently in the pipeline with...

  
• 07.31.2023

  Alteplase vs Tenecteplase for Ischemic Stroke

  On this episode, we are joined by Dr. Brian Gilbert, PharmD, BCCCP, FCCM, FNCS, to compare and contrast alteplase (tPA) versus tenecteplase (TNK-tPA) in the setting ischemic stroke. Brian is an emergency medicine clinical pharmacy specialist at Wesley Medical Center....

  
• 07.24.2023

  Managing Hypothyroidism *ACPE-Accredited*

  On this episode, we review the management of hypothyroidism. We focus on levothyroxine as the foundation for a patient treatment. We also discuss the contraversial issue of using synthetic T3 (liothyronine) as an augmentation option for certain patients. The link...

  
• 07.11.2023

  Treating Community Acquired Pneumonia *ACPE-Accredited*

  On this episode, we discuss the various treatment options for community acquired pneumonia. We compare and contrast the differences in treating a patient with and without comorbidities in the outpatient setting as well as non-severe and severe CAP in the...

  
• 06.30.2023

  Substance Use Disorder *ACPE-Accredited*

  On this episode, we discuss the management of substance use disorder. We review the pharmacotherapy/psychotherapy options for treating the abuse of alcohol, cocaine, methamphetamine, cannabis, benzodiazepines, and opioids. Make sure to check out our previous episode that covers opioid use...

  
• 06.13.2023

  Smoking Cessation *ACPE-Accredited*

  On this episode, we discuss the pharmacotherapy options available for smoking cessation. We start with some background info including pathophysiology, psychology models applicable to smoking cessation, and nicotine dependence assessments.  We review varenicline, nicotine replacement therapy in various forms, bupropion...

  
• 06.08.2023

  Patient Case: Sickle Cell Disease, HFrEF, DM2, and More

  On this episode, we go over a pharmacotherapy plan for a patient with sickle cell disease, HFrEF, DM2, dyslipidemia, hypertension, POAG, dry eye disease, constipation, GERD, and OSA. Episode 227 Patient Case Information 57-year-old male with sickle cell disease,...

  
• 05.30.2023

  A Closer Look at Managing Depression in Patients with Comorbidities *ACPE-Accredited*

  On this episode, we discuss the considerations and possible changes to a patient's general depression regimen when they have various comorbidities or other circumstances that affect their health . The comorbidities/situations that we cover include: patients with coronary artery disease,...

  
• 05.24.2023

  Preventing Recurrent C. diff Infections with Vowst

  On this episode, we discuss Vowst, the oral fecal microbiota product for preventing the recurrance of C. diff infection. We review Vowst's dosing, administration, drug-drug interactions, clinical trial data, and more.  Thanks for listening! If you want to support the...

  
• 05.15.2023

  Osteoporosis Management *ACPE-Accredited*

  On this episode, we review the various pharmacotherapy options that are used in the management of osteoporosis. We go over bisphosphonates, denosumab, parathyroid hormone analogics, and romosozumab.  Cole and I are happy to share that our listeners can claim ACPE-accredited...

  
• 05.01.2023

  Managing Acne Vulgaris *ACPE-Accredited*

  On this episode, we compare and contrast the various pharmacotherapy options used to manage acne vulgaris. We review topical retinoids, topical and oral antibiotics, androgen-receptor inhibitors, oral contraceptives, spironolactone, and oral isotretinoin. We close with a patient case to summarize...

  
• 04.21.2023

  A Review of Ulcerative Colitis *ACPE-Accredited*

  On this episode, we discuss the management of ulcerative colitis and review the various pharmacotherapy options that are currently available.  Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast...

  
• 04.14.2023

  Mixing Laughter and Medicine with the Glaucomfleckens

  On this episode, we are joined by Dr. Will Flanary (AKA Dr. Glaucomflecken) and Kristin Flanary (AKA Lady Glaucomflecken). Dr. Flanary is a practicing ophthalmology who also creates hilarious skits incorporating a wide range of characters who worked at a...

  
• 04.04.2023

  Management of Primary-Open Angle Glaucoma *ACPE-Accredited*

  On this episode, we review the pharmacotherapy options available for managing primary-open angle glaucoma. We discuss prostaglandin analogs, beta-blockers, alpha-2 agonists, carbonic anhydrase inhibitors, cholinergics, rho kinase inhibitor, and more. We also briefly review angle-closure glaucoma to finish the episode. ...

  
• 03.29.2023

  The Psychedelic Renaissance and its Impact on Behavioral Health

  On this episode, we are joined by long-time friend of the show, Amelia Furbish, PharmD, PhD candidate, to discuss the emergence of psychedelics and their potential role in managing behavioral health conditions. If you are interested in learning more about...

  
• 03.23.2023

  Managing Irritable Bowel Syndrome *ACPE-Accredited*

  On this episode, we discuss the management and treatment of irritable bowel syndrome (IBS). We review the various medications recommended published in the 2020 American College of Gastroenterology and the 2022 American Gastroenterological Association treatment guidelines. Cole and I are...

  
• 03.14.2023

  Bempedoic Acid and the CLEAR Outcomes Trial

  On this episode, we review the recently published CLEAR-outcomes trial that was looking at bempedoic acid's (Nexletol) ability to lower the risk of CV events in patients who were unable to tolerate statins at their recommended doses. While recording this...

  
• 03.06.2023

  Treatment and Management of Anemia *ACPE-Accredited*

  On this episode, we review the treatment and management of various types of anemia. We discuss iron-deficiency anemia, B-12 and folate dificiency anemia, anemia due to CKD, anemia due to chronic disease (inflammation), and aplastic anemia.  Cole and I are...

  
• 02.28.2023

  ACP BP Goals, Ozempic Face, and Healthy Potatoes

  On this episode we cover three different topics that have been in the medical news lately. First, we compare/contrast the blood pressure goals that were published by the American College of Physicians with other prominent hypertension guidelines. Second, we discuss...

  
• 02.20.2023

  A Review of Antipsychotics *ACPE-Accredited*

  On this episode we review typical (first generation) and atypical (second generation) antipsychotics. We discuss receptor signaling, various adverse effects, and specific clinical pearls for the individual medications in the antipsychotic class.  Cole and I are happy to share that...

  
• 02.06.2023

  Does Morning or Bedtime Dosing of Antihypertensives Matter? *ACPE-Accredited*

  On this episode, we discuss dosing antihypertensives at bedtime compared to the morning and if it impacts patient outcomes. We review the MAPEC, Hygia, and TIME studies as well as other editorials on this debated topic. Cole and I are...

  
• 01.31.2023

  New Year New Drugs: Leqembi, Airsupra, and Brenzavvy

  On this episode we discuss the new drugs that have been approved in 2023 so far. We review Leqembi (lecanemab-irmb) injection for Alzheimer's disease, Airsupra (albuterol and budesonide) inhalation for as-needed use in asthma, and Brenzavvy (bexagliflozin) for type 2...

  
• 01.23.2023

  Obsessive Compulsive Disorder *ACPE-Accredited*

  On this episode, we discuss the pharmacotherapy options for managing obsessive compulsive disorder (OCD). We based our discussion on the treatment algorithm created by Dr David Osser. All of Dr. Osser's work with the Psychopharmacology Algorithms Project at the Harvard...

  
• 01.09.2023

  2023 ADA Guideline Updates *ACPE-Accredited*

  On this episode, Cole and I review some of the updates that were published in the 2023 American Diabetes Association guidelines. Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this...

  
• 01.06.2023

  Patient Case: Bipolar Disorder and Epilepsy

  Below is the patient case information: 63-year-old white male. Problem List Bipolar II disorder Insomnia Epilepsy (tonic-clonic seizures) Dyslipidemia/hypertriglyceridemia Hypertension Recent weight gain History of hyponatremia  Diabetes type 2(controlled) Medications Clonazepam 2 mg QHS Risperdal 2 mg twice daily Carbamazepine...

  
• 12.27.2022

  Insomnia Disorder *ACPE-Accredited*

  On this episode, we discuss the management of insomnia disorder. We review the criteria necessary for an insomnia disorder diagnosis. We then compare and contrast the pharmacotherapy options such as non-benzodiazepine hypnotics, benzodiazepines, anti-depressants, orexin receptor antagonists, and more.  Cole...

  
• 12.13.2022

  Pharmacologic Options for Chronic Pain *ACPE-Accredited*

  On this episode, we discuss the various therapeutic options for managing a patient with chronic pain. We discuss nonpharmacological options, anti-inflammatory medications, and other non-opioid pharmacological options. Then, we compare and contrast some of the commonly used opioids and discuss...

  
• 11.28.2022

  Generalized Anxiety Disorder *ACPE-Accredited*

  On this episode, Cole and I review the published treatment algorithm created by Harmony Raylen Abejuela, MD and David Osser, MD. This was part of the Psychopharmacology Algorithm Project at the Harvard South Shore Program. A link to the article...

  
• 11.21.2022

  Our Thoughts on the Diuretic Comparison Project (DCP)

  On this episode, we review the results that have been reported from the Diuretic Comparison Project (DCP). The point-of-care clinical trial was looking at CV outcomes based on patients using HCTZ vs chlorthalidone. We also discuss the reasons for using...

  
• 11.14.2022

  Comparison of Oral Medications for Type-2 Diabetes *ACPE-Accredited*

  On this episode, we compare and contrast oral medications that can be used to manage patients with type-2 diabetes. We review metformin, SGLT2 inhibitors, oral semaglutide, sulfonylureas, TZDs, and more.  Cole and I are happy to share that our listeners...

  
• 11.11.2022

  Updates in the Management of Amyotrophic Lateral Sclerosis

  On this episode, we review the management of amyotrophic lateral sclerosis (ALS). We discuss riluzole, edaravone, and sodium phenylbutyrate-taurursodiol (Relyvrio) that gained FDA approval in September 2022.  Thanks for listening! We want to give a big thanks to our main...