We know that there are trillions of dollars’ worth of minerals sitting on the ocean floor. The big question is whether humans should start hoovering them up.

Our guest this week is very much Pro Hoover. He’s Gerard Barron, the head of The Metals Company, which has spent years preparing to become a major player in the seabed mining industry. The company has found a spot in the Pacific Ocean that’s full of black, baseball-sized nodules rich in nickel, copper, cobalt, and manganese. In short order, The Metals Company plans to send vehicles down to gather the nodules up and then refine them.

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The pro case here is that the nodules are quite literally sitting atop the ocean floor. You don’t need to burrow into the seabed and wreak the usual environmental havoc associated with mining. You don’t need people laboring under dire conditions. And these nodules are so mineral rich that you don’t need the typical amounts of refining to get at the good stuff.

The con case is that we don’t know a ton about what goes on down there on the ocean floor in terms of animal life. Us humans could be triggering yet another environmental catastrophe on our way to harvesting what we desire.

Barron is well aware of the criticisms against seabed mining. John Oliver, among others, has gone hard at him and The Metals Company. And Greenpeace thinks Barron might be Satan.

Meanwhile, the U.S. very much wants to become a seabed mining power, as it attempts to blunt China’s dominance in critical minerals and rare earths. And, of course, the modern world depends on things like nickel, copper, cobalt, and manganese, and seabed mining looks like a very efficient way to get more of them.

We get into the pros and cons of this new field in gory detail on the pod. Some of you will be satisfied with Barron’s philosophy. Some of you won’t. In either case, you’ll come away better educated on the history of this industry and the technology driving it.

Enjoy!

The Core Memory podcast is sponsored by Brex, the intelligent finance platform. Like thousands of ambitious, innovative companies, we run on Brex so we can spend smarter and move faster. And you can too. Learn more at www.brex.com/corememory

The podcast is also made possible by E1 Ventures, which backs the most ambitious founders and start-ups.

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Jed McCaleb grew up in Arkansas where he lived in a cabin in the woods that had no electricity or running water. Now, he’s a billionaire building a space station and funding some of the world’s most adventurous science.

America remains a thing, I guess.

McCaleb, 50, has been at the center of several major technology movements. Back in the peer-to-peer glory days, he released the eDonkey application for music and file-swapping and had the pleasure of being sued by the major record labels. Then, in 2010, he launched the Mt. Gox bitcoin exchange, which dominated the crypto world until it turned into a story of mega woe.

A couple of years later, McCaleb developed the Ripple protocol before moving on to build yet more crypto innovations. This work made McCaleb fabulously well-to-do. (He’s worth $3 billion . . . if you believe Forbes.)

McCaleb has used his fortune to back a number of start-ups and philanthropic endeavors. When Elon Musk pulled out of supporting OpenAI, McCaleb helped backfill the financial vacuum. He’s also been a major investor in Max Hodak’s Science Corp., which is developing brain computer interface technology and in the rocket maker Firefly Aerospace.

McCaleb’s real blockbuster investment is Vast Space. The start-up is building a commercial space station designed to be the successor to the International Space Station, which is very much on its last legs. McCaleb says he’s prepared to put $1 billion of his fortune into Vast to make sure it happens.

My conversation with McCaleb travels across these various tech eras. He comes off, at least to me, as an oddly down-to-Earth guy for someone who invests in such a variety of wild ideas.

Enjoy!

The Core Memory podcast is sponsored by Brex, the intelligent finance platform. Like thousands of ambitious, innovative companies, we run on Brex so we can spend smarter and move faster. And you can too. Learn more at www.brex.com/corememory

The podcast is also made possible by E1 Ventures, which backs the most ambitious founders and start-ups.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe

We have a proper treat this week. Core Memory special correspondent Eryney Marrogi comes on the pod.

Marrogi is a scientist and soon-to-be doctor who has followed the rise of the gene editing tools at humanity’s disposal. He wrote a piece for us a couple of months ago on “Baby KJ,” the child who received a customized, life-saving gene therapy in record time. Now we get into what Baby KJ means for the future of gene therapies.

The gene therapy field is advancing quickly but remains costly and technically complex. Marrogi breaks down how hopeful people should be – or not – that new techniques can be applied to more than super rare, single gene problems.

We also get into the ups and downs of the DIY Bio movement, Marrogi’s work creating gene-edited mosquitoes and the vaping crisis he sees with America’s youth, who are taking in unfathomable levels of nicotine.

Enjoy!

The Core Memory podcast is sponsored by Brex, the intelligent finance platform. Like thousands of ambitious, innovative companies, we run on Brex so we can spend smarter and move faster. And you can too. Learn more at www.brex.com/corememory

The podcast is also made possible by E1 Ventures, which backs the most ambitious founders and start-ups.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe

In the 1970s, scientists created the first wiring diagram of a worm brain. To do this, they sliced up a worm, imaged the slices under microscopes and then reconstructed a map of the worm’s neurons and their synaptic connections. Wonderful. (It was 302 neurons and really a map of the worm’s central nervous system.)

We haven’t come terribly far since then. It took until 2024 for scientists to create a full map – aka a connectome – of an adult fly brain (140,000 neurons) and researchers now dream of completing similar work for a mouse brain and one day perhaps a human brain with its 80 billion neurons and one trillion connections.

The belief is that if we have a proper wiring diagram of the brain, we will understand the brain and how it works much better.

Things have been slow and hard because mapping something like a mammalian brain requires a lot of laborious work, tons of computing power and some method for labeling all the neurons and their connections in a comprehensible and useful fashion.

E11 Bio was founded in 2021 to try and develop new techniques for mapping brains faster and cheaper. And today marks a big moment in the organization’s history. The E11 Bio team has published a paper – in conjunction with loads of high-profile contributors – detailing the success of its techniques. (There’s much more info on E11’s web site here and here.)

In very simplified terms, E11 can put viruses in the brain that carry proteins to neurons. Those proteins then distribute markers across the neurons that make them light up in different colors under a microscope. This technology has made it much easier to find individual neurons and trace their connections.

E11’s co-founder and CEO Andrew Payne was kind enough to come on the podcast to discuss the organization’s work and its brain mapping process. We also got into why this all matters, the challenges ahead and where neuroscience and artificial intelligence overlap.

Enjoy!

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The Core Memory podcast is sponsored by Brex, the intelligent finance platform. Like thousands of ambitious, innovative companies, we run on Brex so we can spend smarter and move faster. And you can too. Learn more at www.brex.com/corememory

The podcast is also made possible by E1 Ventures, which backs the most ambitious founders and start-ups.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe

In this episode, Dan Wang comes on the show to discuss his new book Breakneck: China’s Quest to Engineer the Future.

I’ll start by noting that the book is fantastic, and you should read it. It’s a well-researched, vibrant account of how China became dominated by its engineering culture. The country has displayed an unmatched ability to build over the past forty years, and Wang traces the scale of these accomplishments in detail. He also documents how pervasive this engineering mindset is by diving into the one-child and zero-Covid policies, and the brutally efficient ways they were carried out.

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Wang contrasts China’s engineering-first culture with the US’s regulation-first culture. China’s top politicians are mostly engineers. The US’s top politicians are mostly lawyers. Wang argues that the US once built like China until the 1960s came, and the US began regulating itself into a collective torpor.

As you’ll find in the book and hear in our discussion, Wang is not a China propagandist. Far from it. He offers a sober look at the pros and cons of both China and the US and points out that the two cultures have remarkable similarities.

In this episode, we explore the book and much beyond it, discussing what hope, if any, the US has of competing against China in the coming century.

Enjoy!

The Core Memory podcast is sponsored by Brex, the intelligent finance platform. Like thousands of ambitious, innovative companies, we run on Brex so we can spend smarter and move faster. And you can too. Learn more at www.brex.com/corememory

The podcast is also made possible by E1 Ventures, which backs the most ambitious founders and start-ups.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe

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In January of 2024, Noland Arbaugh became the first human to receive one of Neuralink’s brain-computer interface implants.

Ahead of that surgery, Neuralink pulled off a first-of-its-kind engineering feat. The company created a detailed replica of Arbaugh’s skull and brain. With this replica, Neuralink’s surgeons and its surgical robot could practice the …

This week, we bring you the story of California Forever in all its “never told before” glory.

For the past eight years, Jan Sramek and a group of wealthy investors have been buying up land in Solano County with the hopes of creating a great new city in Northern California. All told, the California Forever group has spent $1 billion to acquire 68,000 acres (100 square miles) in an area about halfway between San Francisco and Sacramento. Their goal is to create a community of 400,000 people who can live and work together and to make it possible for California to manufacture more of the things that it invents in state.

The Czech-born Sramek became consumed by the idea of founding a new city after experiencing California’s well-known problems – expensive real estate/lack of housing, long commutes in heavy traffic, loss of manufacturing jobs and skills, and over-regulation – firsthand. And, sort of insanely, he decided to try and do something about it. He set out to see if California still had the will and the way to make a shining new city.

(TL;DR: In this episode, Sramek tells the full story (for the first time) of how California Forever was created and pushed forward, including the incredible lengths he had to go through to keep the project secret. We, of course, also get into much of Sramek’s reasoning for wanting to dedicate his life to this project and why he cares about trying to help California thrive.)

Sramek managed to convince an all-star cast of investors to buy into his plan. California Forever is backed by the likes of Patrick and John Collison, Michael Moritz, Laurene Powell Jobs, Marc Andreessen, Daniel Gross and Nat Friedman. Together, these people bought up the Solano County land in relative secrecy over the course of about six years and have set to work putting in the regulatory structure needed to get building. Their current plan includes not just the city itself but also nearby manufacturing and shipbuilding hubs.

The project has, naturally, run into controversy. People have grumbled about the billionaires being up to something shadowy. Others have complained about building on land historically used for ranching and about potential environmental concerns. At one point, local politicians even suggested that perhaps China was buying up the land so that it could spy on Travis Air Force Base.

For a while, it appeared that the naysayers might win and stall California Forever indefinitely. But the combination of a second Donald Trump election and the widespread feeling that California is over-regulating itself into oblivion have injected new life and enthusiasm into the California Forever effort. Many people and politicians in Solano County are now looking to join up with the project and help make it happen.

Not everyone will agree with me here. This is natural. But, for me, California Forever represents an existential moment for the wonderful state that I call home.

Nowhere on Earth do people have it better than Californians. But we are on the verge of the greatest economic self-own in history if we can’t learn how to build and develop and do big things again. We must get out of our own way and create a system that allows for hope and optimism and the notion of creating a better future.

Building a picturesque city where people can live close to their jobs and manufacture the products that they invent on underutilized land should not be controversial. It should just happen.

If we can’t let something like California Forever flourish, we’re signaling that California has lost its way, its spirit and its ability, and this strikes me as profoundly sad.

The Core Memory podcast is sponsored by Brex, the intelligent finance platform. Like thousands of ambitious, innovative companies, we run on Brex so we can spend smarter and move faster. And you can too. Learn more at www.brex.com/corememory

The podcast is also made possible by E1 Ventures, which backs the most ambitious founders and start-ups.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe

Most of you have not heard of Axon Enterprise. But there it is – a $57 billion company that has reshaped pretty much every police department in the United States. (San Francisco being the major exception.)

Rick Smith founded the company in 1993 and turned its major invention – the TASER – into a blockbuster product. Smith hoped the taser would lessen cops’ inclination to grab their guns by giving them a non-lethal option for dealing with dangerous situations. In more recent years, Axon has moved into body cameras, drones and software and data systems used by police forces.

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The taser was never going to be without controversy, and Smith and Axon have found themselves under scrutiny time and again. John Oliver recently spent thirty minutes on a taser takedown and mocked Smith. In 2023, Reuters also went at Axon, accusing Smith of making up the company’s founding story, over-paying his executives and maintaining an “unusual” workplace culture. (In this podcast, Smith answers the founding story accusations for the first time with a journalist.)

Despite the digs and plenty of lawsuits, Smith has spent three decades on this singular quest of changing the nature of policing. Axon can point to plenty of data that show tasers have reduced officer shootings, and body cams have added transparency to the actions of both cops and criminals.

In its next turn, Axon hopes to build taser-equipped drones that can be used to assess and deal with incidents. Smith has even talked about using these types of drones to patrol schools and protect against active shooters – yet another controversial idea.

In this episode, we get into the history of Smith and Axon, how the company’s technology works, all of the controversies and where Axon is heading.

Enjoy!

The Core Memory podcast is sponsored by Brex, the intelligent finance platform. Like thousands of ambitious, innovative companies, we run on Brex so we can spend smarter and move faster. And you can too. Learn more at www.brex.com/corememory

The podcast is also made possible by E1 Ventures, which backs the most ambitious founders and start-ups.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe

Cathy Tie has been having an eventful year.

First she co-founded a company determined to gene edit animals and build literal unicorns. Then she held a wedding ceremony in China with Dr. Jiankui He - the controversial scientist who spent three years in prison for performing gene editing procedures on twins. And then, in May, we brought you the story of Tie being banned from China with government officials apparently not liking the idea of her teaming up with Dr. He romantically and/or professionally.

Well, Tie is back in the U.S. now and has just started the Manhattan Project – a start-up that unapologetically seeks to perform gene editing on embryos to block them from inheriting diseases. It’s controversial and then some just like Tie herself.

In this exclusive podcast, Tie discusses her plans for the Manhattan Project, her whirlwind 2025 and her efforts to push the bio-tech field into a new era.

Enjoy!

The Core Memory podcast is sponsored by Brex, the intelligent finance platform. Like thousands of ambitious, innovative companies, we run on Brex so we can spend smarter and move faster. And you can too. Learn more at www.brex.com/corememory

The podcast is also made possible by E1 Ventures, which backs the most ambitious founders and start-ups.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe

Into the brain we go.

Sumner Norman, the co-founder and CEO of Forest Neurotech, comes on the show to take us on a journey across the history and future of brain implants. We start with the first experiments prodding the body and mind with electricity and end up in mind uploading land. Along the way, we cover many of the major brain-computer interface technologies and advances.

Norman has a unique perspective in this field. He’s a mechanical engineer by training but can talk neuroscience with the best of them. I’ve always found him to be realistic and fair with his assessment of various brain-computer interface approaches.

Forest Neurotech makes a brain implant that uses ultrasound to analyze the mind. The company argues that its approach allows it to see more of what’s happening in a brain than electrode-based implants - from Neuralink, Synchron, et al. - that can only probe the small areas where they sit next to neurons. It has been running trials with its implant in a bid to help doctors and patients better understand the nature of mental disorders.

In a fascinating turn, Forest has started to detect "covert consciousness" in comatose patients who are otherwise completely unresponsive. The people appear to be able to hear and interpret what is being said around them. This is both comforting and not.

The ultrasound approach that Forest helped pioneer is now starting to look like a thing with other start-ups using similar techniques.

Beyond Forest, we get into the economics of the BCI industry, its promises and limitations and, of course, cover much sci-fi ground.

Enjoy!

The Core Memory podcast is sponsored by Brex, the intelligent finance platform. Like thousands of ambitious, innovative companies, we run on Brex so we can spend smarter and move faster. And you can too. Learn more at www.brex.com/corememory

The podcast is also made possible by E1 Ventures, which backs the most ambitious founders and start-ups.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe