Core Memory

A few years ago, some people put me in a van and drove me to the edge of Moscow. And by “the edge of Moscow,” I mean where things started to get a bit rural. We turned off a road and went toward what looked like a modest farmhouse with a shed. After exiting the van, we entered said shed and found two large metal containers that were full of human bodies and heads along with the bodies of many animals, including dogs, cats, and a hummingbird. Have a look.

These bodies were being cryopreserved with liquid nitrogen in the hope that they could be reanimated at some point in the future when science has advanced and more illnesses can be cured.

Cryopreservation/reanimation is not a new idea. It’s been contemplated in literature for hundreds of years. Alcor, perhaps the most well-known cryopreservation company, was founded way back in 1972. The field, though, has suffered from questionable science and been seen as a scientific backwater.

Our guest this week wants to add scientific, intellectual, and pragmatic rigor to the cryopreservation field or what he calls the biostasis field. He’s Dr. Emil Kendziorra, the founder and CEO of Tomorrow Bio.

Tomorrow Bio has a team that will show up at the end of life and prepare someone’s body for preservation and then store their body in a Swiss vault.

In this episode, we get into the mechanics behind Tomorrow Bio and the pros and cons of biostasis. Kendziorra is a sober, deep thinker on this topic and a great listen.

OUR SPONSOR

BREX

The Core Memory podcast is sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.

We run on Brex and so should you. Learn more about Brex right here.

TIMESTAMPS (they link out to YouTube)

CHAPTERS0:00 Intro5:08 Cryonics Without the Ice8:45 Heads in a Russian Shed12:26 Longevity's Backup Plan19:39 The First Hours After Death30:11 Funding a Second Life37:15 Does Cryonics Actually Work?43:40 Preserving Brains Without Bodies50:52 Why Not Reverse Aging?55:21 Can the Company Outlive You?1:03:37 Waking Up Centuries Later1:08:28 The Problem of Rewarming1:15:14 Selling Hope Without Overselling Science1:19:40 Would Longer Lives Be Better?1:23:42 Elective Cryonics and Family Life

We’ve heard a lot of moonshot ideas on this podcast, but this week’s guest may have the most impossible one yet: making tech more cultured.

In this episode, Ashlee sat down with Anna Gát, a Hungarian philosopher, playwright, and founder of Interintellect, a platform for hosting intellectual conversations online. She calls herself “the bridge” between the humanities, academia, and the tech world, which in practice means getting engineers to read Goethe.

Gát grew up on a TV set in communist Hungary. Her parents made the country’s biggest shows in an era when there was one channel available on Saturdays. In 2015, a family crisis left her starting over in London with two suitcases, one of them for books. She rebuilt her life on Twitter, DM’d Sam Altman, and got him as her first meeting on her first trip to America.

Before Interintellect, Gát did just about every wordcel job you can do: playwright, screenwriter, script doctor. She holds graduate degrees in philosophical aesthetics and linguistics, currently splits her time between SF and NYC. The company that would become Interintellect began in London in 2016 as an AI tool for helping “humans have categorically better conversations.” On the side, she angel invests in aerospace.

The two get into why X was once the French café that could publish you and is now a place you can’t get discovered from, why the East Coast’s healthiest, wealthiest people are so convinced the future is doomed, and the duty AI builders have to explain themselves. Gát also admits, on the record, that she’s a sucker for Elon Musk’s syntax. Ashlee tries to convince her that kids don’t read books anymore. She tries to convince him Silicon Valley should fund symphonies.

IN THIS EPISODE

Interintellect — https://www.interintellect.com

The Hope Axis — https://twitter.com/TheHopeAxis

Anna on X — https://x.com/TheAnnaGat

OUR SPONSORS

BREX

The Core Memory podcast is sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.

We run on Brex and so should you. Learn more about Brex right here.

SENDCUTSEND

You know who else makes stuff for America? That would be SendCutSend. If you want to celebrate our great nation by building a metal part, then head on over to SendCutSend where you’ll get a 15 percent discount thanks to Core Memory on whatever you’re trying to build. We believe in you.

TIMESTAMPS

0:00 — Intro

2:56 — The science of dialogue

6:34 — Growing up famous in communist Hungary

13:06 — Nobody saw 1989 coming

16:43 — Losing everything in 2015

20:57 — Silicon Valley as the new Ellis Island

28:38 — Balaji's DAO campaign33:42 — Elon's syntax

39:18 — Why does America hate tech?

46:25 — Engineers took over the world

53:20 — Have LLMs solved language?

1:01:29 — Are books dying?

1:06:51 — No Pop-Tarts

1:10:46 — Who funds culture?

In this episode, Ashlee sits down with Joel Jean, CEO of Swift Solar, a San Carlos-based startup trying to create new solar technology using perovskite. We previously published a story about Swift, if you’re wondering what the f*ck perovskite is! In short, it’s a synthetic crystal that turns sunlight into electricity better and cheaper than the silicon currently used in solar panels. This stuff is finicky though, and experts have doubts, as they always do — but Jean explains how Swift is closing in on a solution.

“Everyone and their mom can make a perovskite that’s decently efficient,” Jean says, but no one seems capable of making it as durable as silicon. The material degrades under heat, light and its own moving ions. This is obviously not the ideal situation for an energy grid.

So why not stick with silicon? Well, the laws of physics haven’t quite blessed it. A silicon panel can turn, at most, about 30 percent of the sunlight it gets into electricity, and today’s panels usually churn out about 25 percent. If they’re able to successfully layer perovskite on top, that pushes the ceiling to 45 percent.

These are fabulous gains in the solar nerd world, and we could really use some innovation here because we are one very, very energy-hungry species. And of course, this is Core Memory, so you know where this is headed: China and AI.

China makes 90 percent of the world’s solar cells and wafers, installs more panels than the rest of the planet combined, and builds the machines that nearly every U.S. solar factory runs on. (Except for Swift, apparently!). That dependency is, as always, a risk.

Meanwhile, AI data centers need more power than God, and the folks making models are happy to welcome any new gains in that department. Some are even putting their money on it; renowned AI researcher Jeff Dean has invested Swift.

Charge your crystals, folks. We’re perovskite-maxxing.

IN THIS EPISODE

This Is The U.S.’s Last Chance At Solar — Core Memory

Swift Solar

Meyer Burger acquisition

Joel's "solar for AGI" piece

OUR SPONSORS

BREX

The Core Memory podcast is sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.

We run on Brex and so should you. Learn more about Brex right here.

SENDCUTSEND

You know who else makes stuff for America? That would be SendCutSend. If you want to celebrate our great nation by building a metal part, then head on over to SendCutSend where you’ll get a 15 percent discount thanks to Core Memory on whatever you’re trying to build. We believe in you.

TIMESTAMPS

00:00 — Intro

04:56 — How The U.S. Lost Solar1

2:36 — Maxed-Out Physics

20:03 — How China Won

27:53 — What Is Perovskite?

36:52 — The 30-Year Problem

45:41 — China's Scale-First Bet

51:00 — The Meyer Burger Deal

58:50 — Can Solar Power AI?

1:09:43 — Patents, China And The Machines

1:22:15 — Solar For AGI

This episode is nerd catnip unlike anything I’ve ever seen before.

Ashlee sat down with Seamus Blackley, who you might know as the man who talked Microsoft into building the Xbox. Nowadays, you can find Blackley in a Pasadena laboratory making the world’s best chocolate. If you’re just here for the cacao, well, we did a video on it.

Blackley grew up in rural New Mexico and studied electrical engineering, then physics, at Tufts University. He spent years working on titles you know and love, like Madden, and ones perhaps you don’t, like Jurassic Park: Trespasser, a flop notorious enough to earn him his first death threats.

Also, Ashlee is away for a few weeks on a big video shoot in India, which means I, Kylie, will be filling in on all the writing stuff. Now that you know who the voice of God is here, let’s get into the most important thing — what I think about this episode!

Blackley is totally captivating and eccentric, exactly the way you’d expect a physicist who builds holograms and runs a chocolate farm to be. He got deep in ways I didn’t expect, about his abusive childhood and what it was like working at Microsoft. I particularly loved this line from him:

“The khaki pants wearing guys, the lifers, they show up and we had fought them to keep them away from [the Xbox]. The more we kept them away from it, the more consumers got excited because we were talking about things with the power of Microsoft and not the b******t of Microsoft. That was incredibly effective. But it was exhausting and it was a conscious effort of will to fight it. At some point it was going to destroy me and I had to stop.”

Blackley seems to talk at 2x speed naturally, and I’m grateful for it, because he has no shortage of brain-exploding lore to fit into these 80 minutes. He describes his whole career as “one long tale of woe and rapid dancing in the face of failure,” which is a very modest way to describe inventing the Xbox, shepherding Guitar Hero into existence, and abducting Jimmy Fallon. You’ll have to listen for that last one.

IN THIS EPISODE

Core Memory on Seamus Blackley's chocolate experimentSmithsonian Magazine on Blackley's ancient Egyptian bread projectPacific Light & Hologram

OUR SPONSORS

BREX

The Core Memory podcast is sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.

We run on Brex and so should you. Learn more about Brex right here.

SENDCUTSEND

You know who else makes stuff for America? That would be SendCutSend. If you want to celebrate our great nation by building a metal part, then head on over to SendCutSend where you’ll get a 15 percent discount thanks to Core Memory on whatever you’re trying to build. We believe in you.

TIMESTAMPS

* 00:00:00 — Intro

* 00:02:38 — Why Tech Hype Sucks

* 00:07:37 — Why Talking About Your Work Kills It

* 00:10:42 — Early Life, Physics, and Jazz

* 00:21:57 — Fermilab & Academic Politics

* 00:30:47 — Building the First 3D Video Game Engines

* 00:34:18 — Early Game Development Culture

* 00:38:37 — DreamWorks & Working for Steven Spielberg

* 00:44:32 — Joining Microsoft & Pitching the Original Xbox

* 00:54:04 — Fighting Corporate Bureaucracy to Save Xbox

* 01:03:42 — Abducting Jimmy Fallon

* 01:07:20 — Baking Bread with 4,500-Year-Old Egyptian Yeast

* 01:10:40 — Growing Cacao Trees in a Lab

* 01:17:09 — Accidentally Launching a Chocolate Empire

We have been promised glorious gene therapies for decades. This is supposed to be the stuff of reprogramming the body to blunt or cure diseases with something approaching a permanent fix. While gene therapy progress has been made, treatments remain rare and expensive, and it’s very tough to get the therapies to go into the desired parts of the body.

Our guest this week is here to help. He’s Adrian Veres, the chief scientific officer and co-founder of Dyno Therapeutics. Founded in 2018, Dyno has been pursuing new and better ways to deliver gene therapies via modified viruses.

Dyno was well ahead of the AI meets biotech curve, using AI models to design new viral shells that let genetic instructions get into the right places of the body. For the moment, Dyno has focused on creating delivery mechanisms for companies working on therapies aimed at the brain, eye and muscles.

In this episode, we talk with Veres about the promise and perils of gene therapy technology, some of the most recent cases where gene therapies worked and how Dyno’s technology came to be and functions. And we get Veres’s take on whether or not we’re entering a golden age of biotech on the back of AI.

Due to some poor camera work on my part, Veres, who is a tall man, looks particularly giant. Fear not, he did not harm me and was actually quite nice.

OUR SPONSORS

BREX

The Core Memory podcast is sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.

We run on Brex and so should you. Learn more about Brex right here.

SENDCUTSEND

You know who else makes stuff for America? That would be SendCutSend. If you want to celebrate our great nation by building a metal part, then head on over to SendCutSend where you’ll get a 15 percent discount thanks to Core Memory on whatever you’re trying to build. We believe in you.

IN THIS EPISODE

Dyno Therapeutics: https://www.dynotx.com/

The FDA framework for individualized ultra-rare disease therapies: https://www.fda.gov/news-events/press-announcements/fda-launches-framework-accelerating-development-individualized-therapies-ultra-rare-diseases

Core Memory on Baby KJ and the new gene therapy playbook: https://www.corememory.com/p/the-new-gene-therapy-playbook-babykj

Core Memory’s gene-editing conversation with Eryney Marrogi: https://www.corememory.com/p/the-state-of-gene-editing-eryney-marrogi

Core Memory’s podcast with Jennifer Doudna: https://www.corememory.com/p/the-present-and-future-of-gene-editing-jennifer-doudna-crispr

TIMESTAMPS (they link out to YouTube)

0:00 Intro

3:34 Why Does Gene Therapy Still Feel Rare?

7:38 What Is Gene Therapy, Really?

14:48 How Do You Deliver DNA?

17:47 Turning a Virus Into Medicine

21:53 The 700-Letter Box

28:20 Testing a Million Designs at Once

34:28 Why Does the Liver Steal the Cure?

36:43 Getting Past the Brain’s Bouncer

43:04 Is Delivery the Missing Piece?

47:24 Can Million-Dollar Therapies Get Cheap?

52:10 Did Dyno Start Too Early?

1:00:03 Was Biology Oversold?

1:09:36 Will We Cure Every Disease in 10 Years?

1:18:20 Should You Build Your Own Peptide Stack?

1:20:55 Is China Winning the Biology Race?

1:27:40 What Baby KJ Changed

1:32:34 Should the Next Generation Study Biology?

Over the past five years, Alex Colville has become one of the most influential figures in the longevity and aging fields.

There’s a decent chance you have not heard of him, which is a bit by design. Unlike many longevity gurus, Colville does not seek much attention and, for the most part, operates in the background where he’s been doling out many millions of dollars in investments. Today, Colville runs age1, a venture capital firm that has backed the likes of Loyal, Science, Conception and a bunch of other companies listed as “Stealth” on its web site.

Colville is the guy I call to reality check whatever is being hyped up in Longevity Land. He studies the actual science. He reaches sober conclusions. He’s honest about where the technology is today and what might show promise in the future.

In this episode, we get into Colville’s takes on GLP-1s, partial cell reprogramming, China’s biotech rise, the odd animals teaching us the most about longevity and, well, the prospects of living forever. We also get into Colville’s life and unusual rise as the longevity kingmaker, and, of course, we discuss keeping a human head alive without a body because what choice did we have.

If you can spare a minute, please do us a favor by filling out this ever so brief survey, so we can learn a bit more about our subscribers. Help us be better for you. Thanks!!

OUR SPONSORS

SendCutSend

You know who else makes stuff for America? That would be SendCutSend. If you want to celebrate our great nation by building a metal part, then head on over to SendCutSend where you’ll get a 15 percent discount thanks to Core Memory on whatever you’re trying to build. We believe in you.

Brex

The Core Memory podcast is also sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.

Did we go to Texas, find a telescope ranch and then obtain an entire nebula in Brex’s honor? Oh yes, we did.

We run on Brex and so should you. Learn more about Brex right here.

Timestamps (they link out to YouTube)

0:00 Intro2:41 Meet the Switzerland of Aging8:01 Why Did Aging Become the Enemy?10:28 What Can an Axolotl Teach Us?26:23 What Works in Worms, but Not Yet in Humans?30:16 The Longevity Expert Who Takes Nothing34:37 Are GLP-1s Already Anti-Aging Drugs?44:14 Can We Make Old Cells Young Again?58:48 What Do Hibernating Squirrels Know?1:05:02 When Does Medicine Become an Upgrade?1:09:57 Has CRISPR Lived Up to the Hype?1:12:43 What Are Altos and Calico Really Doing?1:20:24 The Breakthrough That Could Change Everything1:25:14 Will China Win the Biology Race?1:28:24 Why a Virtual Cell Is Not a Cell1:30:28 A Head in a Waymo?

Every couple of days, a new AI-meets-biotech startup sends me a pitch, and the pitches all sound the same. AI is amazing, and it can now tame biology. We’re on the cusp of producing new cures for diseases at a rapid rate, and these startups know just how to get the job done. To which you should wonder – is this at all true?

On this week’s Core Memory episode, we have brought in the big brains to answer – or at least debate – this question. Our resident science whiz and medical professional Eryney Marrogi takes on the hosting duties to interview Abhishaike Mahajan, he of Owl Posting and now OpenAI Foundation fame.

These two men of science take hold of this AI/biotech moment to explore where we’re seeing the most promise from this new wave of technology and where the messiness of biology continues to confound AI. They also get into some lighter topics like our collective death from AI bioweapons and China’s impending biotech dominance. Good times.

You’re all probably buzzing over Moderna’s stock price doubling and the end of cancer. So ride that enthusiasm right into this podcast and see how you’re feeling on the other side.

If you can spare a minute, please do us a favor by filling out this ever so brief survey, so we can learn a bit more about our subscribers. Help us be better for you. Thanks!!

OUR SPONSORS

SendCutSend

You know who else makes stuff for America? That would be SendCutSend. If you want to celebrate our great nation by building a metal part, then head on over to SendCutSend where you’ll get a 15 percent discount thanks to Core Memory on whatever you’re trying to build. We believe in you.

Brex

The Core Memory podcast is also sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.

Did we go to Texas, find a telescope ranch and then obtain an entire nebula in Brex’s honor? Oh yes, we did.

We run on Brex and so should you. Learn more about Brex right here.

Timestamps (they link out to YouTube)

0:00 Intro4:24 Is Intelligence the Bottleneck?6:58 A Thousand von Neumanns12:29 The Cancer Drug That Failed21:15 Can AI Read a Tumor?31:38 Is Text All You Need?44:39 The Machine Nobody Built54:16 A Trillion Dollar Organoid?1:02:26 Biosecurity Lost the Plot1:06:02 ChatGPT vs. a Virus1:19:13 Why the Terrorists Failed1:24:37 Who Gets to Order DNA?1:42:41 China Wins Biology1:53:41 The Lab Nobody Funds

Thanks for listening!

Most people think that the Red Bull guy Felix Baumgartner holds the skydiving record. But this is not the case.

The real record-holder is Alan Eustace. In 2014, at age 58, the Google engineer rode a helium-filled balloon into the stratosphere and then fell back to Earth from 135,890 feet. Eustace’s fall lasted 4 minutes and 27 seconds, and he broke the sound barrier, reaching a max speed of 822 mph. And now, in a very rare appearance, Eustace has come on the podcast to discuss his adventure.

Baumgartner, who dropped from 128,852 feet, received tons of attention because Red Bull turned his jump into a media spectacle. Eustace, by contrast, came up with the plan for his jump and spacesuit at his kitchen table, paid for a small team to help him build his suit and then did his skydive with just a single reporter there as a witness.

This all fits with Eustace’s personality. He’s quite private and just goes about his work.

It took several months of begging to get Eustace on the show, and I don’t think he’s ever discussed his skydive in this type of detail before.

In this episode, we get into what drove a 58-year-old man to want to chase this feat, the rich history of stratosphere jumping and Eustace’s remarkable career as one of the key Google engineers who built the modern internet. We also hear Eustace’s thoughts on AI and his latest quest to search the ocean floor.

(I apologize for saying that Eustace jumped from space in the episode. It was the stratosphere. I was excited.)

If you can spare a minute, please do us a favor by filling out this ever so brief survey, so we can learn a bit more about our subscribers. Help us be better for you. Thanks!!

OUR SPONSORS

SendCutSend

You know who else makes stuff for America? That would be SendCutSend. If you want to celebrate our great nation by building a metal part, then head on over to SendCutSend where you’ll get a 15 percent discount thanks to Core Memory on whatever you’re trying to build. We believe in you.

Brex

The Core Memory podcast is also sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.

Did we go to Texas, find a telescope ranch and then obtain an entire nebula in Brex’s honor? Oh yes, we did.

We run on Brex and so should you. Learn more about Brex right here.

Timestamps (they link out to YouTube)

00:00 Intro03:26 Chasing Alan Eustace07:42 Rocket Sleds and Seatbelts10:38 Why Build a Capsule?13:00 Kittinger’s Three Jumps18:11 The Idea Takes Hold21:07 Elon’s Mars Greenhouse23:18 The Jump That Failed28:37 Solving the Death Spin30:07 Racing Red Bull32:26 One Reporter, No Livestream34:12 The Kittinger Coincidence38:26 Not Your Typical Daredevil40:43 Goodbye Videos for His Kids44:35 The First Spacesuit Jump48:37 Two Hours to Space50:53 Google Earth in Reverse54:36 Can I Get a Countdown?58:55 Breaking the Sound Barrier1:00:08 The Crash Landing1:02:16 What It Really Cost1:08:28 The Magic of Gas Balloons1:10:30 Did the Jump Change Him?1:17:03 The VLSI Golden Age1:22:56 Is AI Revolutionary?1:29:20 The Google Translate Story1:35:49 The Fall of DEC1:41:09 Reinventing the Data Center1:48:51 Impossible to Inevitable1:51:40 Inside Commonwealth Fusion1:56:21 Hunting Amelia Earhart2:03:21 What’s Under the Golden Gate?

Treating cancer remains a crude practice. We cut, burn and poison tumors, and we do all this with relatively little precision around both the initial treatment and our ongoing monitoring of how effective the treatment is. You show up for scans now and again and hope that whatever you’ve been doing has been working.

Ben Woodington - who is an absolute unit - and the team at Coherence have come up with a new way to monitor and treat tumors. They’ve built an implant that, as the name suggests, gets placed inside the body to keep a constant watch on a tumor’s behavior. The chip also brings with it the ability to deliver electrical signals that may blunt a tumor’s growth. We’re talking constant monitoring of a tumor to see if treatments are working and the ability to read and write electrical signals as part of a totally novel bio-tech device.

In this episode, Ben explains how this technology works and, more broadly, he walks us through the emerging field of neuro-oncology or cancer neuroscience. We have a look at Coherence’s device, which is reminiscent of Neuralink’s implant, and rival technology.

Since we recorded this episode, Coherence has begun a study in Australia where its device is being used to record and stimulate brain activity in patients having brain tumors removed. The company has also put out a paper detailing some of its work and has brought on Neuralink’s neurosurgery lead Matthew MacDougall as an advisor and investor.

This episode was a treat for me because I had no idea this type of technology even existed, and because Coherence seems to have made a remarkable amount of progress on its hardware in a short time.

If you can spare a minute, please do us a favor by filling out this ever so brief survey, so we can learn a bit more about our subscribers. Help us be better for you. Thanks!!

OUR SPONSORS

SendCutSend

You know who else makes stuff for America? That would be SendCutSend. If you want to celebrate our great nation by building a metal part, then head on over to SendCutSend where you’ll get a 15 percent discount thanks to Core Memory on whatever you’re trying to build. We believe in you.

Brex

The Core Memory podcast is also sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.

Did we go to Texas, find a telescope ranch and then obtain an entire nebula in Brex’s honor? Oh yes, we did.

We run on Brex and so should you. Learn more about Brex right here.

Timestamps (they link out to YouTube)

0:00 Intro3:54 Cut It, Poison It, Burn It. Is There a Fourth Way?6:16 Your Tumor Is Rewiring Your Brain8:29 The Clunky Device That Somehow Already Works11:35 Why Patients Take It Off15:12 Inside the Implant: A Neuralink for Tumors20:32 Could a Chip Replace the MRI?27:13 What the Mice Are Already Telling Them31:38 First Humans, and Why It's Always Australia35:36 "They Should Have Hired a Few Apple Engineers"43:24 Neuralink vs ONWARD: Who's Right About the Spine?47:09 The Idea Nobody Else in Neurotech Had1:01:45 Cut One Nerve and the Cancer Stops Spreading1:06:12 A Cancer Sensor Inside All of Us?1:09:12 Do Cancer Drugs Work Better Before 11 a.m.?1:14:59 If AI Ran Medicine, It Would Build This

Running a media business is hard. You’re competing for people’s attention. You must produce a relentless stream of new things that are good and different. And you’re often dependent on the ever-changing whims of the public and advertisers.

John Coogan and Jordi Hays somehow made all of this look easy when they started TBPN in late 2024. The daily tech ne…