Australia's unique biodiversity, a product of almost 50 million years of glorious evolutionary isolation, is in freefall. The threats are not just the rabbits, the cane toads, the cats and foxes – the common culprits. Let's not forget the small but impactful smooth newt or the fierce red fire ants, and the many invasive weeds. Twenty new weeds will establish in the wild in Australia this year – and every year to come … unless things change. But is it possible to stop this ongoing invasion? How do we go about it?