In this episode, we discuss the recently published Tigris trial, which evaluated the role of Polymyxin B hemoadsorption in patients with septic shock. We explore the trial’s rationale, trace the evolution of evidence in this area, examine its analytical approach (Bayesian vs. frequentist), and unpack the results. We also discuss the study’s strengths and limitations, and highlight the key takeaways.

We’re excited to introduce Beyond the Data (BTD), a new CRITKNOW series where we invite expert clinicians and researchers to share their insights and interpret results beyond the numbers.

In this first episode, we’re honoured to host Prof. Ram E Rajagopalan, a highly respected senior clinician, who shares his perspectives on the evolution of HFNC use, the SOHO trial, and much more.

In this third episode of our podcast, we discuss the recently published SOHO trial. We explore the physiological benefits of HFNC, review the existing evidence, and critically appraise the trial. We also include a brief methods segment on sample size estimation and its common pitfalls.

Welcome to the 2nd episode of CRITKNOW! In this episode we are focusing on the RSI trial that compared Ketamine vs. Etomidate for intubating critically ill patients.

CRITKNOW will focus on a variety of themes related to the practice of evidence-based critical care and is co-hosted by Bharath Kumar Tirupakuzhi Vijayaraghavan and Ramesh Venkataraman.

Bharath is a mid-career clinician–researcher with a primary focus on improving outcomes from critical illness in patients in low- and middle-income countries (LMICs). He is also deeply passionate about teaching evidence-based medicine and helping clinicians interpret and apply emerging evidence in patient care. You can learn more about his work here: https://www.researchgate.net/profile/Bharath-Kumar-Tirupakuzhi-Vijayaraghavan?ev=hdr_xprf

Ramesh is American Board–certified in Internal Medicine, Critical Care Medicine, and Neurocritical Care. He is also a senior researcher with a special interest in acute kidney injury and renal replacement therapies. A highly respected teacher, he has a unique ability to integrate emerging evidence into bedside clinical practice. You can learn more about his work here: https://icuconsultants.com/dr-ramesh-venkataraman/

Bharath and Ramesh are both Senior Consultants in the Department of Critical Care Medicine at Apollo Hospitals, Chennai and affiliated with Chennai Critical Care Consultants Private Limited, an academic critical care group practice (https://icuconsultants.com/). Bharath is also affiliated with the University of Edinburgh as a Clinical Research Fellow (https://inflammation-research.ed.ac.uk/research/research-groups/dr-bharath-kumar)

Views expressed are personal.

We are also complementing the content here with a blog: https://ccmevidence.blog/ that will discuss specific methodological and analytical issues.

Welcome to the first episode of CRITKNOW!

CRITKNOW will focus on a variety of themes related to the practice of evidence-based critical care and is co-hosted by Bharath Kumar Tirupakuzhi Vijayaraghavan and Ramesh Venkataraman.

Bharath is a mid-career clinician–researcher with a primary focus on improving outcomes from critical illness in patients in low- and middle-income countries (LMICs). He is also deeply passionate about teaching evidence-based medicine and helping clinicians interpret and apply emerging evidence in patient care. You can learn more about his work here: https://www.researchgate.net/profile/Bharath-Kumar-Tirupakuzhi-Vijayaraghavan?ev=hdr_xprf

Ramesh is American Board–certified in Internal Medicine, Critical Care Medicine, and Neurocritical Care. He is also a senior researcher with a special interest in acute kidney injury and renal replacement therapies. A highly respected teacher, he has a unique ability to integrate emerging evidence into bedside clinical practice. You can learn more about his work here: https://icuconsultants.com/dr-ramesh-venkataraman/

Bharath and Ramesh are both Senior Consultants in the Department of Critical Care Medicine at Apollo Hospitals, Chennai and affiliated with Chennai Critical Care Consultants Private Limited, an academic critical care group practice (https://icuconsultants.com/). Bharath is also affiliated with the University of Edinburgh as a Clinical Research Fellow (https://inflammation-research.ed.ac.uk/research/research-groups/dr-bharath-kumar)

Views expressed are personal.

We are also complementing the content here with a blog that will discuss specific methodological and analytical issues. Here is the link to the blog on win ratios: https://ccmevidence.blog/2026/03/18/win-ra... and to the one on composite outcomes: https://ccmevidence.blog/2026/03/28/compos...

Takeaways

• Evolution of goal-directed resuscitation
• Understanding win ratio and composite outcomes

Chapters

• 00:00 Introduction to CRITKNOW Podcast
• 07:10 Andromeda 2 Shock Trial Overview
• 14:18 Composite Outcomes and Win Ratio
• 19:59 Secondary Outcomes and Results